Intranasal delivery of mitochondria for treatment of Parkinson’s Disease model rats lesioned with 6-hydroxydopamine

Intranasal delivery of mitochondria for treatment of Parkinson’s Disease model rats lesioned with 6-hydroxydopamine

Abstract The feasibility of delivering mitochondria intranasally so as to bypass the blood–brain barrier in treating Parkinson's disease (PD), was evaluated in unilaterally 6-OHDA-lesioned rats. Intranasal infusion of allogeneic mitochondria conjugated with Pep-1 (P-Mito) or unconjugated (Mito)...

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Bibliographic Details
Main Authors:	Jui-Chih Chang, Yi-Chun Chao, Huei-Shin Chang, Yu-Ling Wu, Hui-Ju Chang, Yong-Shiou Lin, Wen-Ling Cheng, Ta-Tsung Lin, Chin-San Liu
Format:	Article
Language:	English
Published:	Nature Portfolio 2021-05-01
Series:	Scientific Reports
Online Access:	https://doi.org/10.1038/s41598-021-90094-w

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