Novel applications of trophic factors, Wnt and WISP for neuronal repair and regeneration in metabolic disease
Diabetes mellitus affects almost 350 million individuals throughout the globe resulting in significant morbidity and mortality. Of further concern is the growing population of individuals that remain undiagnosed but are susceptible to the detrimental outcomes of this disorder. Diabetes mellitus lead...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2015-01-01
|
| Series: | Neural Regeneration Research |
| Subjects: | |
| Online Access: | http://www.nrronline.org/article.asp?issn=1673-5374;year=2015;volume=10;issue=4;spage=518;epage=528;aulast=Maiese |
| _version_ | 1818884425310535680 |
|---|---|
| author | Kenneth Maiese |
| author_facet | Kenneth Maiese |
| author_sort | Kenneth Maiese |
| collection | DOAJ |
| description | Diabetes mellitus affects almost 350 million individuals throughout the globe resulting in significant morbidity and mortality. Of further concern is the growing population of individuals that remain undiagnosed but are susceptible to the detrimental outcomes of this disorder. Diabetes mellitus leads to multiple complications in the central and peripheral nervous systems that include cognitive impairment, retinal disease, neuropsychiatric disease, cerebral ischemia, and peripheral nerve degeneration. Although multiple strategies are being considered, novel targeting of trophic factors, Wnt signaling, Wnt1 inducible signaling pathway protein 1, and stem cell tissue regeneration are considered to be exciting prospects to overcome the cellular mechanisms that lead to neuronal injury in diabetes mellitus involving oxidative stress, apoptosis, and autophagy. Pathways that involve insulin-like growth factor-1, fibroblast growth factor, epidermal growth factor, and erythropoietin can govern glucose homeostasis and are intimately tied to Wnt signaling that involves Wnt1 and Wnt1 inducible signaling pathway protein 1 (CCN4) to foster control over stem cell proliferation, wound repair, cognitive decline,β-cell proliferation, vascular regeneration, and programmed cell death. Ultimately, cellular metabolism through Wnt signaling is driven by primary metabolic pathways of the mechanistic target of rapamycin and AMP activated protein kinase. These pathways offer precise biological control of cellular metabolism, but are exquisitely sensitive to the different components of Wnt signaling. As a result, unexpected clinical outcomes can ensue and therefore demand careful translation of the mechanisms that govern neural repair and regeneration in diabetes mellitus. |
| first_indexed | 2024-12-19T15:49:20Z |
| format | Article |
| id | doaj.art-826682dda0a444bca0dca0eab365fcaa |
| institution | Directory Open Access Journal |
| issn | 1673-5374 |
| language | English |
| last_indexed | 2024-12-19T15:49:20Z |
| publishDate | 2015-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neural Regeneration Research |
| spelling | doaj.art-826682dda0a444bca0dca0eab365fcaa2022-12-21T20:15:15ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742015-01-0110451852810.4103/1673-5374.155427Novel applications of trophic factors, Wnt and WISP for neuronal repair and regeneration in metabolic diseaseKenneth MaieseDiabetes mellitus affects almost 350 million individuals throughout the globe resulting in significant morbidity and mortality. Of further concern is the growing population of individuals that remain undiagnosed but are susceptible to the detrimental outcomes of this disorder. Diabetes mellitus leads to multiple complications in the central and peripheral nervous systems that include cognitive impairment, retinal disease, neuropsychiatric disease, cerebral ischemia, and peripheral nerve degeneration. Although multiple strategies are being considered, novel targeting of trophic factors, Wnt signaling, Wnt1 inducible signaling pathway protein 1, and stem cell tissue regeneration are considered to be exciting prospects to overcome the cellular mechanisms that lead to neuronal injury in diabetes mellitus involving oxidative stress, apoptosis, and autophagy. Pathways that involve insulin-like growth factor-1, fibroblast growth factor, epidermal growth factor, and erythropoietin can govern glucose homeostasis and are intimately tied to Wnt signaling that involves Wnt1 and Wnt1 inducible signaling pathway protein 1 (CCN4) to foster control over stem cell proliferation, wound repair, cognitive decline,β-cell proliferation, vascular regeneration, and programmed cell death. Ultimately, cellular metabolism through Wnt signaling is driven by primary metabolic pathways of the mechanistic target of rapamycin and AMP activated protein kinase. These pathways offer precise biological control of cellular metabolism, but are exquisitely sensitive to the different components of Wnt signaling. As a result, unexpected clinical outcomes can ensue and therefore demand careful translation of the mechanisms that govern neural repair and regeneration in diabetes mellitus.http://www.nrronline.org/article.asp?issn=1673-5374;year=2015;volume=10;issue=4;spage=518;epage=528;aulast=Maiesespinal cord injurypropriospinal systemneural plasticityfiber sproutingneural repaircompensationregenerationpropriospinal detoursneurotrophic factorscell-adhesive ligandsdorsal root gangliaL1CAMnerve growth factorbiomaterialselastin-like proteinsAlzheimer′s diseaseAMPKapoptosisautophagycentral nervous systemCCN4EGFdiabetes mellituserythropoietinEPOFGFIGF-1mTORneuronneuropathyoxidative stresspsychiatricstem cellsWISP1Wnt |
| spellingShingle | Kenneth Maiese Novel applications of trophic factors, Wnt and WISP for neuronal repair and regeneration in metabolic disease Neural Regeneration Research spinal cord injury propriospinal system neural plasticity fiber sprouting neural repair compensation regeneration propriospinal detours neurotrophic factors cell-adhesive ligands dorsal root ganglia L1CAM nerve growth factor biomaterials elastin-like proteins Alzheimer′s disease AMPK apoptosis autophagy central nervous system CCN4 EGF diabetes mellitus erythropoietin EPO FGF IGF-1 mTOR neuron neuropathy oxidative stress psychiatric stem cells WISP1 Wnt |
| title | Novel applications of trophic factors, Wnt and WISP for neuronal repair and regeneration in metabolic disease |
| title_full | Novel applications of trophic factors, Wnt and WISP for neuronal repair and regeneration in metabolic disease |
| title_fullStr | Novel applications of trophic factors, Wnt and WISP for neuronal repair and regeneration in metabolic disease |
| title_full_unstemmed | Novel applications of trophic factors, Wnt and WISP for neuronal repair and regeneration in metabolic disease |
| title_short | Novel applications of trophic factors, Wnt and WISP for neuronal repair and regeneration in metabolic disease |
| title_sort | novel applications of trophic factors wnt and wisp for neuronal repair and regeneration in metabolic disease |
| topic | spinal cord injury propriospinal system neural plasticity fiber sprouting neural repair compensation regeneration propriospinal detours neurotrophic factors cell-adhesive ligands dorsal root ganglia L1CAM nerve growth factor biomaterials elastin-like proteins Alzheimer′s disease AMPK apoptosis autophagy central nervous system CCN4 EGF diabetes mellitus erythropoietin EPO FGF IGF-1 mTOR neuron neuropathy oxidative stress psychiatric stem cells WISP1 Wnt |
| url | http://www.nrronline.org/article.asp?issn=1673-5374;year=2015;volume=10;issue=4;spage=518;epage=528;aulast=Maiese |
| work_keys_str_mv | AT kennethmaiese novelapplicationsoftrophicfactorswntandwispforneuronalrepairandregenerationinmetabolicdisease |