Rapid determination of pesticide residues in Chinese materia medica using QuEChERS sample preparation followed by gas chromatography–mass spectrometry
Pesticide residue analysis plays an important role in the quality control of Chinese materia medica. This paper reports the development and validation of an analytical method for the quantitative determination of the residues of 39 pesticides in 12 different matrices of Chinese materia medica. Sampl...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2012-06-01
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| Series: | Acta Pharmaceutica Sinica B |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211383512000536 |
| _version_ | 1811261629943250944 |
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| author | Yichen Hu Li Wan Jinming Zhang Fang Yang Jiliang Cao |
| author_facet | Yichen Hu Li Wan Jinming Zhang Fang Yang Jiliang Cao |
| author_sort | Yichen Hu |
| collection | DOAJ |
| description | Pesticide residue analysis plays an important role in the quality control of Chinese materia medica. This paper reports the development and validation of an analytical method for the quantitative determination of the residues of 39 pesticides in 12 different matrices of Chinese materia medica. Sample preparation utilized the QuEChERS method with acetonitrile:1% aqueous acetic acid (9:1, v/v) as extraction solvent followed by sample clean-up by dispersive solid phase extraction using primary secondary amine sorbent and graphitized carbon black. Extracts were then analysed by gas chromatography coupled with electron impact mass spectrometry in the selected ion monitoring mode. Limit of detection (LOD) and limit of quantitation (LOQ) values were in the ranges 0.5–50 ng/g and 1–100 ng/g, respectively. The recoveries of the 39 pesticides were in the range 75–112% with precision (as relative standard deviation, RSD) <15%. The results show that the modified QuEChERS method allows rapid and sensitive analysis of multiple pesticide residues in Chinese materia medica. |
| first_indexed | 2024-04-12T19:08:07Z |
| format | Article |
| id | doaj.art-825d7650251d4fcca72ee8e8b614e8f9 |
| institution | Directory Open Access Journal |
| issn | 2211-3835 2211-3843 |
| language | English |
| last_indexed | 2024-04-12T19:08:07Z |
| publishDate | 2012-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Acta Pharmaceutica Sinica B |
| spelling | doaj.art-825d7650251d4fcca72ee8e8b614e8f92022-12-22T03:19:58ZengElsevierActa Pharmaceutica Sinica B2211-38352211-38432012-06-012328629310.1016/j.apsb.2012.03.005Rapid determination of pesticide residues in Chinese materia medica using QuEChERS sample preparation followed by gas chromatography–mass spectrometryYichen Hu0Li Wan1Jinming Zhang2Fang Yang3Jiliang Cao4Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, ChinaPharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, ChinaPharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, ChinaPharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, ChinaPharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, ChinaPesticide residue analysis plays an important role in the quality control of Chinese materia medica. This paper reports the development and validation of an analytical method for the quantitative determination of the residues of 39 pesticides in 12 different matrices of Chinese materia medica. Sample preparation utilized the QuEChERS method with acetonitrile:1% aqueous acetic acid (9:1, v/v) as extraction solvent followed by sample clean-up by dispersive solid phase extraction using primary secondary amine sorbent and graphitized carbon black. Extracts were then analysed by gas chromatography coupled with electron impact mass spectrometry in the selected ion monitoring mode. Limit of detection (LOD) and limit of quantitation (LOQ) values were in the ranges 0.5–50 ng/g and 1–100 ng/g, respectively. The recoveries of the 39 pesticides were in the range 75–112% with precision (as relative standard deviation, RSD) <15%. The results show that the modified QuEChERS method allows rapid and sensitive analysis of multiple pesticide residues in Chinese materia medica.http://www.sciencedirect.com/science/article/pii/S2211383512000536Chinese materia medicaGas chromatography–mass spectrometryPesticide residuesQuEChERS method |
| spellingShingle | Yichen Hu Li Wan Jinming Zhang Fang Yang Jiliang Cao Rapid determination of pesticide residues in Chinese materia medica using QuEChERS sample preparation followed by gas chromatography–mass spectrometry Acta Pharmaceutica Sinica B Chinese materia medica Gas chromatography–mass spectrometry Pesticide residues QuEChERS method |
| title | Rapid determination of pesticide residues in Chinese materia medica using QuEChERS sample preparation followed by gas chromatography–mass spectrometry |
| title_full | Rapid determination of pesticide residues in Chinese materia medica using QuEChERS sample preparation followed by gas chromatography–mass spectrometry |
| title_fullStr | Rapid determination of pesticide residues in Chinese materia medica using QuEChERS sample preparation followed by gas chromatography–mass spectrometry |
| title_full_unstemmed | Rapid determination of pesticide residues in Chinese materia medica using QuEChERS sample preparation followed by gas chromatography–mass spectrometry |
| title_short | Rapid determination of pesticide residues in Chinese materia medica using QuEChERS sample preparation followed by gas chromatography–mass spectrometry |
| title_sort | rapid determination of pesticide residues in chinese materia medica using quechers sample preparation followed by gas chromatography mass spectrometry |
| topic | Chinese materia medica Gas chromatography–mass spectrometry Pesticide residues QuEChERS method |
| url | http://www.sciencedirect.com/science/article/pii/S2211383512000536 |
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