Folate homeostasis of cancer cells affects sensitivity to not only antifolates but also other non-folate drugs: effect of MRP expression

Folate homeostasis of cancer cells affects sensitivity to not only antifolates but also other non-folate drugs: effect of MRP expression

Sensitivity to antifolates can be decreased by endogenous or exogenous folates. Leucovorin protects cancer patients against toxicity of the dihydrofolate reductase inhibitor methotrexate (MTX), while folic acid is used to protect rheumatoid arthritis patients against MTX. Folates and antifolates can...

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Bibliographic Details
Main Authors: Peters Godefridus J., Kathmann Ietje, Lemos Clara, Hooijberg Jan Hendrik, Losekoot Nienke, Jansen Gerrit
Format: Article
Language:English
Published: De Gruyter 2013-06-01
Series:Pteridines
Subjects:
abcc1
anthracyclines
folate
leucovorin
methotrexate
mrp1
multidrug resistance
Online Access:https://doi.org/10.1515/pterid-2013-0019

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