Systematic production of inactivating and non-inactivating suppressor mutations at the relA locus that compensate the detrimental effects of complete spot loss and affect glycogen content in Escherichia coli.

Systematic production of inactivating and non-inactivating suppressor mutations at the relA locus that compensate the detrimental effects of complete spot loss and affect glycogen content in Escherichia coli.

In Escherichia coli, ppGpp is a major determinant of growth and glycogen accumulation. Levels of this signaling nucleotide are controlled by the balanced activities of the ppGpp RelA synthetase and the dual-function hydrolase/synthetase SpoT. Here we report the construction of spoT null (ΔspoT) muta...

Full description

Bibliographic Details
Main Authors:	Manuel Montero, Mehdi Rahimpour, Alejandro M Viale, Goizeder Almagro, Gustavo Eydallin, Ángel Sevilla, Manuel Cánovas, Cristina Bernal, Ana Belén Lozano, Francisco José Muñoz, Edurne Baroja-Fernández, Abdellatif Bahaji, Hirotada Mori, Francisco M Codoñer, Javier Pozueta-Romero
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2014-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC4154780?pdf=render

Similar Items

Comparative genomic and phylogenetic analyses of Gammaproteobacterial glg genes traced the origin of the Escherichia coli glycogen glgBXCAP operon to the last common ancestor of the sister orders Enterobacteriales and Pasteurellales.
by: Goizeder Almagro, et al.
Published: (2015-01-01)

Microbial Volatile-Induced Accumulation of Exceptionally High Levels of Starch in Arabidopsis Leaves Is a Process Involving NTRC and Starch Synthase Classes III and IV
by: Jun Li, et al.
Published: (2011-10-01)

Identification of genes responsible for RelA-dependent proliferation arrest in human mammary epithelial cells conditionally expressing RelA
by: Bose S. Kochupurakkal, et al.
Published: (2016-03-01)

NF-κB/Rel Transcription Factors in Pancreatic Cancer: Focusing on RelA, c-Rel, and RelB
by: Derya Kabacaoglu, et al.
Published: (2019-07-01)

Mechanism of glycogen synthase inactivation and interaction with glycogenin
by: Laura Marr, et al.
Published: (2022-06-01)

Enhanced Yield of Pepper Plants Promoted by Soil Application of Volatiles From Cell-Free Fungal Culture Filtrates Is Associated With Activation of the Beneficial Soil Microbiota
by: Edurne Baroja-Fernández, et al.
Published: (2021-10-01)

relA enhances the adherence of enteropathogenic Escherichia coli.
by: Beny Spira, et al.
Published: (2014-01-01)

Genetic and isotope ratio mass spectrometric evidence for the occurrence of starch degradation and cycling in illuminated Arabidopsis leaves.
by: Marouane Baslam, et al.
Published: (2017-01-01)

HPLC-MS/MS analyses show that the near-Starchless aps1 and pgm leaves accumulate wild type levels of ADPglucose: further evidence for the occurrence of important ADPglucose biosynthetic pathway(s) alternative to the pPGI-pPGM-AGP pathway.
by: Abdellatif Bahaji, et al.
Published: (2014-01-01)

RelA-Induced Interferon Response Negatively Regulates Proliferation.
by: Bose S Kochupurakkal, et al.
Published: (2015-01-01)

Proteostatic Regulation of MEP and Shikimate Pathways by Redox-Activated Photosynthesis Signaling in Plants Exposed to Small Fungal Volatiles
by: Kinia Ameztoy, et al.
Published: (2021-03-01)

Co-imaging of RelA and c-Rel reveals features of NF-κB signaling for ligand discrimination
by: Shah Md Toufiqur Rahman, et al.
Published: (2024-03-01)

IRF5:RelA interaction targets inflammatory genes in macrophages.
by: Saliba, D, et al.
Published: (2014)

Effects of Human RelA Transgene on Murine Macrophage Inflammatory Responses
by: Stamatia Papoutsopoulou, et al.
Published: (2022-03-01)

Ribosome•RelA structures reveal the mechanism of stringent response activation
by: Anna B Loveland, et al.
Published: (2016-07-01)

The role of relA and spoT in Yersinia pestis KIM5 pathogenicity.
by: Wei Sun, et al.
Published: (2009-08-01)

