The FDA-approved drug nitazoxanide is a potent inhibitor of human seasonal coronaviruses acting at postentry level: effect on the viral spike glycoprotein

The FDA-approved drug nitazoxanide is a potent inhibitor of human seasonal coronaviruses acting at postentry level: effect on the viral spike glycoprotein

Coronaviridae is recognized as one of the most rapidly evolving virus family as a consequence of the high genomic nucleotide substitution rates and recombination. The family comprises a large number of enveloped, positive-sense single-stranded RNA viruses, causing an array of diseases of varying sev...

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Bibliographic Details
Main Authors: Sara Piacentini, Anna Riccio, Silvia Santopolo, Silvia Pauciullo, Simone La Frazia, Antonio Rossi, Jean-Francois Rossignol, M. Gabriella Santoro
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Microbiology
Subjects:
antiviral
HCoV-229E
HCoV-OC43
HCoV-NL63
nitazoxanide
spike glycoprotein
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2023.1206951/full

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