Cellular and molecular mechanisms of inflammation of esophageal mucosa under different clinical course of gastroesophageal reflux disease and its complications
The review presents modern data on the cellular and molecular mechanisms of inflammatory changes of esophageal mucosa exposed to different types of reluctate (gastric, biliary or duodenal/mixed). The authors describe data on key mediators of inflammation in gastroesophageal reflux disease (GERD) and...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
"Consilium Medicum" Publishing house
2018-02-01
|
| Series: | Терапевтический архив |
| Subjects: | |
| Online Access: | https://ter-arkhiv.ru/0040-3660/article/viewFile/32837/pdf |
| _version_ | 1818772805202739200 |
|---|---|
| author | S V Lyamina I V Maev O V Kladovikova I Yu Malyshev |
| author_facet | S V Lyamina I V Maev O V Kladovikova I Yu Malyshev |
| author_sort | S V Lyamina |
| collection | DOAJ |
| description | The review presents modern data on the cellular and molecular mechanisms of inflammatory changes of esophageal mucosa exposed to different types of reluctate (gastric, biliary or duodenal/mixed). The authors describe data on key mediators of inflammation in gastroesophageal reflux disease (GERD) and their major cellular sources, changes of the immune profile of patients. Discusses the possible impact of changes in the cellular and molecular components in the development of the inflammatory response in the esophagus on the clinical features of GERD and its therapy-refractory forms. |
| first_indexed | 2024-12-18T10:15:11Z |
| format | Article |
| id | doaj.art-8259785d0d544040bdb1625f7453dcdc |
| institution | Directory Open Access Journal |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| last_indexed | 2024-12-18T10:15:11Z |
| publishDate | 2018-02-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj.art-8259785d0d544040bdb1625f7453dcdc2022-12-21T21:11:19Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422018-02-01902798429588Cellular and molecular mechanisms of inflammation of esophageal mucosa under different clinical course of gastroesophageal reflux disease and its complicationsS V Lyamina0I V Maev1O V Kladovikova2I Yu Malyshev3A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of RussiaA.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of RussiaA.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of RussiaA.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of RussiaThe review presents modern data on the cellular and molecular mechanisms of inflammatory changes of esophageal mucosa exposed to different types of reluctate (gastric, biliary or duodenal/mixed). The authors describe data on key mediators of inflammation in gastroesophageal reflux disease (GERD) and their major cellular sources, changes of the immune profile of patients. Discusses the possible impact of changes in the cellular and molecular components in the development of the inflammatory response in the esophagus on the clinical features of GERD and its therapy-refractory forms.https://ter-arkhiv.ru/0040-3660/article/viewFile/32837/pdfgastroesophageal reflux diseasebarrett's esophagusph-metryinflammationrefluxfibrogenesiscytokinesmacrophagesthe phenotype of macrophages |
| spellingShingle | S V Lyamina I V Maev O V Kladovikova I Yu Malyshev Cellular and molecular mechanisms of inflammation of esophageal mucosa under different clinical course of gastroesophageal reflux disease and its complications Терапевтический архив gastroesophageal reflux disease barrett's esophagus ph-metry inflammation reflux fibrogenesis cytokines macrophages the phenotype of macrophages |
| title | Cellular and molecular mechanisms of inflammation of esophageal mucosa under different clinical course of gastroesophageal reflux disease and its complications |
| title_full | Cellular and molecular mechanisms of inflammation of esophageal mucosa under different clinical course of gastroesophageal reflux disease and its complications |
| title_fullStr | Cellular and molecular mechanisms of inflammation of esophageal mucosa under different clinical course of gastroesophageal reflux disease and its complications |
| title_full_unstemmed | Cellular and molecular mechanisms of inflammation of esophageal mucosa under different clinical course of gastroesophageal reflux disease and its complications |
| title_short | Cellular and molecular mechanisms of inflammation of esophageal mucosa under different clinical course of gastroesophageal reflux disease and its complications |
| title_sort | cellular and molecular mechanisms of inflammation of esophageal mucosa under different clinical course of gastroesophageal reflux disease and its complications |
| topic | gastroesophageal reflux disease barrett's esophagus ph-metry inflammation reflux fibrogenesis cytokines macrophages the phenotype of macrophages |
| url | https://ter-arkhiv.ru/0040-3660/article/viewFile/32837/pdf |
| work_keys_str_mv | AT svlyamina cellularandmolecularmechanismsofinflammationofesophagealmucosaunderdifferentclinicalcourseofgastroesophagealrefluxdiseaseanditscomplications AT ivmaev cellularandmolecularmechanismsofinflammationofesophagealmucosaunderdifferentclinicalcourseofgastroesophagealrefluxdiseaseanditscomplications AT ovkladovikova cellularandmolecularmechanismsofinflammationofesophagealmucosaunderdifferentclinicalcourseofgastroesophagealrefluxdiseaseanditscomplications AT iyumalyshev cellularandmolecularmechanismsofinflammationofesophagealmucosaunderdifferentclinicalcourseofgastroesophagealrefluxdiseaseanditscomplications |