| Summary: | Background. Hydrogen sulfide (H2S) in high concentrations is a toxic pollutant.
Due to the risk of its impact on the organism of people living in the areas of its production as part of natural gas, it is necessary to expand the pathogenetically substantiated profile of
diagnosing the consequences of its impact. The purpose of the study is to evaluate the effect
of hydrogen sulfide (its sulfide ions H–HS) on the processes of senescence and peroxidation
in the kidneys of old rats. Materials and methods: With the help of an H2S (Na2S) donor,
intraperitoneal toxic effects of sulfide ions were simulated in 18-20-months-old rats.
Sections and homogenates of renal tissue were examined for the presence of lipofuscincontaining
senescent cells (SC), the level of interleukin-6, catalase, and oxidative modification
of proteins in the presence of metals of variable valence. Results. SCs located diffusely
between the renal bodies of the juxtamedullary and subcapsular nephrons of the kidney
were identified. An increase in the level of interleukin-6, catalase and aldehyde dinitrophenylhydrazones
was recorded. Conclusions. The applied experimental approach using
Na2S as a donor promotes the formation of a senescent morphotype in a functioning kidney
in old rats. The functional features of the kidneys determine the predominant toxic load on
the renal corpuscles of the nephrons. Accumulation of lipofuscin by cells and an increase in
the level of pro-inflammatory interleukin-6 are promoted by active processes of prooxidation
of the protein components of cells. Distribution of the secretion of SA contributes
to increased metabolic inconsistency and forms a vicious circle that increases the activity of
the antioxidant catalase.
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