Myoferlin targeting triggers mitophagy and primes ferroptosis in pancreatic cancer cells

Myoferlin targeting triggers mitophagy and primes ferroptosis in pancreatic cancer cells

Myoferlin, an emerging oncoprotein, has been associated with a low survival in several cancer types including pancreas ductal adenocarcinoma where it controls mitochondria structure and respiratory functions. Owing to the high susceptibility of KRAS-mutated cancer cells to iron-dependent cell death,...

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Bibliographic Details
Main Authors: Gilles Rademaker, Yasmine Boumahd, Raphaël Peiffer, Sandy Anania, Tom Wissocq, Maude Liégeois, Géraldine Luis, Nor Eddine Sounni, Ferman Agirman, Naïma Maloujahmoum, Pascal De Tullio, Marc Thiry, Akeila Bellahcène, Vincent Castronovo, Olivier Peulen
Format: Article
Language:English
Published: Elsevier 2022-07-01
Series:Redox Biology
Subjects:
Myoferlin
Ferroptosis
Mitochondria
Pancreas cancer
Mitophagy
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231722000969

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http://www.sciencedirect.com/science/article/pii/S2213231722000969

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