TGF-β in the Secretome of Irradiated Peripheral Blood Mononuclear Cells Supports In Vitro Osteoclastogenesis

TGF-β in the Secretome of Irradiated Peripheral Blood Mononuclear Cells Supports In Vitro Osteoclastogenesis

Osteoclastogenesis required for bone remodeling is also a key pathologic mechanism of inflammatory osteolysis being controlled by paracrine factors released from dying cells. The secretome of irradiated, dying peripheral blood mononuclear cells (PBMCs) has a major impact on the differentiation of my...

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Bibliographic Details
Main Authors: Layla Panahipour, Zahra Kargarpour, Maria Laggner, Michael Mildner, Hendrik J. Ankersmit, Reinhard Gruber
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:International Journal of Molecular Sciences
Subjects:
wound healing
secretome
osteoclastogenesis
macrophages
apoptosis
necroptosis
Online Access:https://www.mdpi.com/1422-0067/21/22/8569

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