A Three-Month Consumption of Eggs Enriched with ω-3, ω-5 and ω-7 Polyunsaturated Fatty Acids Significantly Decreases the Waist Circumference of Subjects at Risk of Developing Metabolic Syndrome: A Double-Blind Randomized Controlled Trial
Alpha-linolenic acid (ALA), docosahexaenoic acid (DHA), rumenic acid (RmA), and punicic acid (PunA) are claimed to influence several physiological functions including insulin sensitivity, lipid metabolism and inflammatory processes. In this double-blind randomized controlled trial, we investigated t...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/13/2/663 |
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| author | Monique T. Ngo Njembe Barbara Pachikian Irina Lobysheva Nancy Van Overstraeten Louis Dejonghe Eleonore Verstraelen Marine Buchet Catherine Rasse Cécile Gardin Eric Mignolet Jean-Luc Balligand Yvan Larondelle |
| author_facet | Monique T. Ngo Njembe Barbara Pachikian Irina Lobysheva Nancy Van Overstraeten Louis Dejonghe Eleonore Verstraelen Marine Buchet Catherine Rasse Cécile Gardin Eric Mignolet Jean-Luc Balligand Yvan Larondelle |
| author_sort | Monique T. Ngo Njembe |
| collection | DOAJ |
| description | Alpha-linolenic acid (ALA), docosahexaenoic acid (DHA), rumenic acid (RmA), and punicic acid (PunA) are claimed to influence several physiological functions including insulin sensitivity, lipid metabolism and inflammatory processes. In this double-blind randomized controlled trial, we investigated the combined effect of ALA, DHA, RmA and PunA on subjects at risk of developing metabolic syndrome. Twenty-four women and men were randomly assigned to two groups. Each day, they consumed two eggs enriched with oleic acid (control group) or enriched with ALA, DHA, RmA, and PunA (test group) for 3 months. The waist circumference decreased significantly (−3.17 cm; <i>p</i> < 0.001) in the test group. There were no major changes in plasma insulin and blood glucose in the two groups. The dietary treatments had no significant effect on endothelial function as measured by peripheral arterial tonometry, although erythrocyte nitrosylated hemoglobin concentrations tended to decrease. The high consumption of eggs induced significant elevations in plasma low-density lipoprotein (LDL)- and high-density lipoprotein (HDL)-cholesterol (<i>p</i> < 0.001), which did not result in any change in the LDL/HDL ratio in both groups. These results indicate that consumption of eggs enriched with ALA, DHA, RmA and PunA resulted in favorable changes in abdominal obesity without affecting other factors of the metabolic syndrome. |
| first_indexed | 2024-03-09T00:45:45Z |
| format | Article |
| id | doaj.art-825d12f3e8944f57bdc1e4cf833cd2c4 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T00:45:45Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-825d12f3e8944f57bdc1e4cf833cd2c42023-12-11T17:32:43ZengMDPI AGNutrients2072-66432021-02-0113266310.3390/nu13020663A Three-Month Consumption of Eggs Enriched with ω-3, ω-5 and ω-7 Polyunsaturated Fatty Acids Significantly Decreases the Waist Circumference of Subjects at Risk of Developing Metabolic Syndrome: A Double-Blind Randomized Controlled TrialMonique T. Ngo Njembe0Barbara Pachikian1Irina Lobysheva2Nancy Van Overstraeten3Louis Dejonghe4Eleonore Verstraelen5Marine Buchet6Catherine Rasse7Cécile Gardin8Eric Mignolet9Jean-Luc Balligand10Yvan Larondelle11Louvain Institute of Biomolecular Science and Technology, UCLouvain, 1348 Louvain-la-Neuve, BelgiumCenter of Investigation in Clinical Nutrition, UCLouvain, 1348 Louvain-la-Neuve, BelgiumInstitute of Experimental and Clinical Research, Pole of Pharmacology and Therapeutics, UCLouvain, 1200 Woluwe-Saint-Lambert, BelgiumInstitute of Experimental and Clinical Research, Pole of Pharmacology and Therapeutics, UCLouvain, 1200 Woluwe-Saint-Lambert, BelgiumLouvain Institute of Biomolecular Science and Technology, UCLouvain, 1348 Louvain-la-Neuve, BelgiumLouvain Institute of Biomolecular Science and Technology, UCLouvain, 1348 Louvain-la-Neuve, BelgiumLouvain Institute of Biomolecular Science and Technology, UCLouvain, 1348 Louvain-la-Neuve, BelgiumLouvain Institute of Data Analysis and Modeling in economics and statistics, Statistical Methodology and Computing Service, UCLouvain, 1348 Louvain-la-Neuve, BelgiumLouvain