Antibacterial and antifungal activities of Schiff base and its metal (Ii) complexes of Fe (Ii), Ni (Ii) and Co (Ii) derived from 2-hydroxy-1-naphthaldehyde and 2-amino-3-methylpyridine.
Aim and methods: The Schiff base was synthesized by condensation of 2-hydroxy-1-naphthaldehyde with 2-amino-3-methylpyridine and its complexes of Fe (II), Ni (II) and Co (II) chlorides were synthesized and characterized by melting point, solubility test, conductivity, measurement, magnetic susceptib...
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| Format: | Article |
| Language: | English |
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Zagazig University, Faculty of Medicine
2023-02-01
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| Series: | Microbes and Infectious Diseases |
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| Online Access: | https://mid.journals.ekb.eg/article_222750_c192efd58169e4f9a5cfd5139065602f.pdf |
| _version_ | 1797937111861559296 |
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| author | Bala Uba |
| author_facet | Bala Uba |
| author_sort | Bala Uba |
| collection | DOAJ |
| description | Aim and methods: The Schiff base was synthesized by condensation of 2-hydroxy-1-naphthaldehyde with 2-amino-3-methylpyridine and its complexes of Fe (II), Ni (II) and Co (II) chlorides were synthesized and characterized by melting point, solubility test, conductivity, measurement, magnetic susceptibility measurement and infrared (IR) spectroscopy. The Schiff base and its respective metal complexes were colored with sharp melting point and are soluble in ethanol, dimethylsulfuroxide and methanol but insoluble in water and slightly soluble in other solvent. The conductivity value obtained indicates that the synthesized complexes are non-electrolytes while an octahedral geometry was suggested for all complexes based on the data obtained from magnetic susceptibility analysis. Results: The IR results revealed bands at 1596cm-1 indicating the formation of azomethine (C=N) confirming the formation of Schiff base. 791cm-1, 683cm-1, 747cm-1 for (M-N) and 447cm-1, 461cm-1, 451cm-1 for (M-O) bands in the spectra of the complexes supporting coordination of Schiff base to respective metals. Conclusion: The in vitro antimicrobial screening of Schiff base and its metal complexes against Staphylococcus aureus, Escherichia coli, Streptococcus pneumonia, Klebsiella pneumonia, Aspergillus niger and Candida albicans showed that they are potential antibacterial and antifungal agents against the tested microorganisms. |
| first_indexed | 2024-04-10T18:39:39Z |
| format | Article |
| id | doaj.art-825e6ca3136a4c74bd3779e2fd1c4035 |
| institution | Directory Open Access Journal |
| issn | 2682-4132 2682-4140 |
| language | English |
| last_indexed | 2024-04-10T18:39:39Z |
| publishDate | 2023-02-01 |
| publisher | Zagazig University, Faculty of Medicine |
| record_format | Article |
| series | Microbes and Infectious Diseases |
| spelling | doaj.art-825e6ca3136a4c74bd3779e2fd1c40352023-02-01T17:44:13ZengZagazig University, Faculty of MedicineMicrobes and Infectious Diseases2682-41322682-41402023-02-014131232210.21608/mid.2022.118030.1240222750Antibacterial and antifungal activities of Schiff base and its metal (Ii) complexes of Fe (Ii), Ni (Ii) and Co (Ii) derived from 2-hydroxy-1-naphthaldehyde and 2-amino-3-methylpyridine.Bala Uba0Chemistry Department Yobe State University Damaturu NigeriaAim and methods: The Schiff base was synthesized by condensation of 2-hydroxy-1-naphthaldehyde with 2-amino-3-methylpyridine and its complexes of Fe (II), Ni (II) and Co (II) chlorides were synthesized and characterized by melting point, solubility test, conductivity, measurement, magnetic susceptibility measurement and infrared (IR) spectroscopy. The Schiff base and its respective metal complexes were colored with sharp melting point and are soluble in ethanol, dimethylsulfuroxide and methanol but insoluble in water and slightly soluble in other solvent. The conductivity value obtained indicates that the synthesized complexes are non-electrolytes while an octahedral geometry was suggested for all complexes based on the data obtained from magnetic susceptibility analysis. Results: The IR results revealed bands at 1596cm-1 indicating the formation of azomethine (C=N) confirming the formation of Schiff base. 791cm-1, 683cm-1, 747cm-1 for (M-N) and 447cm-1, 461cm-1, 451cm-1 for (M-O) bands in the spectra of the complexes supporting coordination of Schiff base to respective metals. Conclusion: The in vitro antimicrobial screening of Schiff base and its metal complexes against Staphylococcus aureus, Escherichia coli, Streptococcus pneumonia, Klebsiella pneumonia, Aspergillus niger and Candida albicans showed that they are potential antibacterial and antifungal agents against the tested microorganisms.https://mid.journals.ekb.eg/article_222750_c192efd58169e4f9a5cfd5139065602f.pdfkey word: synthesis2-amino-3-methylpyridineantibacterialantifungalactivities |
| spellingShingle | Bala Uba Antibacterial and antifungal activities of Schiff base and its metal (Ii) complexes of Fe (Ii), Ni (Ii) and Co (Ii) derived from 2-hydroxy-1-naphthaldehyde and 2-amino-3-methylpyridine. Microbes and Infectious Diseases key word: synthesis 2-amino-3-methylpyridine antibacterial antifungal activities |
| title | Antibacterial and antifungal activities of Schiff base and its metal (Ii) complexes of Fe (Ii), Ni (Ii) and Co (Ii) derived from 2-hydroxy-1-naphthaldehyde and 2-amino-3-methylpyridine. |
| title_full | Antibacterial and antifungal activities of Schiff base and its metal (Ii) complexes of Fe (Ii), Ni (Ii) and Co (Ii) derived from 2-hydroxy-1-naphthaldehyde and 2-amino-3-methylpyridine. |
| title_fullStr | Antibacterial and antifungal activities of Schiff base and its metal (Ii) complexes of Fe (Ii), Ni (Ii) and Co (Ii) derived from 2-hydroxy-1-naphthaldehyde and 2-amino-3-methylpyridine. |
| title_full_unstemmed | Antibacterial and antifungal activities of Schiff base and its metal (Ii) complexes of Fe (Ii), Ni (Ii) and Co (Ii) derived from 2-hydroxy-1-naphthaldehyde and 2-amino-3-methylpyridine. |
| title_short | Antibacterial and antifungal activities of Schiff base and its metal (Ii) complexes of Fe (Ii), Ni (Ii) and Co (Ii) derived from 2-hydroxy-1-naphthaldehyde and 2-amino-3-methylpyridine. |
| title_sort | antibacterial and antifungal activities of schiff base and its metal ii complexes of fe ii ni ii and co ii derived from 2 hydroxy 1 naphthaldehyde and 2 amino 3 methylpyridine |
| topic | key word: synthesis 2-amino-3-methylpyridine antibacterial antifungal activities |
| url | https://mid.journals.ekb.eg/article_222750_c192efd58169e4f9a5cfd5139065602f.pdf |
| work_keys_str_mv | AT balauba antibacterialandantifungalactivitiesofschiffbaseanditsmetaliicomplexesoffeiiniiiandcoiiderivedfrom2hydroxy1naphthaldehydeand2amino3methylpyridine |