IRF5:RelA Interaction Targets Inflammatory Genes in Macrophages
by: David G. Saliba, et al.
Published: (2014-09-01)

Differential RelA- and RelB-dependent gene transcription in LTβR-stimulated mouse embryonic fibroblasts
by: Yilmaz Z Buket, et al.
Published: (2008-12-01)

NF-κB repression by PIAS3 mediated RelA SUMOylation.
by: Yuangang Liu, et al.
Published: (2012-01-01)

Escherichia coli RelA Regulation via Its C-Terminal Domain
by: Ilana Kaspy, et al.
Published: (2020-11-01)

Identification of a Selective RelA Inhibitor Based on DSE-FRET Screening Methods
by: Yoshitomo Shiroma, et al.
Published: (2020-11-01)

NirD curtails the stringent response by inhibiting RelA activity in Escherichia coli
by: Loïc Léger, et al.
Published: (2021-07-01)

Deletion of relA abrogates the capacity of Mycobacterium avium paratuberculosis to establish an infection in calves
by: Kun Taek ePark, et al.
Published: (2014-05-01)

Deubiquitinylase USP47 Promotes RelA Phosphorylation and Survival in Gastric Cancer Cells
by: Lara Naghavi, et al.
Published: (2018-05-01)

Mitochondrial Zea mays Brittle1-1 Is a Major Determinant of the Metabolic Fate of Incoming Sucrose and Mitochondrial Function in Developing Maize Endosperms
by: Abdellatif Bahaji, et al.
Published: (2019-03-01)

Plastidic phosphoglucose isomerase is an important determinant of starch accumulation in mesophyll cells, growth, photosynthetic capacity, and biosynthesis of plastidic cytokinins in Arabidopsis.
by: Abdellatif Bahaji, et al.
Published: (2015-01-01)

Correction: Plastidic phosphoglucose isomerase is an important determinant of starch accumulation in mesophyll cells, growth, photosynthetic capacity, and biosynthesis of plastidic cytokinins in Arabidopsis.
by: Abdellatif Bahaji, et al.
Published: (2015-01-01)

NF-κB RelA is a cell-intrinsic metabolic checkpoint restricting glycolysis
by: Liwen Li, et al.
Published: (2024-01-01)

LDP alleviates TKI-induced proteinuria through reversing the expression of RelA in renal tissues
by: Zhou Fu, et al.
Published: (2023-01-01)

NFκB (RelA) mediates transactivation of hnRNPD in oral cancer cells
by: Vikas Kumar, et al.
Published: (2022-04-01)

The NF-κB RelA Transcription Factor Is Critical for Regulatory T Cell Activation and Stability
by: Emilie Ronin, et al.
Published: (2019-10-01)

The RelA hydrolase domain acts as a molecular switch for (p)ppGpp synthesis
by: Anurag Kumar Sinha, et al.
Published: (2021-03-01)

PTPIP51—A New RelA-tionship with the NFκB Signaling Pathway
by: Alexander Brobeil, et al.
Published: (2015-04-01)

Prolyl hydroxylase 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses
by: Sadiku, P, et al.
Published: (2017)

Cell-free microbial culture filtrates as candidate biostimulants to enhance plant growth and yield and activate soil- and plant-associated beneficial microbiota
by: Rafael Jorge León Morcillo, et al.
Published: (2022-12-01)

RelA and mitogen-activated protein kinase kinase kinases potently enhance lentiviral vector production
by: Shoji Yamaoka
Published: (2024-03-01)

Differential expression of NF-κB heterodimer RelA/p50 in human urothelial carcinoma
by: Sankari Durairajan, et al.
Published: (2018-09-01)

Influence of the RelA Activity on E. coli Metabolism by Metabolite Profiling of Glucose-Limited Chemostat Cultures
by: Sónia Carneiro, et al.
Published: (2012-10-01)

Expression of tumor necrosis factor-α and nuclear factor-kappaB/RelA and the pathogenesis of psoriasis
by: Nikhil Moorchung, et al.
Published: (2014-01-01)

Identification of a RelA/SpoT Homolog and Its Possible Role in the Accumulation of Astaxanthin in Haematococcus pluvialis
by: Hui Jin, et al.
Published: (2022-02-01)