Haptoglobin and Its Related Protein, Zonulin—What Is Their Role in Spondyloarthropathy?
Haptoglobin (Hp) is an acute phase protein which supports the immune response and protects tissues from free radicals. Its concentration correlates with disease activity in spondyloarthropathies (SpAs). The Hp polymorphism determines the functional differences between Hp1 and Hp2 protein products. T...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/5/1131 |
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| author | Magdalena Chmielińska Marzena Olesińska Katarzyna Romanowska-Próchnicka Dariusz Szukiewicz |
| author_facet | Magdalena Chmielińska Marzena Olesińska Katarzyna Romanowska-Próchnicka Dariusz Szukiewicz |
| author_sort | Magdalena Chmielińska |
| collection | DOAJ |
| description | Haptoglobin (Hp) is an acute phase protein which supports the immune response and protects tissues from free radicals. Its concentration correlates with disease activity in spondyloarthropathies (SpAs). The Hp polymorphism determines the functional differences between Hp1 and Hp2 protein products. The role of the Hp polymorphism has been demonstrated in many diseases. In particular, the Hp 2-2 phenotype has been associated with the unfavorable course of some inflammatory and autoimmune disorders. Its potential role in modulating the immune system in SpA is still unknown. This article contains pathophysiological considerations on the potential relationship between Hp, its polymorphism and SpA. |
| first_indexed | 2024-03-10T13:27:11Z |
| format | Article |
| id | doaj.art-825c31af47414ea58cdb750ab34d750e |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T13:27:11Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-825c31af47414ea58cdb750ab34d750e2023-11-21T09:36:08ZengMDPI AGJournal of Clinical Medicine2077-03832021-03-01105113110.3390/jcm10051131Haptoglobin and Its Related Protein, Zonulin—What Is Their Role in Spondyloarthropathy?Magdalena Chmielińska0Marzena Olesińska1Katarzyna Romanowska-Próchnicka2Dariusz Szukiewicz3Department of Biophysics and Human Physiology, Medical University of Warsaw, Chałubińskiego 5, 02-004 Warsaw, PolandDepartment of Connective Tissue Diseases, National Institute of Geriatrics, Rheumatology and Rehabilitation, Spartańska 1, 02-637 Warsaw, PolandDepartment of Biophysics and Human Physiology, Medical University of Warsaw, Chałubińskiego 5, 02-004 Warsaw, PolandDepartment of Biophysics and Human Physiology, Medical University of Warsaw, Chałubińskiego 5, 02-004 Warsaw, PolandHaptoglobin (Hp) is an acute phase protein which supports the immune response and protects tissues from free radicals. Its concentration correlates with disease activity in spondyloarthropathies (SpAs). The Hp polymorphism determines the functional differences between Hp1 and Hp2 protein products. The role of the Hp polymorphism has been demonstrated in many diseases. In particular, the Hp 2-2 phenotype has been associated with the unfavorable course of some inflammatory and autoimmune disorders. Its potential role in modulating the immune system in SpA is still unknown. This article contains pathophysiological considerations on the potential relationship between Hp, its polymorphism and SpA.https://www.mdpi.com/2077-0383/10/5/1131haptoglobin polymorphisminflammationpathogenesisspondyloarthropathyzonulin |
| spellingShingle | Magdalena Chmielińska Marzena Olesińska Katarzyna Romanowska-Próchnicka Dariusz Szukiewicz Haptoglobin and Its Related Protein, Zonulin—What Is Their Role in Spondyloarthropathy? Journal of Clinical Medicine haptoglobin polymorphism inflammation pathogenesis spondyloarthropathy zonulin |
| title | Haptoglobin and Its Related Protein, Zonulin—What Is Their Role in Spondyloarthropathy? |
| title_full | Haptoglobin and Its Related Protein, Zonulin—What Is Their Role in Spondyloarthropathy? |
| title_fullStr | Haptoglobin and Its Related Protein, Zonulin—What Is Their Role in Spondyloarthropathy? |
| title_full_unstemmed | Haptoglobin and Its Related Protein, Zonulin—What Is Their Role in Spondyloarthropathy? |
| title_short | Haptoglobin and Its Related Protein, Zonulin—What Is Their Role in Spondyloarthropathy? |
| title_sort | haptoglobin and its related protein zonulin what is their role in spondyloarthropathy |
| topic | haptoglobin polymorphism inflammation pathogenesis spondyloarthropathy zonulin |
| url | https://www.mdpi.com/2077-0383/10/5/1131 |
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