Research progress of microRNA in oxidative stress and lipid metabolism of non-exudative age-related macular degeneration
Age-related macular degeneration(ARMD)is a neurodegenerative disease associated with oxidative stress. It is characterized by progressive death of photoreceptors and retinal pigment epithelium(RPE), and is one of the leading causes of irreversible loss of central vision in patients over the age of 6...
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2024-04-01
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| Series: | Guoji Yanke Zazhi |
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| Online Access: | http://ies.ijo.cn/cn_publish/2024/4/202404012.pdf |
| _version_ | 1797249351691534336 |
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| author | Tian Zhen Zhang Tiantian Li Jing |
| author_facet | Tian Zhen Zhang Tiantian Li Jing |
| author_sort | Tian Zhen |
| collection | DOAJ |
| description | Age-related macular degeneration(ARMD)is a neurodegenerative disease associated with oxidative stress. It is characterized by progressive death of photoreceptors and retinal pigment epithelium(RPE), and is one of the leading causes of irreversible loss of central vision in patients over the age of 65 years old. MicroRNA(miRNA)is a class of regulatory short-chain non-coding RNA that can bind and inhibit multiple gene targets in the same biological pathway. This unique property makes microRNA an ideal target for exploring the pathogenesis, diagnosis and treatment of non-exudative ARMD. Previous studies have found that the pathogenesis of non-exudative ARMD involves age, genetics, environment, oxidative stress, lipid metabolism, autophagy and immunity. However, the exact mechanisms have not been fully clarified. As biomarkers of non-exudative ARMD, miRNA play a role in oxidative stress and lipid metabolism. This article summarizes the role of various miRNA in targeting Nrf2 and HIF-1α to inhibit hypoxia-related angiogenesis signaling, thereby affecting oxidative stress. Additionally, miRNA regulate lipid uptake and the expression of ABCA1 in RPE and macrophages, thereby influencing lipid metabolism. This deepens the understanding of the role of miRNA in oxidative stress and lipid metabolism in non-exudative ARMD, and provides directions for further improving the understanding of the pathogenesis and prevention of non-exudative ARMD. |
| first_indexed | 2024-04-24T20:29:06Z |
| format | Article |
| id | doaj.art-82681b6dd35c4e079f69cd9f519ef0b9 |
| institution | Directory Open Access Journal |
| issn | 1672-5123 |
| language | English |
| last_indexed | 2024-04-24T20:29:06Z |
| publishDate | 2024-04-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | Guoji Yanke Zazhi |
| spelling | doaj.art-82681b6dd35c4e079f69cd9f519ef0b92024-03-22T03:14:27ZengPress of International Journal of Ophthalmology (IJO PRESS)Guoji Yanke Zazhi1672-51232024-04-0124456156610.3980/j.issn.1672-5123.2024.4.12202404012Research progress of microRNA in oxidative stress and lipid metabolism of non-exudative age-related macular degenerationTian Zhen0Zhang Tiantian1Li Jing2Xi'an Medical University, Xi'an 710021, Shaanxi Province, China; Department of Ophthalmology, Shaanxi Provincial People's Hospital, Xi'an 710068, Shaanxi Province, ChinaXi'an Medical University, Xi'an 710021, Shaanxi Province, China; Department of Ophthalmology, Shaanxi Provincial People's Hospital, Xi'an 710068, Shaanxi Province, ChinaDepartment of Ophthalmology, Shaanxi Provincial People's Hospital, Xi'an 710068, Shaanxi Province, ChinaAge-related macular degeneration(ARMD)is a neurodegenerative disease associated with oxidative stress. It is characterized by progressive death of photoreceptors and retinal pigment epithelium(RPE), and is one of the leading causes of irreversible loss of central vision in patients over the age of 65 years old. MicroRNA(miRNA)is a class of regulatory short-chain non-coding RNA that can bind and inhibit multiple gene targets in the same biological pathway. This unique property makes microRNA an ideal target for exploring the pathogenesis, diagnosis and treatment of non-exudative ARMD. Previous studies have found that the pathogenesis of non-exudative ARMD involves age, genetics, environment, oxidative stress, lipid metabolism, autophagy and immunity. However, the exact mechanisms have not been fully clarified. As biomarkers of non-exudative ARMD, miRNA play a role in oxidative stress and lipid metabolism. This article summarizes the role of various miRNA in targeting Nrf2 and HIF-1α to inhibit hypoxia-related angiogenesis signaling, thereby affecting oxidative stress. Additionally, miRNA regulate lipid uptake and the expression of ABCA1 in RPE and macrophages, thereby influencing lipid metabolism. This deepens the understanding of the role of miRNA in oxidative stress and lipid metabolism in non-exudative ARMD, and provides directions for further improving the understanding of the pathogenesis and prevention of non-exudative ARMD.http://ies.ijo.cn/cn_publish/2024/4/202404012.pdfnon-exudative age-related macular degenerationmicrornaoxidative stresslipid metabolismretinal pigment epitheliumnuclear factor erythrocyte 2 related factoratp binding cassette transporter a1 |
| spellingShingle | Tian Zhen Zhang Tiantian Li Jing Research progress of microRNA in oxidative stress and lipid metabolism of non-exudative age-related macular degeneration Guoji Yanke Zazhi non-exudative age-related macular degeneration microrna oxidative stress lipid metabolism retinal pigment epithelium nuclear factor erythrocyte 2 related factor atp binding cassette transporter a1 |
| title | Research progress of microRNA in oxidative stress and lipid metabolism of non-exudative age-related macular degeneration |
| title_full | Research progress of microRNA in oxidative stress and lipid metabolism of non-exudative age-related macular degeneration |
| title_fullStr | Research progress of microRNA in oxidative stress and lipid metabolism of non-exudative age-related macular degeneration |
| title_full_unstemmed | Research progress of microRNA in oxidative stress and lipid metabolism of non-exudative age-related macular degeneration |
| title_short | Research progress of microRNA in oxidative stress and lipid metabolism of non-exudative age-related macular degeneration |
| title_sort | research progress of microrna in oxidative stress and lipid metabolism of non exudative age related macular degeneration |
| topic | non-exudative age-related macular degeneration microrna oxidative stress lipid metabolism retinal pigment epithelium nuclear factor erythrocyte 2 related factor atp binding cassette transporter a1 |
| url | http://ies.ijo.cn/cn_publish/2024/4/202404012.pdf |
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