Treatment of Psoriasis Vulgaris with Calcipotriol Betamethasone Dipropionate Combination Followed by Calcipotriol and Assessment of the Adjuvant Basic Use of Urea-Based Emollients
A new combination product containing betamethasone dipropionate and calcipotriol (Dovobet® ointment) has been proven very effective and well tolerated in patients with psoriasis vulgaris. Emollients are adjunctive modalities commonly used in psoriasis; however, their actual role in combination with...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2005-01-01
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| Series: | European Journal of Inflammation |
| Online Access: | https://doi.org/10.1177/1721727X0500300108 |
| _version_ | 1818872601695485952 |
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| author | G.A. Vena N. Cassano C.P. Agnusdei M. Bellini S. Calabretta S. Centofanti G. Cervadoro C. Coviello S. Curia S. Dattola C. De Caro L. Del Brocco L. Donato L. Favero A. Ferrari R. Gianfaldoni G. Liguori F. Loconsole R. Lopreiato G. Malara S.D. Massimino A. Nannipieri M. Pettinato D. Postiglione C. Postorino M.E. Pronesti' E.O. Provenzano A. Puglisi Guerra F. Ricciuti G. Ruggiero A. Scudero S. Spitaleri F. Trinca Armati G. Valenti R. Vernaci F. Verrina G.F. Zagni F. Zappala' |
| author_facet | G.A. Vena N. Cassano C.P. Agnusdei M. Bellini S. Calabretta S. Centofanti G. Cervadoro C. Coviello S. Curia S. Dattola C. De Caro L. Del Brocco L. Donato L. Favero A. Ferrari R. Gianfaldoni G. Liguori F. Loconsole R. Lopreiato G. Malara S.D. Massimino A. Nannipieri M. Pettinato D. Postiglione C. Postorino M.E. Pronesti' E.O. Provenzano A. Puglisi Guerra F. Ricciuti G. Ruggiero A. Scudero S. Spitaleri F. Trinca Armati G. Valenti R. Vernaci F. Verrina G.F. Zagni F. Zappala' |
| author_sort | G.A. Vena |
| collection | DOAJ |
| description | A new combination product containing betamethasone dipropionate and calcipotriol (Dovobet® ointment) has been proven very effective and well tolerated in patients with psoriasis vulgaris. Emollients are adjunctive modalities commonly used in psoriasis; however, their actual role in combination with topical drugs as well as well as their compatibility with these drugs have not been well elucidated. In 313 adult patients with psoriasis vulgaris, we studied the efficacy and tolerability of treatment with Dovobet® ointment combined with urea-based emollients (Excipial U®) for 4 weeks, followed by treatment with calcipotriol (Daivonex®) either alone (group A) or combined with urea-containing emollients (Excipial U®, group B) for 8 weeks. Clinical evaluations were performed at baseline, at 4 and 12 weeks, assessing the clinical score for erythema, scaling, infiltration and pruritus, graded on the basis of a 5-point scale. After the initial 4-week treatment, a significant improvement of all clinical parameters was observed (p<0.05). Overall, clinical results improved further during the maintenance treatment phase; significant changes (p<0.05) were observed in each group. Most patients considered treatment efficacy positively at both 4 weeks and 12 weeks. Interestingly, at the end of the study, a greater percentage of patients in group B than in group A judged the efficacy as excellent. Treatment was very well tolerated. Only two patients complained of mild and transient burning sensation during the first days of treatment. The results of this study confirm the great efficacy and tolerability of sequential treatment with Dovobet®, and Daivonex® in psoriasis vulgaris and show the enhanced acceptability of this treatment associated with urea-based emollients. |
| first_indexed | 2024-12-19T12:41:25Z |
| format | Article |
| id | doaj.art-824f073f5e4d41b6a7881e7d2c87ed76 |
| institution | Directory Open Access Journal |
| issn | 1721-727X |
| language | English |
| last_indexed | 2024-12-19T12:41:25Z |
| publishDate | 2005-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | European Journal of Inflammation |
| spelling | doaj.art-824f073f5e4d41b6a7881e7d2c87ed762022-12-21T20:20:58ZengSAGE PublishingEuropean Journal of Inflammation1721-727X2005-01-01310.1177/1721727X0500300108Treatment of Psoriasis Vulgaris with Calcipotriol Betamethasone Dipropionate Combination Followed by Calcipotriol and Assessment of the Adjuvant Basic Use of Urea-Based EmollientsG.A. Vena0N. Cassano1C.P. Agnusdei2M. Bellini3S. Calabretta4S. Centofanti5G. Cervadoro6C. Coviello7S. Curia8S. Dattola9C. De Caro10L. Del Brocco11L. Donato12L. Favero13A. Ferrari14R. Gianfaldoni15G. Liguori16F. Loconsole17R. Lopreiato18G. Malara19S.D. Massimino20A. Nannipieri21M. Pettinato22D. Postiglione23C. Postorino24M.E. Pronesti'25E.O. Provenzano26A. Puglisi Guerra27F. Ricciuti28G. Ruggiero29A. Scudero30S. Spitaleri31F. Trinca Armati32G. Valenti33R. Vernaci34F. Verrina35G.F. Zagni36F. Zappala'37 2nd Unit of Dermatology - MIDIM Department, University of Bari, Italy Istituto Dermopatico dell'Immacolata, Rome, Italy Italian Group for the Study of Emollients in Psoriasis Italian Group for the Study of Emollients in Psoriasis Italian Group for the Study of Emollients in Psoriasis Italian Group for the Study of Emollients in Psoriasis Italian Group for the Study of Emollients in Psoriasis 2nd Unit of Dermatology - MIDIM Department, University of Bari, Italy Italian Group for the Study of Emollients in Psoriasis Italian Group for the Study of Emollients