Plazomicin against Multidrug-Resistant Bacteria: A Scoping Review
Plazomicin is a next-generation semisynthetic aminoglycoside antibiotic that can be used to treat infections by multi-resistant bacteria. It is effective against many bacteria-producing carbapenemases or other specific hydrolases. This scoping review aims to define the role acquired by plazomicin fr...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/12/12/1949 |
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| author | Aniello Alfieri Sveva Di Franco Valerio Donatiello Vincenzo Maffei Ciro Fittipaldi Marco Fiore Francesco Coppolino Pasquale Sansone Maria Caterina Pace Maria Beatrice Passavanti |
| author_facet | Aniello Alfieri Sveva Di Franco Valerio Donatiello Vincenzo Maffei Ciro Fittipaldi Marco Fiore Francesco Coppolino Pasquale Sansone Maria Caterina Pace Maria Beatrice Passavanti |
| author_sort | Aniello Alfieri |
| collection | DOAJ |
| description | Plazomicin is a next-generation semisynthetic aminoglycoside antibiotic that can be used to treat infections by multi-resistant bacteria. It is effective against many bacteria-producing carbapenemases or other specific hydrolases. This scoping review aims to define the role acquired by plazomicin from its approval by the FDA (US Food and Drug Administration) in 2018 to the present day. Furthermore, we aim to provide a base for a future meta-analysis. This project was conducted following the recommendations presented in the PRISMA extension for scoping reviews and the JBI Manual for Evidence Synthesis. Among 901 potentially engaging citations, 345 duplicates were removed, and only 81 articles were selected for the analysis. According to the data analysis, plazomicin has been used to treat urinary tract infections, bloodstream infections, and ventilation-associated pneumonia. The pathogens killed included multi-resistant <i>E. coli</i>, <i>K. pneumoniae</i>, <i>A. baumannii</i>, <i>P. aeruginosa</i>, and <i>S. aureus</i>. Plazomicin can be a manageable, valid non-beta-lactam alternative for treating multi-resistant bacteria infections. |
| first_indexed | 2024-03-09T16:12:06Z |
| format | Article |
| id | doaj.art-824a59dcf2f94af0b1c94f475b50cc2f |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-09T16:12:06Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-824a59dcf2f94af0b1c94f475b50cc2f2023-11-24T16:10:57ZengMDPI AGLife2075-17292022-11-011212194910.3390/life12121949Plazomicin against Multidrug-Resistant Bacteria: A Scoping ReviewAniello Alfieri0Sveva Di Franco1Valerio Donatiello2Vincenzo Maffei3Ciro Fittipaldi4Marco Fiore5Francesco Coppolino6Pasquale Sansone7Maria Caterina Pace8Maria Beatrice Passavanti9Department of Elective Surgery, Postoperative Intensive Care Unit and Hyperbaric Oxygen Therapy, A.O.R.N. Antonio Cardarelli, Viale Antonio Cardarelli 9, 80131 Naples, ItalyDepartment of Women, Child and General and Specialized Surgery, University of Campania Luigi Vanvitelli, Piazza Miraglia 2, 80138 Naples, ItalyDepartment of Elective Surgery, Postoperative Intensive Care Unit and Hyperbaric Oxygen Therapy, A.O.R.N. Antonio Cardarelli, Viale Antonio Cardarelli 9, 80131 Naples, ItalyDepartment of Elective Surgery, Postoperative Intensive Care Unit and Hyperbaric Oxygen Therapy, A.O.R.N. Antonio Cardarelli, Viale Antonio Cardarelli 9, 80131 Naples, ItalyUnit of Critical Care, Hospital “Ospedale Pellegrini”, Via Portamedina alla Pignasecca 41, 80134 Naples, ItalyDepartment of Women, Child and General and Specialized Surgery, University of Campania Luigi Vanvitelli, Piazza Miraglia 2, 80138 Naples, ItalyDepartment of Women, Child and General and Specialized Surgery, University of Campania Luigi Vanvitelli, Piazza Miraglia 2, 80138 Naples, ItalyDepartment of Women, Child and General and Specialized Surgery, University of Campania Luigi Vanvitelli, Piazza Miraglia 2, 80138 Naples, ItalyDepartment of Women, Child and General and Specialized Surgery, University of Campania Luigi Vanvitelli, Piazza Miraglia 2, 80138 Naples, ItalyDepartment of Women, Child and General and Specialized Surgery, University of Campania Luigi Vanvitelli, Piazza Miraglia 2, 80138 Naples, ItalyPlazomicin is a next-generation semisynthetic aminoglycoside antibiotic that can be used to treat infections by multi-resistant bacteria. It is effective against many bacteria-producing carbapenemases or other specific hydrolases. This scoping review aims to define the role acquired by plazomicin from its approval by the FDA (US Food and Drug Administration) in 2018 to the present day. Furthermore, we aim to provide a base for a future meta-analysis. This project was conducted following the recommendations presented in the PRISMA extension for scoping reviews and the JBI Manual for Evidence Synthesis. Among 901 potentially engaging citations, 345 duplicates were removed, and only 81 articles were selected for the analysis. According to the data analysis, plazomicin has been used to treat urinary tract infections, bloodstream infections, and ventilation-associated pneumonia. The pathogens killed included multi-resistant <i>E. coli</i>, <i>K. pneumoniae</i>, <i>A. baumannii</i>, <i>P. aeruginosa</i>, and <i>S. aureus</i>. Plazomicin can be a manageable, valid non-beta-lactam alternative for treating multi-resistant bacteria infections.https://www.mdpi.com/2075-1729/12/12/1949antimicrobial resistancebloodstream infectionsmulti-resistant <i>Enterobacterales</i>pyelonephritisplazomicinscoping review |
| spellingShingle | Aniello Alfieri Sveva Di Franco Valerio Donatiello Vincenzo Maffei Ciro Fittipaldi Marco Fiore Francesco Coppolino Pasquale Sansone Maria Caterina Pace Maria Beatrice Passavanti Plazomicin against Multidrug-Resistant Bacteria: A Scoping Review Life antimicrobial resistance bloodstream infections multi-resistant <i>Enterobacterales</i> pyelonephritis plazomicin scoping review |
| title | Plazomicin against Multidrug-Resistant Bacteria: A Scoping Review |
| title_full | Plazomicin against Multidrug-Resistant Bacteria: A Scoping Review |
| title_fullStr | Plazomicin against Multidrug-Resistant Bacteria: A Scoping Review |
| title_full_unstemmed | Plazomicin against Multidrug-Resistant Bacteria: A Scoping Review |
| title_short | Plazomicin against Multidrug-Resistant Bacteria: A Scoping Review |
| title_sort | plazomicin against multidrug resistant bacteria a scoping review |
| topic | antimicrobial resistance bloodstream infections multi-resistant <i>Enterobacterales</i> pyelonephritis plazomicin scoping review |
| url | https://www.mdpi.com/2075-1729/12/12/1949 |
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