Role of pyroptosis in COVID-19
<b>Aim:</b> In this study, we aimed to investigate the relationship between gasdermin-D, caspase-1, IL-1β and NLRP3, biomarkers that play an important role in COVID-19, and pyroptosis.<br /> <b>Material and Methods:</b> This study was carried out with 58 participants, 2...
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| Format: | Article |
| Language: | English |
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National Scientific Medical Center
2023-04-01
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| Series: | Ķazaķstannyṇ Klinikalyķ Medicinasy |
| Subjects: | |
| Online Access: | https://www.clinmedkaz.org/download/role-of-pyroptosis-in-covid-19-13142.pdf |
| _version_ | 1797842450810667008 |
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| author | Mehmet Çelik Mehmet Reşat Ceylan Mahmut Alp Karahan İsmail Koyuncu Nevin Güler Dinçer Sevil Alkan |
| author_facet | Mehmet Çelik Mehmet Reşat Ceylan Mahmut Alp Karahan İsmail Koyuncu Nevin Güler Dinçer Sevil Alkan |
| author_sort | Mehmet Çelik |
| collection | DOAJ |
| description | <b>Aim:</b> In this study, we aimed to investigate the relationship between gasdermin-D, caspase-1, IL-1β and NLRP3, biomarkers that play an important role in COVID-19, and pyroptosis.<br />
<b>Material and Methods:</b> This study was carried out with 58 participants, 28 (48.28%) of whom were diagnosis with COVID-19, and 30 (51.72%) of whom were healthy volunteers (control group).<br />
<b>Results:</b> There were no statistically significant differences between the gasdermin-D, caspase-1, IL-1β, and NLRP3 levels as a result of all statistical comparisons performed. However, IL-1β values both during the discharge period and during the hospitalization period were considerably higher than those of the control group. At the discharge period, IL-1β values of the patients with severe COVID-19 category had higher than moderate patients, and the patients with moderate than the patients with mild patients.<br />
<b>Conclusion</b>: It was observed that IL-1β, which is one of the cytokines released as a result of cell death in the pyroptosis mechanism, was higher in the COVID-19 patients in both the hospitalization and discharge periods compared to the control group. Although not statistically significant these results could support the relationship between pyroptosis and COVID-19. |
| first_indexed | 2024-04-09T16:49:09Z |
| format | Article |
| id | doaj.art-82501ab6226a4e6a80d395d7a8316637 |
| institution | Directory Open Access Journal |
| issn | 1812-2892 2313-1519 |
| language | English |
| last_indexed | 2024-04-09T16:49:09Z |
| publishDate | 2023-04-01 |
| publisher | National Scientific Medical Center |
| record_format | Article |
| series | Ķazaķstannyṇ Klinikalyķ Medicinasy |
| spelling | doaj.art-82501ab6226a4e6a80d395d7a83166372023-04-22T05:12:21ZengNational Scientific Medical CenterĶazaķstannyṇ Klinikalyķ Medicinasy1812-28922313-15192023-04-01202394510.23950/jcmk/13142Role of pyroptosis in COVID-19Mehmet Çelik0Mehmet Reşat Ceylan1Mahmut Alp Karahan2İsmail Koyuncu3Nevin Güler Dinçer4Sevil Alkan5Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, University of Harran, Şanlıurfa, TurkeyDepartment of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, University of Harran, Şanlıurfa, TurkeyDepartment of Anesthesiology, Faculty of Medicine, University of Harran, Şanlıurfa, TurkeyDepartment of Medical Biochemistry, Faculty of Medicine, University of Harran, Şanlıurfa, TurkeyDepartment of Statistics, Faculty of Science, University of Muğla Sıtkı Koçman, Muğla, TurkeyDepartment of Infectious Diseases, Faculty of Medicine, Canakkale Onsekiz Mart University, Canakkale, Turkey<b>Aim:</b> In this study, we aimed to investigate the relationship between gasdermin-D, caspase-1, IL-1β and NLRP3, biomarkers that play an important role in COVID-19, and pyroptosis.<br /> <b>Material and Methods:</b> This study was carried out with 58 participants, 28 (48.28%) of whom were diagnosis with COVID-19, and 30 (51.72%) of whom were healthy volunteers (control group).<br /> <b>Results:</b> There were no statistically significant differences between the gasdermin-D, caspase-1, IL-1β, and NLRP3 levels as a result of all statistical comparisons performed. However, IL-1β values both during the discharge period and during the hospitalization period were considerably higher than those of the control group. At the discharge period, IL-1β values of the patients with severe COVID-19 category had higher than moderate patients, and the patients with moderate than the patients with mild patients.<br /> <b>Conclusion</b>: It was observed that IL-1β, which is one of the cytokines released as a result of cell death in the pyroptosis mechanism, was higher in the COVID-19 patients in both the hospitalization and discharge periods compared to the control group. Although not statistically significant these results could support the relationship between pyroptosis and COVID-19.https://www.clinmedkaz.org/download/role-of-pyroptosis-in-covid-19-13142.pdfCOVID-19; Interleukin-1β; Pyroptosis |
| spellingShingle | Mehmet Çelik Mehmet Reşat Ceylan Mahmut Alp Karahan İsmail Koyuncu Nevin Güler Dinçer Sevil Alkan Role of pyroptosis in COVID-19 Ķazaķstannyṇ Klinikalyķ Medicinasy COVID-19; Interleukin-1β; Pyroptosis |
| title | Role of pyroptosis in COVID-19 |
| title_full | Role of pyroptosis in COVID-19 |
| title_fullStr | Role of pyroptosis in COVID-19 |
| title_full_unstemmed | Role of pyroptosis in COVID-19 |
| title_short | Role of pyroptosis in COVID-19 |
| title_sort | role of pyroptosis in covid 19 |
| topic | COVID-19; Interleukin-1β; Pyroptosis |
| url | https://www.clinmedkaz.org/download/role-of-pyroptosis-in-covid-19-13142.pdf |
| work_keys_str_mv | AT mehmetcelik roleofpyroptosisincovid19 AT mehmetresatceylan roleofpyroptosisincovid19 AT mahmutalpkarahan roleofpyroptosisincovid19 AT ismailkoyuncu roleofpyroptosisincovid19 AT nevingulerdincer roleofpyroptosisincovid19 AT sevilalkan roleofpyroptosisincovid19 |