Monitoring the Aggregation of Amyloid-β in the Presence of Polyphenols with Emphasis on Curcumin
The aggregation of amyloid-β (Aβ) into fibrils forms the plaques implicated in the pathology of Alzheimer’s disease, an aggressive cognitive disorder that impairs function of the cerebral cortex. Therefore, discovery of a mechanism by which fibril disaggregation occurs is of vital importance to the...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Appalachian State University Honors College
2022-08-01
|
| Series: | Impulse: The Premier Undergraduate Neuroscience Journal |
| Subjects: | |
| Online Access: | https://impulse.pubpub.org/pub/gzlbek6g/release/1 |
| _version_ | 1828433998171340800 |
|---|---|
| author | Valerie Winkler Brittany Hagenhoff |
| author_facet | Valerie Winkler Brittany Hagenhoff |
| author_sort | Valerie Winkler |
| collection | DOAJ |
| description | The aggregation of amyloid-β (Aβ) into fibrils forms the plaques implicated in the pathology of Alzheimer’s disease, an aggressive cognitive disorder that impairs function of the cerebral cortex. Therefore, discovery of a mechanism by which fibril disaggregation occurs is of vital importance to the medical community. Here, the current knowledge of and methods to measure Aβ aggregation are reviewed, specifically focusing on the formulation of fluorescence assays as well as a review of the use of polyphenolic compounds as disaggregation agents. One such polyphenol is curcumin, a curcuminoid derived from Curcuma longa that has seen some effective results for reducing Aβ aggregation; however, potential intermolecular interaction complications should be considered in analysis, especially in the popular emission assay studies with Thioflavin T as a fluorescent probe. Overall, future work to determine the applicability of curcumin, as well as other polyphenols, on the prevention or disassembly of Aβ fibrils must account for intermolecular interactions by experiment and the employment of computational means to ascertain an accurate degree of potential therapeutic effect. |
| first_indexed | 2024-12-10T18:43:56Z |
| format | Article |
| id | doaj.art-825e8caf2c004f0f8edbc05380af2cee |
| institution | Directory Open Access Journal |
| issn | 1934-3361 |
| language | English |
| last_indexed | 2024-12-10T18:43:56Z |
| publishDate | 2022-08-01 |
| publisher | Appalachian State University Honors College |
| record_format | Article |
| series | Impulse: The Premier Undergraduate Neuroscience Journal |
| spelling | doaj.art-825e8caf2c004f0f8edbc05380af2cee2022-12-22T01:37:34ZengAppalachian State University Honors CollegeImpulse: The Premier Undergraduate Neuroscience Journal1934-33612022-08-01Monitoring the Aggregation of Amyloid-β in the Presence of Polyphenols with Emphasis on CurcuminValerie Winkler0Brittany Hagenhoff1Truman State UniversityTruman State UniversityThe aggregation of amyloid-β (Aβ) into fibrils forms the plaques implicated in the pathology of Alzheimer’s disease, an aggressive cognitive disorder that impairs function of the cerebral cortex. Therefore, discovery of a mechanism by which fibril disaggregation occurs is of vital importance to the medical community. Here, the current knowledge of and methods to measure Aβ aggregation are reviewed, specifically focusing on the formulation of fluorescence assays as well as a review of the use of polyphenolic compounds as disaggregation agents. One such polyphenol is curcumin, a curcuminoid derived from Curcuma longa that has seen some effective results for reducing Aβ aggregation; however, potential intermolecular interaction complications should be considered in analysis, especially in the popular emission assay studies with Thioflavin T as a fluorescent probe. Overall, future work to determine the applicability of curcumin, as well as other polyphenols, on the prevention or disassembly of Aβ fibrils must account for intermolecular interactions by experiment and the employment of computational means to ascertain an accurate degree of potential therapeutic effect.https://impulse.pubpub.org/pub/gzlbek6g/release/1amyloid-βalzheimer'scurcuminpolyphenolthioflavin tfluorescence |
| spellingShingle | Valerie Winkler Brittany Hagenhoff Monitoring the Aggregation of Amyloid-β in the Presence of Polyphenols with Emphasis on Curcumin Impulse: The Premier Undergraduate Neuroscience Journal amyloid-β alzheimer's curcumin polyphenol thioflavin t fluorescence |
| title | Monitoring the Aggregation of Amyloid-β in the Presence of Polyphenols with Emphasis on Curcumin |
| title_full | Monitoring the Aggregation of Amyloid-β in the Presence of Polyphenols with Emphasis on Curcumin |
| title_fullStr | Monitoring the Aggregation of Amyloid-β in the Presence of Polyphenols with Emphasis on Curcumin |
| title_full_unstemmed | Monitoring the Aggregation of Amyloid-β in the Presence of Polyphenols with Emphasis on Curcumin |
| title_short | Monitoring the Aggregation of Amyloid-β in the Presence of Polyphenols with Emphasis on Curcumin |
| title_sort | monitoring the aggregation of amyloid β in the presence of polyphenols with emphasis on curcumin |
| topic | amyloid-β alzheimer's curcumin polyphenol thioflavin t fluorescence |
| url | https://impulse.pubpub.org/pub/gzlbek6g/release/1 |
| work_keys_str_mv | AT valeriewinkler monitoringtheaggregationofamyloidbinthepresenceofpolyphenolswithemphasisoncurcumin AT brittanyhagenhoff monitoringtheaggregationofamyloidbinthepresenceofpolyphenolswithemphasisoncurcumin |