Melatonin and Mesenchymal Stem Cells as a Key for Functional Integrity for Liver Cancer Treatment
Hepatocellular carcinoma (HCC) is the most common hepatobiliary malignancy with limited therapeutic options. On the other hand, melatonin is an indoleamine that modulates a variety of potential therapeutic effects. In addition to its important role in the regulation of sleep–wake rhythms, several pr...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-06-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/21/12/4521 |
| _version_ | 1797564158047158272 |
|---|---|
| author | Ehab Kotb Elmahallawy Yasser Mohamed Walied Abdo Tokuma Yanai |
| author_facet | Ehab Kotb Elmahallawy Yasser Mohamed Walied Abdo Tokuma Yanai |
| author_sort | Ehab Kotb Elmahallawy |
| collection | DOAJ |
| description | Hepatocellular carcinoma (HCC) is the most common hepatobiliary malignancy with limited therapeutic options. On the other hand, melatonin is an indoleamine that modulates a variety of potential therapeutic effects. In addition to its important role in the regulation of sleep–wake rhythms, several previous studies linked the biologic effects of melatonin to various substantial endocrine, neural, immune and antioxidant functions, among others. Furthermore, the effects of melatonin could be influenced through receptor dependent and receptor independent manner. Among the other numerous physiological and therapeutic effects of melatonin, controlling the survival and differentiation of mesenchymal stem cells (MSCs) has been recently discussed. Given its controversial interaction, several previous reports revealed the therapeutic potential of MSCs in controlling the hepatocellular carcinoma (HCC). Taken together, the intention of the present review is to highlight the effects of melatonin and mesenchymal stem cells as a key for functional integrity for liver cancer treatment. We hope to provide solid piece of information that may be helpful in designing novel drug targets to control HCC. |
| first_indexed | 2024-03-10T18:53:22Z |
| format | Article |
| id | doaj.art-825e6b2fc0f24d158995ca25b1a32113 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T18:53:22Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-825e6b2fc0f24d158995ca25b1a321132023-11-20T04:57:45ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-06-012112452110.3390/ijms21124521Melatonin and Mesenchymal Stem Cells as a Key for Functional Integrity for Liver Cancer TreatmentEhab Kotb Elmahallawy0Yasser Mohamed1Walied Abdo2Tokuma Yanai3Department for Management of Science and Technology Development, Ton Duc Thang University, Ho Chi Minh, VietnamLaboratory of Kafr El Sheikh Fever Hospital, Kafr El Sheikh Fever Hospital, 33511 Kafr El-Sheikh, EgyptDepartment of Pathology, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafr El Sheikh Governorate 33516, EgyptLaboratory of Wildlife and Forensic Pathology/Biomedical Science Examination and Research Center, Department of Veterinary Medicine, Faculty of Veterinary Medicine, Okayama University of Science, Okayama 700-8530, JapanHepatocellular carcinoma (HCC) is the most common hepatobiliary malignancy with limited therapeutic options. On the other hand, melatonin is an indoleamine that modulates a variety of potential therapeutic effects. In addition to its important role in the regulation of sleep–wake rhythms, several previous studies linked the biologic effects of melatonin to various substantial endocrine, neural, immune and antioxidant functions, among others. Furthermore, the effects of melatonin could be influenced through receptor dependent and receptor independent manner. Among the other numerous physiological and therapeutic effects of melatonin, controlling the survival and differentiation of mesenchymal stem cells (MSCs) has been recently discussed. Given its controversial interaction, several previous reports revealed the therapeutic potential of MSCs in controlling the hepatocellular carcinoma (HCC). Taken together, the intention of the present review is to highlight the effects of melatonin and mesenchymal stem cells as a key for functional integrity for liver cancer treatment. We hope to provide solid piece of information that may be helpful in designing novel drug targets to control HCC.https://www.mdpi.com/1422-0067/21/12/4521melatoninmesenchymal stem cellsliver cancerfunctional integrity |
| spellingShingle | Ehab Kotb Elmahallawy Yasser Mohamed Walied Abdo Tokuma Yanai Melatonin and Mesenchymal Stem Cells as a Key for Functional Integrity for Liver Cancer Treatment International Journal of Molecular Sciences melatonin mesenchymal stem cells liver cancer functional integrity |
| title | Melatonin and Mesenchymal Stem Cells as a Key for Functional Integrity for Liver Cancer Treatment |
| title_full | Melatonin and Mesenchymal Stem Cells as a Key for Functional Integrity for Liver Cancer Treatment |
| title_fullStr | Melatonin and Mesenchymal Stem Cells as a Key for Functional Integrity for Liver Cancer Treatment |
| title_full_unstemmed | Melatonin and Mesenchymal Stem Cells as a Key for Functional Integrity for Liver Cancer Treatment |
| title_short | Melatonin and Mesenchymal Stem Cells as a Key for Functional Integrity for Liver Cancer Treatment |
| title_sort | melatonin and mesenchymal stem cells as a key for functional integrity for liver cancer treatment |
| topic | melatonin mesenchymal stem cells liver cancer functional integrity |
| url | https://www.mdpi.com/1422-0067/21/12/4521 |
| work_keys_str_mv | AT ehabkotbelmahallawy melatoninandmesenchymalstemcellsasakeyforfunctionalintegrityforlivercancertreatment AT yassermohamed melatoninandmesenchymalstemcellsasakeyforfunctionalintegrityforlivercancertreatment AT waliedabdo melatoninandmesenchymalstemcellsasakeyforfunctionalintegrityforlivercancertreatment AT tokumayanai melatoninandmesenchymalstemcellsasakeyforfunctionalintegrityforlivercancertreatment |