Brachytherapy of stage II mobile tongue carcinoma. Prediction of local control and QOL
<p>Abstract</p> <p>Background</p> <p>There is no consensus as to the prognostic model for brachytherapy of tongue carcinoma. This study was designed to evaluate the prognostic factors for local control based on a large population under a unified treatment policy.</p&...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2006-07-01
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| Series: | Radiation Oncology |
| Online Access: | http://www.ro-journal.com/content/1/1/21 |
| Summary: | <p>Abstract</p> <p>Background</p> <p>There is no consensus as to the prognostic model for brachytherapy of tongue carcinoma. This study was designed to evaluate the prognostic factors for local control based on a large population under a unified treatment policy.</p> <p>Results</p> <p>Between 1970 and 1998, 433 patients with stage II tongue squamous cell carcinoma were treated by low-dose-rate brachytherapy. This series included 277 patients treated with a linear source with a minimum follow-up of 3 years. A spacer was introduced in 1987. The primary local control rates were 85.6%.</p> <p>Conclusion</p> <p>In the multivariate analysis, an invasive growth pattern was a significant factor for local recurrence. The disease-related survival was influenced by old age and an invasive growth pattern. A spacer lowered mandibular bone complications. The growth pattern was the most important factor for recurrence. Brachytherapy was associated with a high cure rate and the use of spacers brought about good quality of life (QOL).</p> |
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| ISSN: | 1748-717X |