Brain Activity in Different Brain Areas of Patients With Dry Eye During the Female Climacteric Period According to Voxel-Based Morphometry
We aim to investigate potential morphological alterations of the brain in female climacteric patients with dry eye (DE) and their relationship to behavioral performances. Twenty-five female patients with DE disease during the female climacteric period and 25 age and education-matched healthy control...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2022.879444/full |
| _version_ | 1818551388587687936 |
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| author | Meng-Yan Hu Li-Juan Zhang Min Kang Yi-Cong Pan Qian-min Ge Qiu-yu Li Lin Yang Chong-Gang Pei Yi Shao |
| author_facet | Meng-Yan Hu Li-Juan Zhang Min Kang Yi-Cong Pan Qian-min Ge Qiu-yu Li Lin Yang Chong-Gang Pei Yi Shao |
| author_sort | Meng-Yan Hu |
| collection | DOAJ |
| description | We aim to investigate potential morphological alterations of the brain in female climacteric patients with dry eye (DE) and their relationship to behavioral performances. Twenty-five female patients with DE disease during the female climacteric period and 25 age and education-matched healthy controls (HCs) underwent magnetic resonance imaging. Imaging data were analyzed using voxel-based morphometry (VBM) to identify group differences in DE patients and HCs. Compared with HCs, patients with DE during the female climacteric period had significantly decreased VBM in the Putamen_L, Thalamus_R, Precuneus_L, Frontal_Sup_R, Cingulum_Mid_L, and Frontal_Mid_L. There was increased VBM in the Temporal_Pole_Sup_R, Precentral_R and Insula_L. Receiver operating characteristic curve analysis indicated that the VBM method has clear potential for diagnosis of DE patients during the climacteric period. Correlation analysis found a negative correlation between the VBM values of the Putamen_L and the anxiety score (AS) and depression score (DS), a positive correlation was found between VBM values of the Temporal_Pole_Sup_R and AS. Moreover, VBM values in the Cingulum_Mid_L were positively correlated with AS and DS. These results revealed abnormal spontaneous activity in the brain regions of patients with DE during the climacteric period, which may indicate underlying pathological mechanisms. These results may help to advance clinical treatments. |
| first_indexed | 2024-12-12T08:59:15Z |
| format | Article |
| id | doaj.art-825896de08aa4ad3aee62b53e8b7abeb |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-12T08:59:15Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-825896de08aa4ad3aee62b53e8b7abeb2022-12-22T00:29:53ZengFrontiers Media S.A.Frontiers in Neurology1664-22952022-05-011310.3389/fneur.2022.879444879444Brain Activity in Different Brain Areas of Patients With Dry Eye During the Female Climacteric Period According to Voxel-Based MorphometryMeng-Yan HuLi-Juan ZhangMin KangYi-Cong PanQian-min GeQiu-yu LiLin YangChong-Gang PeiYi ShaoWe aim to investigate potential morphological alterations of the brain in female climacteric patients with dry eye (DE) and their relationship to behavioral performances. Twenty-five female patients with DE disease during the female climacteric period and 25 age and education-matched healthy controls (HCs) underwent magnetic resonance imaging. Imaging data were analyzed using voxel-based morphometry (VBM) to identify group differences in DE patients and HCs. Compared with HCs, patients with DE during the female climacteric period had significantly decreased VBM in the Putamen_L, Thalamus_R, Precuneus_L, Frontal_Sup_R, Cingulum_Mid_L, and Frontal_Mid_L. There was increased VBM in the Temporal_Pole_Sup_R, Precentral_R and Insula_L. Receiver operating characteristic curve analysis indicated that the VBM method has clear potential for diagnosis of DE patients during the climacteric period. Correlation analysis found a negative correlation between the VBM values of the Putamen_L and the anxiety score (AS) and depression score (DS), a positive correlation was found between VBM values of the Temporal_Pole_Sup_R and AS. Moreover, VBM values in the Cingulum_Mid_L were positively correlated with AS and DS. These results revealed abnormal spontaneous activity in the brain regions of patients with DE during the climacteric period, which may indicate underlying pathological mechanisms. These results may help to advance clinical treatments.https://www.frontiersin.org/articles/10.3389/fneur.2022.879444/fullvoxel-based morphometrymagnetic resonance imaginggray matter densitydry eye diseaseclimacteric period |
| spellingShingle | Meng-Yan Hu Li-Juan Zhang Min Kang Yi-Cong Pan Qian-min Ge Qiu-yu Li Lin Yang Chong-Gang Pei Yi Shao Brain Activity in Different Brain Areas of Patients With Dry Eye During the Female Climacteric Period According to Voxel-Based Morphometry Frontiers in Neurology voxel-based morphometry magnetic resonance imaging gray matter density dry eye disease climacteric period |
| title | Brain Activity in Different Brain Areas of Patients With Dry Eye During the Female Climacteric Period According to Voxel-Based Morphometry |
| title_full | Brain Activity in Different Brain Areas of Patients With Dry Eye During the Female Climacteric Period According to Voxel-Based Morphometry |
| title_fullStr | Brain Activity in Different Brain Areas of Patients With Dry Eye During the Female Climacteric Period According to Voxel-Based Morphometry |
| title_full_unstemmed | Brain Activity in Different Brain Areas of Patients With Dry Eye During the Female Climacteric Period According to Voxel-Based Morphometry |
| title_short | Brain Activity in Different Brain Areas of Patients With Dry Eye During the Female Climacteric Period According to Voxel-Based Morphometry |
| title_sort | brain activity in different brain areas of patients with dry eye during the female climacteric period according to voxel based morphometry |
| topic | voxel-based morphometry magnetic resonance imaging gray matter density dry eye disease climacteric period |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2022.879444/full |
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