Global DNA methylation and cognitive and behavioral outcomes at 4 years of age: A cross‐sectional study
Abstract Background Accumulating evidence suggests that breastfeeding exclusivity and duration are positively associated with child cognition. This study investigated whether DNA methylation, an epigenetic mechanism modified by nutrient intake, may contribute to the link between breastfeeding and ch...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-04-01
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| Series: | Brain and Behavior |
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| Online Access: | https://doi.org/10.1002/brb3.1579 |
| _version_ | 1818085616069378048 |
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| author | Rachael M. Taylor Roger Smith Clare E. Collins David Mossman Michelle W. Wong‐Brown Eng‐Cheng Chan Tiffany‐Jane Evans John R. Attia Nick Buckley Karen Drysdale Tenele Smith Trent Butler Alexis J. Hure |
| author_facet | Rachael M. Taylor Roger Smith Clare E. Collins David Mossman Michelle W. Wong‐Brown Eng‐Cheng Chan Tiffany‐Jane Evans John R. Attia Nick Buckley Karen Drysdale Tenele Smith Trent Butler Alexis J. Hure |
| author_sort | Rachael M. Taylor |
| collection | DOAJ |
| description | Abstract Background Accumulating evidence suggests that breastfeeding exclusivity and duration are positively associated with child cognition. This study investigated whether DNA methylation, an epigenetic mechanism modified by nutrient intake, may contribute to the link between breastfeeding and child cognition. The aim was to quantify the relationship between global DNA methylation and cognition and behavior at 4 years of age. Methods Child behavior and cognition were measured at age 4 years using the Wechsler Preschool and Primary Scale of Intelligence, third version (WPPSI‐III), and Child Behavior Checklist (CBC). Global DNA methylation (%5‐methylcytosines (%5mC)) was measured in buccal cells at age 4 years, using an enzyme‐linked immunosorbent assay (ELISA) commercial kit. Linear regression models were used to quantify the statistical relationships. Results Data were collected from 73 children recruited from the Women and Their Children's Health (WATCH) study. No statistically significant associations were found between global DNA methylation levels and child cognition or behavior (p > .05), though the estimates of effect were consistently negative. Global DNA methylation levels in males were significantly higher than in females (median %5mC: 1.82 vs. 1.03, males and females, respectively, (p < .05)). Conclusion No association was found between global DNA methylation and child cognition and behavior; however given the small sample, this study should be pooled with other cohorts in future meta‐analyses. |
| first_indexed | 2024-12-10T20:12:37Z |
| format | Article |
| id | doaj.art-8269222a7cf24832ac287fd521ee66a8 |
| institution | Directory Open Access Journal |
| issn | 2162-3279 |
| language | English |
| last_indexed | 2024-12-10T20:12:37Z |
| publishDate | 2020-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain and Behavior |
| spelling | doaj.art-8269222a7cf24832ac287fd521ee66a82022-12-22T01:35:16ZengWileyBrain and Behavior2162-32792020-04-01104n/an/a10.1002/brb3.1579Global DNA methylation and cognitive and behavioral outcomes at 4 years of age: A cross‐sectional studyRachael M. Taylor0Roger Smith1Clare E. Collins2David Mossman3Michelle W. Wong‐Brown4Eng‐Cheng Chan5Tiffany‐Jane Evans6John R. Attia7Nick Buckley8Karen Drysdale9Tenele Smith10Trent Butler11Alexis J. Hure12Priority Research Centre for Reproductive Science University of Newcastle Callaghan NSW AustraliaPriority Research Centre for Reproductive Science University of Newcastle Callaghan NSW AustraliaFaculty of Health and Medicine School of Medicine and Public Health University of Newcastle Callaghan NSW AustraliaHunter Medical Research Institute New Lambton Heights NSW AustraliaHunter Medical Research Institute New Lambton Heights NSW AustraliaPriority Research Centre for Reproductive Science University of Newcastle Callaghan NSW AustraliaHunter Medical Research Institute New Lambton Heights NSW AustraliaFaculty of Health and Medicine School of Medicine and Public Health University of Newcastle Callaghan NSW AustraliaSchool of Psychology and Exercise Science Murdoch University Murdoch WA AustraliaFaculty of Science School Psychology University of Newcastle Callaghan NSW AustraliaPriority Research Centre for Reproductive Science University of Newcastle Callaghan NSW AustraliaPriority Research Centre for Reproductive Science University of Newcastle Callaghan NSW AustraliaFaculty of Health and Medicine School of Medicine and Public Health University of Newcastle Callaghan NSW AustraliaAbstract Background Accumulating evidence suggests that breastfeeding exclusivity and duration are positively associated with child cognition. This study investigated whether DNA methylation, an epigenetic mechanism modified by nutrient intake, may contribute to the link between breastfeeding and child cognition. The aim was to quantify the relationship between global DNA methylation and cognition and behavior at 4 years of age. Methods Child behavior and cognition were measured at age 4 years using the Wechsler Preschool and Primary Scale of Intelligence, third version (WPPSI‐III), and Child Behavior Checklist (CBC). Global DNA methylation (%5‐methylcytosines (%5mC)) was measured in buccal cells at age 4 years, using an enzyme‐linked immunosorbent assay (ELISA) commercial kit. Linear regression models were used to quantify the statistical relationships. Results Data were collected from 73 children recruited from the Women and Their Children's Health (WATCH) study. No statistically significant associations were found between global DNA methylation levels and child cognition or behavior (p > .05), though the estimates of effect were consistently negative. Global DNA methylation levels in males were significantly higher than in females (median %5mC: 1.82 vs. 1.03, males and females, respectively, (p < .05)). Conclusion No association was found between global DNA methylation and child cognition and behavior; however given the small sample, this study should be pooled with other cohorts in future meta‐analyses.https://doi.org/10.1002/brb3.1579behaviorcognitionglobal DNA methylationnutritionone‐carbon metabolismpostnatal |
| spellingShingle | Rachael M. Taylor Roger Smith Clare E. Collins David Mossman Michelle W. Wong‐Brown Eng‐Cheng Chan Tiffany‐Jane Evans John R. Attia Nick Buckley Karen Drysdale Tenele Smith Trent Butler Alexis J. Hure Global DNA methylation and cognitive and behavioral outcomes at 4 years of age: A cross‐sectional study Brain and Behavior behavior cognition global DNA methylation nutrition one‐carbon metabolism postnatal |
| title | Global DNA methylation and cognitive and behavioral outcomes at 4 years of age: A cross‐sectional study |
| title_full | Global DNA methylation and cognitive and behavioral outcomes at 4 years of age: A cross‐sectional study |
| title_fullStr | Global DNA methylation and cognitive and behavioral outcomes at 4 years of age: A cross‐sectional study |
| title_full_unstemmed | Global DNA methylation and cognitive and behavioral outcomes at 4 years of age: A cross‐sectional study |
| title_short | Global DNA methylation and cognitive and behavioral outcomes at 4 years of age: A cross‐sectional study |
| title_sort | global dna methylation and cognitive and behavioral outcomes at 4 years of age a cross sectional study |
| topic | behavior cognition global DNA methylation nutrition one‐carbon metabolism postnatal |
| url | https://doi.org/10.1002/brb3.1579 |
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