Effects of Hyperbaric Oxygen Therapy in Children with Severe Atopic Dermatitis
In the course of atopic dermatitis (AD), the overactivity of the immune system, associated with predominant Th2 lymphocyte responses, is observed, which leads to an increased inflammatory reaction. Cases of a severe course of atopic dermatitis lead to the search for new therapeutic options. The aim...
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MDPI AG
2021-03-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/6/1157 |
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| author | Judyta Mews Agata Tomaszewska Jacek Siewiera Sławomir Lewicki Karolina Kuczborska Agnieszka Lipińska-Opałka Bolesław Kalicki |
| author_facet | Judyta Mews Agata Tomaszewska Jacek Siewiera Sławomir Lewicki Karolina Kuczborska Agnieszka Lipińska-Opałka Bolesław Kalicki |
| author_sort | Judyta Mews |
| collection | DOAJ |
| description | In the course of atopic dermatitis (AD), the overactivity of the immune system, associated with predominant Th2 lymphocyte responses, is observed, which leads to an increased inflammatory reaction. Cases of a severe course of atopic dermatitis lead to the search for new therapeutic options. The aim of this study was to assess the effects of hyperbaric oxygen therapy (HBOT) treatment for severe cases of AD in children. A total of 15 children with severe AD underwent therapy. The influence of HBOT on the clinical course of AD and immunomodulatory effect of the therapy was analyzed by the SCORAD and objective SCORAD (oSCORAD) scales and by determining the serum concentration of immunological parameters (blood: nTreg lymphocytes, CD4+CD25highCD127-FOXP3+, NKT lymphocytes CD3+, CD16/56+, and serum: total IgE, cytokines IL-4, IL-6, and IL-10, before and after the 30-day treatment cycle). The study showed a significant effect of the therapy on the improvement of the skin condition. In all children, a reduction in the extent and intensity of skin lesions, reduction of redness, swelling, oozing/crusting, scratch marks and skin lichenification after HBOT was observed. Patients also reported a reduction in the intensity of pruritus and an improvement in sleep quality after therapy. In all children, a statistically significant decrease in the serum level of IgE was observed. However, no statistically significant changes in the blood levels of IL-4, IL-6 and IL-10, as well as the percentage of CD4<sup>+</sup>CD25<sup>high</sup>CD127<sup>−</sup>FOXP3<sup>+</sup> Treg and NKT lymphocytes, were found. In conclusion, the use of hyperbaric therapy has a positive impact on treatment results in children with a severe course of atopic dermatitis. |
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| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T13:22:23Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
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| spelling | doaj.art-8257a2fab2b04d56af6c88a3834b47462023-11-21T09:55:24ZengMDPI AGJournal of Clinical Medicine2077-03832021-03-01106115710.3390/jcm10061157Effects of Hyperbaric Oxygen Therapy in Children with Severe Atopic DermatitisJudyta Mews0Agata Tomaszewska1Jacek Siewiera2Sławomir Lewicki3Karolina Kuczborska4Agnieszka Lipińska-Opałka5Bolesław Kalicki6Department of Pediatrics, Nephrology and Allergology, Military Institute of Medicine, Szaserów 128 Str., 04-141 Warsaw, PolandDepartment of Pediatrics, Nephrology and Allergology, Military Institute of Medicine, Szaserów 128 Str., 04-141 Warsaw, PolandClinical Department of Hyperbaric Medicine, Military Institute of Medicine, 04-141 Warsaw, PolandDepartment of Regenerative Medicine and Cell Biology, Military Institute of Hygiene and Epidemiology, 04-141 Warsaw, PolandDepartment of Pediatrics, Nephrology and Allergology, Military Institute of Medicine, Szaserów 128 Str., 04-141 Warsaw, PolandDepartment of Pediatrics, Nephrology and Allergology, Military Institute of Medicine, Szaserów 128 Str., 04-141 Warsaw, PolandDepartment of Pediatrics, Nephrology and Allergology, Military Institute of Medicine, Szaserów 128 Str., 04-141 Warsaw, PolandIn the course of atopic dermatitis (AD), the overactivity of the immune system, associated with predominant Th2 lymphocyte responses, is observed, which leads to an increased inflammatory reaction. Cases of a severe course of atopic dermatitis lead to the search for new therapeutic options. The aim of this study was to assess the effects of hyperbaric oxygen therapy (HBOT) treatment for severe cases of AD in children. A total of 15 children with severe AD underwent therapy. The influence of HBOT on the clinical course of AD and immunomodulatory effect of the therapy was analyzed by the SCORAD and objective SCORAD (oSCORAD) scales and by determining the serum concentration of immunological parameters (blood: nTreg lymphocytes, CD4+CD25highCD127-FOXP3+, NKT lymphocytes CD3+, CD16/56+, and serum: total IgE, cytokines IL-4, IL-6, and IL-10, before and after the 30-day treatment cycle). The study showed a significant effect of the therapy on the improvement of the skin condition. In all children, a reduction in the extent and intensity of skin lesions, reduction of redness, swelling, oozing/crusting, scratch marks and skin lichenification after HBOT was observed. Patients also reported a reduction in the intensity of pruritus and an improvement in sleep quality after therapy. In all children, a statistically significant decrease in the serum level of IgE was observed. However, no statistically significant changes in the blood levels of IL-4, IL-6 and IL-10, as well as the percentage of CD4<sup>+</sup>CD25<sup>high</sup>CD127<sup>−</sup>FOXP3<sup>+</sup> Treg and NKT lymphocytes, were found. In conclusion, the use of hyperbaric therapy has a positive impact on treatment results in children with a severe course of atopic dermatitis.https://www.mdpi.com/2077-0383/10/6/1157atopic dermatitishyperbaric chamberimmune systemSCORADchildren |
| spellingShingle | Judyta Mews Agata Tomaszewska Jacek Siewiera Sławomir Lewicki Karolina Kuczborska Agnieszka Lipińska-Opałka Bolesław Kalicki Effects of Hyperbaric Oxygen Therapy in Children with Severe Atopic Dermatitis Journal of Clinical Medicine atopic dermatitis hyperbaric chamber immune system SCORAD children |
| title | Effects of Hyperbaric Oxygen Therapy in Children with Severe Atopic Dermatitis |
| title_full | Effects of Hyperbaric Oxygen Therapy in Children with Severe Atopic Dermatitis |
| title_fullStr | Effects of Hyperbaric Oxygen Therapy in Children with Severe Atopic Dermatitis |
| title_full_unstemmed | Effects of Hyperbaric Oxygen Therapy in Children with Severe Atopic Dermatitis |
| title_short | Effects of Hyperbaric Oxygen Therapy in Children with Severe Atopic Dermatitis |
| title_sort | effects of hyperbaric oxygen therapy in children with severe atopic dermatitis |
| topic | atopic dermatitis hyperbaric chamber immune system SCORAD children |
| url | https://www.mdpi.com/2077-0383/10/6/1157 |
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