| Summary: | This article aims to provide theoretical predictions for the thermal reactions of human tissues during tumor thermotherapy when exposed to laser irradiation and an external heat source. For the construction of a theoretical study of bioheat transfer, the selection of a suitable thermal model capable of accurately predicting the required thermal responses is essential. The effect of heat production by heat treatment on a spherical multilayer tumor tissue is evaluated using this approach. Analytical solution for the non-homogenous differential equations is derived in the Laplace domain. The study examines the impact of thermal relaxation time on tissue temperature and the subsequent thermal damage. The numerical findings of thermal damage and temperatures are depicted in a graphical representation. This model explains laser treatment, physical events, metabolic support, and blood perfusion. The numerical outcomes of the recommended model are validated by comparing them to the literatures.
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