The epidemic characteristics and changing trend of hemorrhagic fever with renal syndrome in Hubei Province, China.
BACKGROUND: Hemorrhagic fever with renal syndrome (HFRS) is caused by different hantaviruses within the Bunyaviridae family. HFRS is a fulminant, infectious disease that occurs worldwide and is endemic in all 31 provinces of China. Since the first HFRS case in Hubei Province was reported in 1957, th...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3962441?pdf=render |
| _version_ | 1818701142373171200 |
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| author | Yi-Hui Zhang Liang Ge Li Liu Xi-Xiang Huo Hai-Rong Xiong Yuan-Yuan Liu Dong-Ying Liu Fan Luo Jin-Lin Li Jia-Xin Ling Wen Chen Jing Liu Wei Hou Yun Zhang Hong Fan Zhan-Qiu Yang |
| author_facet | Yi-Hui Zhang Liang Ge Li Liu Xi-Xiang Huo Hai-Rong Xiong Yuan-Yuan Liu Dong-Ying Liu Fan Luo Jin-Lin Li Jia-Xin Ling Wen Chen Jing Liu Wei Hou Yun Zhang Hong Fan Zhan-Qiu Yang |
| author_sort | Yi-Hui Zhang |
| collection | DOAJ |
| description | BACKGROUND: Hemorrhagic fever with renal syndrome (HFRS) is caused by different hantaviruses within the Bunyaviridae family. HFRS is a fulminant, infectious disease that occurs worldwide and is endemic in all 31 provinces of China. Since the first HFRS case in Hubei Province was reported in 1957, the disease has spread across the province and Hubei has become one of the seriously affected areas in China with the greatest number of reported HFRS cases in the 1980's. However, the epidemic characteristics of HFRS in Hubei are still not entirely clear and long-term, systematic investigations of this epidemic area have been very limited. METHODS: The spatiotemporal distribution of HFRS was investigated using data spanning the years 1980 to 2009. The annual HFRS incidence, fatality rate and seasonal incidence between 1980 and 2009 were calculated and plotted. GIS-based spatial analyses were conducted to detect the spatial distribution and seasonal pattern of HFRS. A spatial statistical analysis, using Kulldorff's spatial scan statistic, was performed to identify clustering of HFRS. RESULTS: A total of 104,467 HFRS cases were reported in Hubei Province between 1980 and 2009. Incidence of and mortality due to HFRS declined after the outbreak in 1980s and HFRS cases have been sporadic in recent years. The locations and scale of disease clusters have changed during the three decades. The seasonal epidemic pattern of HFRS was characterized by the shift from the unimodal type (autumn/winter peak) to the bimodal type. CONCLUSIONS: Socioeconomic development has great influence on the transmission of hantaviruses to humans and new epidemic characteristics have emerged in Hubei Province. It is necessary to reinforce preventative measures against HFRS according to the newly-presented seasonal variation and to intensify these efforts especially in the urban areas of Hubei Province. |
| first_indexed | 2024-12-17T15:16:08Z |
| format | Article |
| id | doaj.art-825afb31c5e949cdafd4a4fd352c8495 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-17T15:16:08Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-825afb31c5e949cdafd4a4fd352c84952022-12-21T21:43:32ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0193e9270010.1371/journal.pone.0092700The epidemic characteristics and changing trend of hemorrhagic fever with renal syndrome in Hubei Province, China.Yi-Hui ZhangLiang GeLi LiuXi-Xiang HuoHai-Rong XiongYuan-Yuan LiuDong-Ying LiuFan LuoJin-Lin LiJia-Xin LingWen ChenJing LiuWei HouYun ZhangHong FanZhan-Qiu YangBACKGROUND: Hemorrhagic fever with renal syndrome (HFRS) is caused by different hantaviruses within the Bunyaviridae family. HFRS is a fulminant, infectious disease that occurs worldwide and is endemic in all 31 provinces of China. Since the first HFRS case in Hubei Province was reported in 1957, the disease has spread across the province and Hubei has become one of the seriously affected areas in China with the greatest number of reported HFRS cases in the 1980's. However, the epidemic characteristics of HFRS in Hubei are still not entirely clear and long-term, systematic investigations of this epidemic area have been very limited. METHODS: The spatiotemporal distribution of HFRS was investigated using data spanning the years 1980 to 2009. The annual HFRS incidence, fatality rate and seasonal incidence between 1980 and 2009 were calculated and plotted. GIS-based spatial analyses were conducted to detect the spatial distribution and seasonal pattern of HFRS. A spatial statistical analysis, using Kulldorff's spatial scan statistic, was performed to identify clustering of HFRS. RESULTS: A total of 104,467 HFRS cases were reported in Hubei Province between 1980 and 2009. Incidence of and mortality due to HFRS declined after the outbreak in 1980s and HFRS cases have been sporadic in recent years. The locations and scale of disease clusters have changed during the three decades. The seasonal epidemic pattern of HFRS was characterized by the shift from the unimodal type (autumn/winter peak) to the bimodal type. CONCLUSIONS: Socioeconomic development has great influence on the transmission of hantaviruses to humans and new epidemic characteristics have emerged in Hubei Province. It is necessary to reinforce preventative measures against HFRS according to the newly-presented seasonal variation and to intensify these efforts especially in the urban areas of Hubei Province.http://europepmc.org/articles/PMC3962441?pdf=render |
| spellingShingle | Yi-Hui Zhang Liang Ge Li Liu Xi-Xiang Huo Hai-Rong Xiong Yuan-Yuan Liu Dong-Ying Liu Fan Luo Jin-Lin Li Jia-Xin Ling Wen Chen Jing Liu Wei Hou Yun Zhang Hong Fan Zhan-Qiu Yang The epidemic characteristics and changing trend of hemorrhagic fever with renal syndrome in Hubei Province, China. PLoS ONE |
| title | The epidemic characteristics and changing trend of hemorrhagic fever with renal syndrome in Hubei Province, China. |
| title_full | The epidemic characteristics and changing trend of hemorrhagic fever with renal syndrome in Hubei Province, China. |
| title_fullStr | The epidemic characteristics and changing trend of hemorrhagic fever with renal syndrome in Hubei Province, China. |
| title_full_unstemmed | The epidemic characteristics and changing trend of hemorrhagic fever with renal syndrome in Hubei Province, China. |
| title_short | The epidemic characteristics and changing trend of hemorrhagic fever with renal syndrome in Hubei Province, China. |
| title_sort | epidemic characteristics and changing trend of hemorrhagic fever with renal syndrome in hubei province china |
| url | http://europepmc.org/articles/PMC3962441?pdf=render |
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