Systemic Lupus Erythematous and Obstructive Sleep Apnea: A Possible Association
Marked fatigue is common in patients with systemic lupus erythematosus (SLE). This study aimed to assess the association of sleep disorders, including obstructive sleep apnea (OSA), with SLE. Forty-two consecutive patients with SLE and 20 healthy controls were recruited and underwent a one-night amb...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/13/3/697 |
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| author | Roni Meidan Ofir Elalouf Riva Tauman Victoria Furer Ari Polachek Jonathan Wollman Tali Eviatar Michael Zisapel David Levartovsky Estelle Seyman Ori Elkayam Daphna Paran |
| author_facet | Roni Meidan Ofir Elalouf Riva Tauman Victoria Furer Ari Polachek Jonathan Wollman Tali Eviatar Michael Zisapel David Levartovsky Estelle Seyman Ori Elkayam Daphna Paran |
| author_sort | Roni Meidan |
| collection | DOAJ |
| description | Marked fatigue is common in patients with systemic lupus erythematosus (SLE). This study aimed to assess the association of sleep disorders, including obstructive sleep apnea (OSA), with SLE. Forty-two consecutive patients with SLE and 20 healthy controls were recruited and underwent a one-night ambulatory sleep examination. They completed questionnaires, including the Pittsburgh Sleep Quality Index (PSQI) and Functional Assessment of Chronic Illness Therapy (FACIT). SLE disease activity and damage were assessed by the SLE Disease Activity Index 2000 (SLEDAI-2K) and the Systemic Lupus International Collaborating Clinics/American College of Rheumatology (SLICC/ACR) damage index (SDI). A significantly increased apnea/hypopnea index was noted in the SLE group compared to healthy controls (<i>p</i> = 0.004). SLE patients had higher rates of moderate-to-severe OSA (<i>p</i> = 0.04), PSQI (<i>p</i> = 0.001), and FACIT scores (<i>p</i> = 0.0008). Multivariate analysis revealed that the SDI was associated with OSA (<i>p</i> = 0.03). There was a positive association between SLEDAI-2K and moderate-to-severe OSA (<i>p</i> = 0.03). Patients with SLE had an increased prevalence of OSA and poorer quality of sleep compared to healthy controls. Our findings suggest that active disease and accumulated damage may be associated with OSA. These findings highlight the importance of identifying the presence of OSA in patients with SLE. |
| first_indexed | 2024-03-11T06:17:21Z |
| format | Article |
| id | doaj.art-8244206fb3534c3a92a1250a16e19b25 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-11T06:17:21Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-8244206fb3534c3a92a1250a16e19b252023-11-17T12:11:07ZengMDPI AGLife2075-17292023-03-0113369710.3390/life13030697Systemic Lupus Erythematous and Obstructive Sleep Apnea: A Possible AssociationRoni Meidan0Ofir Elalouf1Riva Tauman2Victoria Furer3Ari Polachek4Jonathan Wollman5Tali Eviatar6Michael Zisapel7David Levartovsky8Estelle Seyman9Ori Elkayam10Daphna Paran11Department of Rheumatology, Tel Aviv Sourasky Medical Center, Tel Aviv 6423906, IsraelDepartment of Rheumatology, Tel Aviv Sourasky Medical Center, Tel Aviv 6423906, IsraelSackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, IsraelDepartment of Rheumatology, Tel Aviv Sourasky Medical Center, Tel Aviv 6423906, IsraelDepartment of Rheumatology, Tel Aviv Sourasky Medical Center, Tel Aviv 6423906, IsraelDepartment of Rheumatology, Tel Aviv Sourasky Medical Center, Tel Aviv 6423906, IsraelDepartment of Rheumatology, Tel Aviv Sourasky Medical Center, Tel Aviv 6423906, IsraelDepartment of Rheumatology, Tel Aviv Sourasky Medical Center, Tel Aviv 6423906, IsraelDepartment of Rheumatology, Tel Aviv Sourasky Medical Center, Tel Aviv 6423906, IsraelSackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, IsraelDepartment of Rheumatology, Tel Aviv Sourasky Medical Center, Tel Aviv 6423906, IsraelDepartment of Rheumatology, Tel Aviv Sourasky Medical Center, Tel Aviv 6423906, IsraelMarked fatigue is common in patients with systemic lupus erythematosus (SLE). This study aimed to assess the association of sleep disorders, including obstructive sleep apnea (OSA), with SLE. Forty-two consecutive patients with SLE and 20 healthy controls were recruited and underwent a one-night ambulatory sleep examination. They completed questionnaires, including the Pittsburgh Sleep Quality Index (PSQI) and Functional Assessment of Chronic Illness Therapy (FACIT). SLE disease activity and damage were assessed by the SLE Disease Activity Index 2000 (SLEDAI-2K) and the Systemic Lupus International Collaborating Clinics/American College of Rheumatology (SLICC/ACR) damage index (SDI). A significantly increased apnea/hypopnea index was noted in the SLE group compared to healthy controls (<i>p</i> = 0.004). SLE patients had higher rates of moderate-to-severe OSA (<i>p</i> = 0.04), PSQI (<i>p</i> = 0.001), and FACIT scores (<i>p</i> = 0.0008). Multivariate analysis revealed that the SDI was associated with OSA (<i>p</i> = 0.03). There was a positive association between SLEDAI-2K and moderate-to-severe OSA (<i>p</i> = 0.03). Patients with SLE had an increased prevalence of OSA and poorer quality of sleep compared to healthy controls. Our findings suggest that active disease and accumulated damage may be associated with OSA. These findings highlight the importance of identifying the presence of OSA in patients with SLE.https://www.mdpi.com/2075-1729/13/3/697systemic lupus erythematosusobstructive sleep apneasleep-disordered breathingWatchPAT |
| spellingShingle | Roni Meidan Ofir Elalouf Riva Tauman Victoria Furer Ari Polachek Jonathan Wollman Tali Eviatar Michael Zisapel David Levartovsky Estelle Seyman Ori Elkayam Daphna Paran Systemic Lupus Erythematous and Obstructive Sleep Apnea: A Possible Association Life systemic lupus erythematosus obstructive sleep apnea sleep-disordered breathing WatchPAT |
| title | Systemic Lupus Erythematous and Obstructive Sleep Apnea: A Possible Association |
| title_full | Systemic Lupus Erythematous and Obstructive Sleep Apnea: A Possible Association |
| title_fullStr | Systemic Lupus Erythematous and Obstructive Sleep Apnea: A Possible Association |
| title_full_unstemmed | Systemic Lupus Erythematous and Obstructive Sleep Apnea: A Possible Association |
| title_short | Systemic Lupus Erythematous and Obstructive Sleep Apnea: A Possible Association |
| title_sort | systemic lupus erythematous and obstructive sleep apnea a possible association |
| topic | systemic lupus erythematosus obstructive sleep apnea sleep-disordered breathing WatchPAT |
| url | https://www.mdpi.com/2075-1729/13/3/697 |
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