Institute of Biomolecular Science and Technology, UCLouvain, 1348 Louvain-la-Neuve, BelgiumLouvain Institute of Biomolecular Science and Technology, UCLouvain, 1348 Louvain-la-Neuve, BelgiumInstitute of Experimental and Clinical Research, Pole of Pharmacology and Therapeutics, UCLouvain, 1200 Woluwe-Saint-Lambert, BelgiumLouvain Institute of Biomolecular Science and Technology, UCLouvain, 1348 Louvain-la-Neuve, BelgiumAlpha-linolenic acid (ALA), docosahexaenoic acid (DHA), rumenic acid (RmA), and punicic acid (PunA) are claimed to influence several physiological functions including insulin sensitivity, lipid metabolism and inflammatory processes. In this double-blind randomized controlled trial, we investigated the combined effect of ALA, DHA, RmA and PunA on subjects at risk of developing metabolic syndrome. Twenty-four women and men were randomly assigned to two groups. Each day, they consumed two eggs enriched with oleic acid (control group) or enriched with ALA, DHA, RmA, and PunA (test group) for 3 months. The waist circumference decreased significantly (−3.17 cm; <i>p</i> < 0.001) in the test group. There were no major changes in plasma insulin and blood glucose in the two groups. The dietary treatments had no significant effect on endothelial function as measured by peripheral arterial tonometry, although erythrocyte nitrosylated hemoglobin concentrations tended to decrease. The high consumption of eggs induced significant elevations in plasma low-density lipoprotein (LDL)- and high-density lipoprotein (HDL)-cholesterol (<i>p</i> < 0.001), which did not result in any change in the LDL/HDL ratio in both groups. These results indicate that consumption of eggs enriched with ALA, DHA, RmA and PunA resulted in favorable changes in abdominal obesity without affecting other factors of the metabolic syndrome.https://www.mdpi.com/2072-6643/13/2/663Alpha-linolenic aciddocosahexaenoic acidrumenic acidpunicic acidenriched eggsmetabolic syndrome |
| spellingShingle | Monique T. Ngo Njembe Barbara Pachikian Irina Lobysheva Nancy Van Overstraeten Louis Dejonghe Eleonore Verstraelen Marine Buchet Catherine Rasse Cécile Gardin Eric Mignolet Jean-Luc Balligand Yvan Larondelle A Three-Month Consumption of Eggs Enriched with ω-3, ω-5 and ω-7 Polyunsaturated Fatty Acids Significantly Decreases the Waist Circumference of Subjects at Risk of Developing Metabolic Syndrome: A Double-Blind Randomized Controlled Trial Nutrients Alpha-linolenic acid docosahexaenoic acid rumenic acid punicic acid enriched eggs metabolic syndrome |
| title | A Three-Month Consumption of Eggs Enriched with ω-3, ω-5 and ω-7 Polyunsaturated Fatty Acids Significantly Decreases the Waist Circumference of Subjects at Risk of Developing Metabolic Syndrome: A Double-Blind Randomized Controlled Trial |
| title_full | A Three-Month Consumption of Eggs Enriched with ω-3, ω-5 and ω-7 Polyunsaturated Fatty Acids Significantly Decreases the Waist Circumference of Subjects at Risk of Developing Metabolic Syndrome: A Double-Blind Randomized Controlled Trial |
| title_fullStr | A Three-Month Consumption of Eggs Enriched with ω-3, ω-5 and ω-7 Polyunsaturated Fatty Acids Significantly Decreases the Waist Circumference of Subjects at Risk of Developing Metabolic Syndrome: A Double-Blind Randomized Controlled Trial |
| title_full_unstemmed | A Three-Month Consumption of Eggs Enriched with ω-3, ω-5 and ω-7 Polyunsaturated Fatty Acids Significantly Decreases the Waist Circumference of Subjects at Risk of Developing Metabolic Syndrome: A Double-Blind Randomized Controlled Trial |
| title_short | A Three-Month Consumption of Eggs Enriched with ω-3, ω-5 and ω-7 Polyunsaturated Fatty Acids Significantly Decreases the Waist Circumference of Subjects at Risk of Developing Metabolic Syndrome: A Double-Blind Randomized Controlled Trial |
| title_sort | three month consumption of eggs enriched with ω 3 ω 5 and ω 7 polyunsaturated fatty acids significantly decreases the waist circumference of subjects at risk of developing metabolic syndrome a double blind randomized controlled trial |
| topic | Alpha-linolenic acid docosahexaenoic acid rumenic acid punicic acid enriched eggs metabolic syndrome |
| url | https://www.mdpi.com/2072-6643/13/2/663 |
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