Chinese herbal medicine and active ingredients for diabetic cardiomyopathy: molecular mechanisms regulating endoplasmic reticulum stress
Abstract Background: Diabetic cardiomyopathy (DCM) is one of the serious microvascular complications of diabetes mellitus. It is often associated with clinical manifestations such as arrhythmias and heart failure, and significantly reduces the quality of life and years of survival of patients. Endop...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1290023/full |
| _version_ | 1797634972954132480 |
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| author | Lianjun Ao Zhengtao Chen Jiacheng Yin Yulin Leng Yue Luo Xiaoxu Fu Xiaoxu Fu Xiaoxu Fu Hanyu Liu Xiaoke Liu Xiaoke Liu Hong Gao Hong Gao Hong Gao Chunguang Xie Chunguang Xie Chunguang Xie |
| author_facet | Lianjun Ao Zhengtao Chen Jiacheng Yin Yulin Leng Yue Luo Xiaoxu Fu Xiaoxu Fu Xiaoxu Fu Hanyu Liu Xiaoke Liu Xiaoke Liu Hong Gao Hong Gao Hong Gao Chunguang Xie Chunguang Xie Chunguang Xie |
| author_sort | Lianjun Ao |
| collection | DOAJ |
| description | Abstract Background: Diabetic cardiomyopathy (DCM) is one of the serious microvascular complications of diabetes mellitus. It is often associated with clinical manifestations such as arrhythmias and heart failure, and significantly reduces the quality of life and years of survival of patients. Endoplasmic reticulum stress (ERS) is the removal of unfolded and misfolded proteins and is an important mechanism for the maintenance of cellular homeostasis. ERS plays an important role in the pathogenesis of DCM by causing cardiomyocyte apoptosis, insulin resistance, calcium imbalance, myocardial hypertrophy and fibrosis. Targeting ERS is a new direction in the treatment of DCM. A large number of studies have shown that Chinese herbal medicine and active ingredients can significantly improve the clinical outcome of DCM patients through intervention in ERS and effects on myocardial structure and function, which has become one of the hot research directions.Purpose: The aim of this review is to elucidate and summarize the roles and mechanisms of Chinese herbal medicine and active ingredients that have the potential to modulate endoplasmic reticulum stress, thereby contributing to better management of DCM.Methods: Databases such as PubMed, Web of Science, China National Knowledge Internet, and Wanfang Data Knowledge Service Platform were used to search, analyze, and collect literature, in order to review the mechanisms by which phytochemicals inhibit the progression of DCM by targeting the ERS and its key signaling pathways. Keywords used included “diabetic cardiomyopathy” and “endoplasmic reticulum stress.”Results: This review found that Chinese herbs and their active ingredients can regulate ERS through IRE1, ATF6, and PERK pathways to reduce cardiomyocyte apoptosis, ameliorate myocardial fibrosis, and attenuate myocardial hypertrophy for the treatment of DCM.Conclusion: A comprehensive source of information on potential ERS inhibitors is provided in this review. The analysis of the literature suggests that Chinese herbal medicine and its active ingredients can be used as potential drug candidates for the treatment of DCM. In short, we cannot ignore the role of traditional Chinese medicine in regulating ERS and treating DCM, and look forward to more research and new drugs to come. |
| first_indexed | 2024-03-11T12:15:49Z |
| format | Article |
| id | doaj.art-825da323534548348a7d89818a6e4126 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-03-11T12:15:49Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-825da323534548348a7d89818a6e41262023-11-07T09:54:10ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122023-11-011410.3389/fphar.2023.12900231290023Chinese herbal medicine and active ingredients for diabetic cardiomyopathy: molecular mechanisms regulating endoplasmic reticulum stressLianjun Ao0Zhengtao Chen1Jiacheng Yin2Yulin Leng3Yue Luo4Xiaoxu Fu5Xiaoxu Fu6Xiaoxu Fu7Hanyu Liu8Xiaoke Liu9Xiaoke Liu10Hong Gao11Hong Gao12Hong Gao13Chunguang Xie14Chunguang Xie15Chunguang Xie16Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, ChinaAffiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, ChinaHospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, ChinaHospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, ChinaHospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, ChinaHospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, ChinaTCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Chengdu, Sichuan, ChinaDepartment of Endocrinology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaHospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, ChinaHospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, ChinaDepartment