Role of pyroptosis in COVID-19
<b>Aim:</b> In this study, we aimed to investigate the relationship between gasdermin-D, caspase-1, IL-1β and NLRP3, biomarkers that play an important role in COVID-19, and pyroptosis.<br /> <b>Material and Methods:</b> This study was carried out with 58 participants, 2...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
National Scientific Medical Center
2023-04-01
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| Series: | Ķazaķstannyṇ Klinikalyķ Medicinasy |
| Subjects: | |
| Online Access: | https://www.clinmedkaz.org/download/role-of-pyroptosis-in-covid-19-13142.pdf |
| Summary: | <b>Aim:</b> In this study, we aimed to investigate the relationship between gasdermin-D, caspase-1, IL-1β and NLRP3, biomarkers that play an important role in COVID-19, and pyroptosis.<br />
<b>Material and Methods:</b> This study was carried out with 58 participants, 28 (48.28%) of whom were diagnosis with COVID-19, and 30 (51.72%) of whom were healthy volunteers (control group).<br />
<b>Results:</b> There were no statistically significant differences between the gasdermin-D, caspase-1, IL-1β, and NLRP3 levels as a result of all statistical comparisons performed. However, IL-1β values both during the discharge period and during the hospitalization period were considerably higher than those of the control group. At the discharge period, IL-1β values of the patients with severe COVID-19 category had higher than moderate patients, and the patients with moderate than the patients with mild patients.<br />
<b>Conclusion</b>: It was observed that IL-1β, which is one of the cytokines released as a result of cell death in the pyroptosis mechanism, was higher in the COVID-19 patients in both the hospitalization and discharge periods compared to the control group. Although not statistically significant these results could support the relationship between pyroptosis and COVID-19. |
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| ISSN: | 1812-2892 2313-1519 |