Adherence to therapy and the risk of cardiovascular events in patients with heart failure: data from the outpatient registry
Aim. To determine the adherence to drug therapy and the prevalence of cardiovascular events (CVEs) in patients with heart failure (HF) after a 1-year follow-up in a specialized cardiology unit of a research center.Material and methods. CVEs were analyzed within the prospective observational study CO...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | Russian |
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«SILICEA-POLIGRAF» LLC
2022-11-01
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| Series: | Кардиоваскулярная терапия и профилактика |
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| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/3389 |
| _version_ | 1797882333987078144 |
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| author | E. T. Guseinova Yu. V. Lukina N. P. Kutishenko S. N. Tolpygina V. P. Voronina O. M. Drapkina S. Yu. Martsevich |
| author_facet | E. T. Guseinova Yu. V. Lukina N. P. Kutishenko S. N. Tolpygina V. P. Voronina O. M. Drapkina S. Yu. Martsevich |
| author_sort | E. T. Guseinova |
| collection | DOAJ |
| description | Aim. To determine the adherence to drug therapy and the prevalence of cardiovascular events (CVEs) in patients with heart failure (HF) after a 1-year follow-up in a specialized cardiology unit of a research center.Material and methods. CVEs were analyzed within the prospective observational study COMPLIANCE (Assessment of adherenСe tO Medical theraРy and its infLuence on long-term outcomes In pAtieNts with Chronic hEart failure in the outpatient registry). The study included 72 patients with HF, verified according to clinical guidelines. Patients were divided into 2 groups: adherent and non-adherent to treatment. Overall adherence to therapy and adherence to specific drugs were assessed using the original National Society for Evidence-Based PharmacotherapyAdherence Scale. The study included 2 visits: inclusion in the study and a visit after 1-year follow-up. After a 1-year follow-up, a comparative analysis of the two groups was performed to achieve the primary composite endpoint: death, acute cerebrovascular accident, myocardial infarction, decompensated HF with and without hospitalization.Results. A Kaplan-Meier analysis of 1-year survival showed that the mean time to onset of primary composite endpoint was 10,2 (95% confidence interval: 9,5-10,8) months. A significant relationship was found between the occurrence of composite endpoint and adherence to angiotensin-converting enzyme inhibitors/angiotensin receptor blockers (p=0,001), which was not confirmed for beta-blockers and mineralocorticoid receptor antagonists (p=0,338 and p=0,335, respectively). The risk of composite endpoint was 3,6 times higher in non-adherent patients than in adherent patients (hazard ratio, 3,6; 95% confidence interval, 1,5-8,5 (p=0,003)).Conclusion. A significant relationship was found between nonadherence to treatment and the incidence of CVEs, the risk of which increases by 3,6 times in non-adherent patients compared with adherent patients with HF. |
| first_indexed | 2024-04-10T03:33:08Z |
| format | Article |
| id | doaj.art-825807f3bbdb4d4aa2e1b262e1aab22c |
| institution | Directory Open Access Journal |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| last_indexed | 2024-04-10T03:33:08Z |
| publishDate | 2022-11-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj.art-825807f3bbdb4d4aa2e1b262e1aab22c2023-03-13T07:23:33Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252022-11-01211010.15829/1728-8800-2022-33892565Adherence to therapy and the risk of cardiovascular events in patients with heart failure: data from the outpatient registryE. T. Guseinova0Yu. V. Lukina1N. P. Kutishenko2S. N. Tolpygina3V. P. Voronina4O. M. Drapkina5S. Yu. Martsevich6ФГБУ Национальный медицинский исследовательский центр терапии и профилактической медицины Минздрава РоссииФГБУ Национальный медицинский исследовательский центр терапии и профилактической медицины Минздрава РоссииФГБУ Национальный медицинский исследовательский центр терапии и профилактической медицины Минздрава РоссииФГБУ Национальный медицинский исследовательский центр терапии и профилактической медицины Минздрава РоссииФГБУ Национальный медицинский исследовательский центр терапии и профилактической медицины Минздрава РоссииФГБУ Национальный медицинский исследовательский центр терапии и профилактической медицины Минздрава РоссииФГБУ Национальный медицинский исследовательский центр терапии и профилактической медицины Минздрава РоссииAim. To determine the adherence to drug therapy and the prevalence of cardiovascular events (CVEs) in patients with heart failure (HF) after a 1-year follow-up in a specialized cardiology unit of a research center.Material and methods. CVEs were analyzed within the prospective observational study COMPLIANCE (Assessment of adherenСe tO Medical theraРy and its infLuence on long-term outcomes In pAtieNts with Chronic hEart failure in the outpatient registry). The study included 72 patients with HF, verified according to clinical guidelines. Patients were divided into 2 groups: adherent and non-adherent to treatment. Overall adherence to therapy and adherence to specific drugs were assessed using the original National Society for Evidence-Based PharmacotherapyAdherence Scale. The study included 2 visits: inclusion in the study and a visit after 1-year follow-up. After a 1-year follow-up, a comparative analysis of the two groups was performed to achieve the primary composite endpoint: death, acute cerebrovascular accident, myocardial infarction, decompensated HF with and without hospitalization.Results. A Kaplan-Meier analysis of 1-year survival showed that the mean time to onset of primary composite endpoint was 10,2 (95% confidence interval: 9,5-10,8) months. A significant relationship was found between the occurrence of composite endpoint and adherence to angiotensin-converting enzyme inhibitors/angiotensin receptor blockers (p=0,001), which was not confirmed for beta-blockers and mineralocorticoid receptor antagonists (p=0,338 and p=0,335, respectively). The risk of composite endpoint was 3,6 times higher in non-adherent patients than in adherent patients (hazard ratio, 3,6; 95% confidence interval, 1,5-8,5 (p=0,003)).Conclusion. A significant relationship was found between nonadherence to treatment and the incidence of CVEs, the risk of which increases by 3,6 times in non-adherent patients compared with adherent patients with HF.https://cardiovascular.elpub.ru/jour/article/view/3389приверженность к лечениюхроническая сердечная недостаточностьсердечно-сосудистые событиярегистр |
| spellingShingle | E. T. Guseinova Yu. V. Lukina N. P. Kutishenko S. N. Tolpygina V. P. Voronina O. M. Drapkina S. Yu. Martsevich Adherence to therapy and the risk of cardiovascular events in patients with heart failure: data from the outpatient registry Кардиоваскулярная терапия и профилактика приверженность к лечению хроническая сердечная недостаточность сердечно-сосудистые события регистр |
| title | Adherence to therapy and the risk of cardiovascular events in patients with heart failure: data from the outpatient registry |
| title_full | Adherence to therapy and the risk of cardiovascular events in patients with heart failure: data from the outpatient registry |
| title_fullStr | Adherence to therapy and the risk of cardiovascular events in patients with heart failure: data from the outpatient registry |
| title_full_unstemmed | Adherence to therapy and the risk of cardiovascular events in patients with heart failure: data from the outpatient registry |
| title_short | Adherence to therapy and the risk of cardiovascular events in patients with heart failure: data from the outpatient registry |
| title_sort | adherence to therapy and the risk of cardiovascular events in patients with heart failure data from the outpatient registry |
| topic | приверженность к лечению хроническая сердечная недостаточность сердечно-сосудистые события регистр |
| url | https://cardiovascular.elpub.ru/jour/article/view/3389 |
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