of Endocrinology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaHospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, ChinaTCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Chengdu, Sichuan, ChinaDepartment of Endocrinology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaHospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, ChinaTCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Chengdu, Sichuan, ChinaDepartment of Endocrinology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaAbstract Background: Diabetic cardiomyopathy (DCM) is one of the serious microvascular complications of diabetes mellitus. It is often associated with clinical manifestations such as arrhythmias and heart failure, and significantly reduces the quality of life and years of survival of patients. Endoplasmic reticulum stress (ERS) is the removal of unfolded and misfolded proteins and is an important mechanism for the maintenance of cellular homeostasis. ERS plays an important role in the pathogenesis of DCM by causing cardiomyocyte apoptosis, insulin resistance, calcium imbalance, myocardial hypertrophy and fibrosis. Targeting ERS is a new direction in the treatment of DCM. A large number of studies have shown that Chinese herbal medicine and active ingredients can significantly improve the clinical outcome of DCM patients through intervention in ERS and effects on myocardial structure and function, which has become one of the hot research directions.Purpose: The aim of this review is to elucidate and summarize the roles and mechanisms of Chinese herbal medicine and active ingredients that have the potential to modulate endoplasmic reticulum stress, thereby contributing to better management of DCM.Methods: Databases such as PubMed, Web of Science, China National Knowledge Internet, and Wanfang Data Knowledge Service Platform were used to search, analyze, and collect literature, in order to review the mechanisms by which phytochemicals inhibit the progression of DCM by targeting the ERS and its key signaling pathways. Keywords used included “diabetic cardiomyopathy” and “endoplasmic reticulum stress.”Results: This review found that Chinese herbs and their active ingredients can regulate ERS through IRE1, ATF6, and PERK pathways to reduce cardiomyocyte apoptosis, ameliorate myocardial fibrosis, and attenuate myocardial hypertrophy for the treatment of DCM.Conclusion: A comprehensive source of information on potential ERS inhibitors is provided in this review. The analysis of the literature suggests that Chinese herbal medicine and its active ingredients can be used as potential drug candidates for the treatment of DCM. In short, we cannot ignore the role of traditional Chinese medicine in regulating ERS and treating DCM, and look forward to more research and new drugs to come.https://www.frontiersin.org/articles/10.3389/fphar.2023.1290023/fulldiabetic cardiomyopathyendoplasmic reticulum stressChinese herbal medicineactive ingredientsmechanism of action |
| spellingShingle | Lianjun Ao Zhengtao Chen Jiacheng Yin Yulin Leng Yue Luo Xiaoxu Fu Xiaoxu Fu Xiaoxu Fu Hanyu Liu Xiaoke Liu Xiaoke Liu Hong Gao Hong Gao Hong Gao Chunguang Xie Chunguang Xie Chunguang Xie Chinese herbal medicine and active ingredients for diabetic cardiomyopathy: molecular mechanisms regulating endoplasmic reticulum stress Frontiers in Pharmacology diabetic cardiomyopathy endoplasmic reticulum stress Chinese herbal medicine active ingredients mechanism of action |
| title | Chinese herbal medicine and active ingredients for diabetic cardiomyopathy: molecular mechanisms regulating endoplasmic reticulum stress |
| title_full | Chinese herbal medicine and active ingredients for diabetic cardiomyopathy: molecular mechanisms regulating endoplasmic reticulum stress |
| title_fullStr | Chinese herbal medicine and active ingredients for diabetic cardiomyopathy: molecular mechanisms regulating endoplasmic reticulum stress |
| title_full_unstemmed | Chinese herbal medicine and active ingredients for diabetic cardiomyopathy: molecular mechanisms regulating endoplasmic reticulum stress |
| title_short | Chinese herbal medicine and active ingredients for diabetic cardiomyopathy: molecular mechanisms regulating endoplasmic reticulum stress |
| title_sort | chinese herbal medicine and active ingredients for diabetic cardiomyopathy molecular mechanisms regulating endoplasmic reticulum stress |
| topic | diabetic cardiomyopathy endoplasmic reticulum stress Chinese herbal medicine active ingredients mechanism of action |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1290023/full |
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