Novel TrxR1 Inhibitors Show Potential for Glioma Treatment by Suppressing the Invasion and Sensitizing Glioma Cells to Chemotherapy

Novel TrxR1 Inhibitors Show Potential for Glioma Treatment by Suppressing the Invasion and Sensitizing Glioma Cells to Chemotherapy

Currently, available glioblastoma (GBM) treatment remains ineffective, with relapse after initial response and low survival rate of GBM patients. The reasons behind limited capacities for GBM treatment are high tumor heterogeneity, invasiveness, and occurrence of drug resistance. Therefore, developi...

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Bibliographic Details
Main Authors: Mirna Jovanović, Miodrag Dragoj, Daniil Zhukovsky, Dmitry Dar’in, Mikhail Krasavin, Milica Pešić, Ana Podolski-Renić
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Molecular Biosciences
Subjects:
glioma
multidrug resistance
thioredoxin reductase 1
oxidative stress
temozolomide
invasion
Online Access:https://www.frontiersin.org/article/10.3389/fmolb.2020.586146/full

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