in Psoriasis Italian Group for the Study of Emollients in Psoriasis Italian Group for the Study of Emollients in Psoriasis Italian Group for the Study of Emollients in Psoriasis Italian Group for the Study of Emollients in Psoriasis Italian Group for the Study of Emollients in Psoriasis Italian Group for the Study of Emollients in Psoriasis Italian Group for the Study of Emollients in Psoriasis 2nd Unit of Dermatology - MIDIM Department, University of Bari, Italy Italian Group for the Study of Emollients in Psoriasis Italian Group for the Study of Emollients in Psoriasis Italian Group for the Study of Emollients in Psoriasis Italian Group for the Study of Emollients in Psoriasis Italian Group for the Study of Emollients in Psoriasis Italian Group for the Study of Emollients in Psoriasis Italian Group for the Study of Emollients in Psoriasis Italian Group for the Study of Emollients in Psoriasis Italian Group for the Study of Emollients in Psoriasis Italian Group for the Study of Emollients in Psoriasis Italian Group for the Study of Emollients in Psoriasis Italian Group for the Study of Emollients in Psoriasis Italian Group for the Study of Emollients in Psoriasis Italian Group for the Study of Emollients in Psoriasis Italian Group for the Study of Emollients in Psoriasis Italian Group for the Study of Emollients in Psoriasis Italian Group for the Study of Emollients in Psoriasis Italian Group for the Study of Emollients in Psoriasis Italian Group for the Study of Emollients in Psoriasis Italian Group for the Study of Emollients in PsoriasisA new combination product containing betamethasone dipropionate and calcipotriol (Dovobet® ointment) has been proven very effective and well tolerated in patients with psoriasis vulgaris. Emollients are adjunctive modalities commonly used in psoriasis; however, their actual role in combination with topical drugs as well as well as their compatibility with these drugs have not been well elucidated. In 313 adult patients with psoriasis vulgaris, we studied the efficacy and tolerability of treatment with Dovobet® ointment combined with urea-based emollients (Excipial U®) for 4 weeks, followed by treatment with calcipotriol (Daivonex®) either alone (group A) or combined with urea-containing emollients (Excipial U®, group B) for 8 weeks. Clinical evaluations were performed at baseline, at 4 and 12 weeks, assessing the clinical score for erythema, scaling, infiltration and pruritus, graded on the basis of a 5-point scale. After the initial 4-week treatment, a significant improvement of all clinical parameters was observed (p<0.05). Overall, clinical results improved further during the maintenance treatment phase; significant changes (p<0.05) were observed in each group. Most patients considered treatment efficacy positively at both 4 weeks and 12 weeks. Interestingly, at the end of the study, a greater percentage of patients in group B than in group A judged the efficacy as excellent. Treatment was very well tolerated. Only two patients complained of mild and transient burning sensation during the first days of treatment. The results of this study confirm the great efficacy and tolerability of sequential treatment with Dovobet®, and Daivonex® in psoriasis vulgaris and show the enhanced acceptability of this treatment associated with urea-based emollients.https://doi.org/10.1177/1721727X0500300108 |
| spellingShingle | G.A. Vena N. Cassano C.P. Agnusdei M. Bellini S. Calabretta S. Centofanti G. Cervadoro C. Coviello S. Curia S. Dattola C. De Caro L. Del Brocco L. Donato L. Favero A. Ferrari R. Gianfaldoni G. Liguori F. Loconsole R. Lopreiato G. Malara S.D. Massimino A. Nannipieri M. Pettinato D. Postiglione C. Postorino M.E. Pronesti' E.O. Provenzano A. Puglisi Guerra F. Ricciuti G. Ruggiero A. Scudero S. Spitaleri F. Trinca Armati G. Valenti R. Vernaci F. Verrina G.F. Zagni F. Zappala' Treatment of Psoriasis Vulgaris with Calcipotriol Betamethasone Dipropionate Combination Followed by Calcipotriol and Assessment of the Adjuvant Basic Use of Urea-Based Emollients European Journal of Inflammation |
| title | Treatment of Psoriasis Vulgaris with Calcipotriol Betamethasone Dipropionate Combination Followed by Calcipotriol and Assessment of the Adjuvant Basic Use of Urea-Based Emollients |
| title_full | Treatment of Psoriasis Vulgaris with Calcipotriol Betamethasone Dipropionate Combination Followed by Calcipotriol and Assessment of the Adjuvant Basic Use of Urea-Based Emollients |
| title_fullStr | Treatment of Psoriasis Vulgaris with Calcipotriol Betamethasone Dipropionate Combination Followed by Calcipotriol and Assessment of the Adjuvant Basic Use of Urea-Based Emollients |
| title_full_unstemmed | Treatment of Psoriasis Vulgaris with Calcipotriol Betamethasone Dipropionate Combination Followed by Calcipotriol and Assessment of the Adjuvant Basic Use of Urea-Based Emollients |
| title_short | Treatment of Psoriasis Vulgaris with Calcipotriol Betamethasone Dipropionate Combination Followed by Calcipotriol and Assessment of the Adjuvant Basic Use of Urea-Based Emollients |
| title_sort | treatment of psoriasis vulgaris with calcipotriol betamethasone dipropionate combination followed by calcipotriol and assessment of the adjuvant basic use of urea based emollients |
| url | https://doi.org/10.1177/1721727X0500300108 |
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