Determinants of informal care time, distress, depression, and quality of life in care partners along the trajectory of Alzheimer's disease
Abstract Introduction We evaluated determinants associated with care partner outcomes along the Alzheimer's disease (AD) stages. Methods We included n = 270 care partners of amyloid‐positive patients in the pre‐dementia and dementia stages of AD. Using linear regression analysis, we examined de...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-04-01
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| Series: | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/dad2.12418 |
| _version_ | 1827353803791269888 |
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| author | Arenda Mank Ingrid S. vanMaurik Judith J. M. Rijnhart Hanneke F. M. Rhodius‐Meester Leonie N. C. Visser Afina W. Lemstra Sietske A. M. Sikkes Charlotte E. Teunissen Elsmarieke M. vanGiessen Johannes Berkhof Wiesje M. van derFlier |
| author_facet | Arenda Mank Ingrid S. vanMaurik Judith J. M. Rijnhart Hanneke F. M. Rhodius‐Meester Leonie N. C. Visser Afina W. Lemstra Sietske A. M. Sikkes Charlotte E. Teunissen Elsmarieke M. vanGiessen Johannes Berkhof Wiesje M. van derFlier |
| author_sort | Arenda Mank |
| collection | DOAJ |
| description | Abstract Introduction We evaluated determinants associated with care partner outcomes along the Alzheimer's disease (AD) stages. Methods We included n = 270 care partners of amyloid‐positive patients in the pre‐dementia and dementia stages of AD. Using linear regression analysis, we examined determinants of four care partner outcomes: informal care time, caregiver distress, depression, and quality of life (QoL). Results More behavioral symptoms and functional impairment in patients were associated with more informal care time and depressive symptoms in care partners. More behavioral symptoms were related with more caregiver distress. Spouse care partners spent more time on informal care and QoL was lower in female care partners. Behavioral problems and subtle functional impairment of the patient predisposed for worse care partner outcomes already in the pre‐dementia stages. Discussion Both patient and care partner determinants contribute to the care partner outcomes, already in early disease stages. This study provides red flags for high care partner burden. |
| first_indexed | 2024-03-08T03:33:19Z |
| format | Article |
| id | doaj.art-8261577cecd441f69255b0cca56a156c |
| institution | Directory Open Access Journal |
| issn | 2352-8729 |
| language | English |
| last_indexed | 2024-03-08T03:33:19Z |
| publishDate | 2023-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
| spelling | doaj.art-8261577cecd441f69255b0cca56a156c2024-02-10T14:10:32ZengWileyAlzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring2352-87292023-04-01152n/an/a10.1002/dad2.12418Determinants of informal care time, distress, depression, and quality of life in care partners along the trajectory of Alzheimer's diseaseArenda Mank0Ingrid S. vanMaurik1Judith J. M. Rijnhart2Hanneke F. M. Rhodius‐Meester3Leonie N. C. Visser4Afina W. Lemstra5Sietske A. M. Sikkes6Charlotte E. Teunissen7Elsmarieke M. vanGiessen8Johannes Berkhof9Wiesje M. van derFlier10Alzheimer Center Amsterdam, Department of Neurology Vrije Universiteit Amsterdam Amsterdam UMC VUmc Amsterdam the NetherlandsAlzheimer Center Amsterdam, Department of Neurology Vrije Universiteit Amsterdam Amsterdam UMC VUmc Amsterdam the NetherlandsCollege of Public Health University of South Florida Tampa Florida USAAlzheimer Center Amsterdam, Department of Neurology Vrije Universiteit Amsterdam Amsterdam UMC VUmc Amsterdam the NetherlandsDepartment of Medical Psychology Amsterdam UMC, AMC University of Amsterdam Amsterdam the NetherlandsAlzheimer Center Amsterdam, Department of Neurology Vrije Universiteit Amsterdam Amsterdam UMC VUmc Amsterdam the NetherlandsAlzheimer Center Amsterdam, Department of Neurology Vrije Universiteit Amsterdam Amsterdam UMC VUmc Amsterdam the NetherlandsAmsterdam Neuroscience Neurodegeneration Amsterdam the NetherlandsDepartment of Radiology & Nuclear Medicine Vrije Universiteit Amsterdam Amsterdam UMC, VUmc Amsterdam the NetherlandsAmsterdam UMC Vrije Universiteit Amsterdam Department of Epidemiology and Data Science Amsterdam Public Health Institute Amsterdam the NetherlandsAlzheimer Center Amsterdam, Department of Neurology Vrije Universiteit Amsterdam Amsterdam UMC VUmc Amsterdam the NetherlandsAbstract Introduction We evaluated determinants associated with care partner outcomes along the Alzheimer's disease (AD) stages. Methods We included n = 270 care partners of amyloid‐positive patients in the pre‐dementia and dementia stages of AD. Using linear regression analysis, we examined determinants of four care partner outcomes: informal care time, caregiver distress, depression, and quality of life (QoL). Results More behavioral symptoms and functional impairment in patients were associated with more informal care time and depressive symptoms in care partners. More behavioral symptoms were related with more caregiver distress. Spouse care partners spent more time on informal care and QoL was lower in female care partners. Behavioral problems and subtle functional impairment of the patient predisposed for worse care partner outcomes already in the pre‐dementia stages. Discussion Both patient and care partner determinants contribute to the care partner outcomes, already in early disease stages. This study provides red flags for high care partner burden.https://doi.org/10.1002/dad2.12418Alzheimer's diseasecaregiverdementiadepressioninformal care timemild cognitive impairment |
| spellingShingle | Arenda Mank Ingrid S. vanMaurik Judith J. M. Rijnhart Hanneke F. M. Rhodius‐Meester Leonie N. C. Visser Afina W. Lemstra Sietske A. M. Sikkes Charlotte E. Teunissen Elsmarieke M. vanGiessen Johannes Berkhof Wiesje M. van derFlier Determinants of informal care time, distress, depression, and quality of life in care partners along the trajectory of Alzheimer's disease Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring Alzheimer's disease caregiver dementia depression informal care time mild cognitive impairment |
| title | Determinants of informal care time, distress, depression, and quality of life in care partners along the trajectory of Alzheimer's disease |
| title_full | Determinants of informal care time, distress, depression, and quality of life in care partners along the trajectory of Alzheimer's disease |
| title_fullStr | Determinants of informal care time, distress, depression, and quality of life in care partners along the trajectory of Alzheimer's disease |
| title_full_unstemmed | Determinants of informal care time, distress, depression, and quality of life in care partners along the trajectory of Alzheimer's disease |
| title_short | Determinants of informal care time, distress, depression, and quality of life in care partners along the trajectory of Alzheimer's disease |
| title_sort | determinants of informal care time distress depression and quality of life in care partners along the trajectory of alzheimer s disease |
| topic | Alzheimer's disease caregiver dementia depression informal care time mild cognitive impairment |
| url | https://doi.org/10.1002/dad2.12418 |
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