Chemerin-Derived Peptide Val66-Pro85 Is Effective in Limiting Methicillin-Resistant S. aureus Skin Infection
Chemerin-derived peptide Val66-Pro85 (p4) restricts the growth of a variety of skin-associated bacteria, including methicillin-resistant Staphylococcus aureus (MRSA). To better understand the antimicrobial potential of chemerin peptide, we compared p4 activity against MRSA in vitro to cathelicidin L...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-11-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2021.742610/full |
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| author | Aneta Zegar Urszula Godlewska Dorota Kozłowska-Chmielewska Pawel Majewski Brian A. Zabel Joanna Cichy |
| author_facet | Aneta Zegar Urszula Godlewska Dorota Kozłowska-Chmielewska Pawel Majewski Brian A. Zabel Joanna Cichy |
| author_sort | Aneta Zegar |
| collection | DOAJ |
| description | Chemerin-derived peptide Val66-Pro85 (p4) restricts the growth of a variety of skin-associated bacteria, including methicillin-resistant Staphylococcus aureus (MRSA). To better understand the antimicrobial potential of chemerin peptide, we compared p4 activity against MRSA in vitro to cathelicidin LL-37, one of the key endogenous peptides implicated in controlling the growth of S. aureus. The efficacy of p4 was also validated in relevant experimental models of skin pathology, such as topical skin infection with community-acquired MRSA, and in the context of skin inflammatory diseases commonly associated with colonization with S. aureus, such as atopic dermatitis (AD). We showed that p4 collaborates additively with LL-37 in inhibiting the growth of S. aureus, including MRSA, and that p4 was effective in vivo in reducing MRSA burden. p4 was also effective in reducing levels of skin-infiltrating leukocytes in S. aureus-infected AD-like skin. Taken together, our data suggest that p4 is effective in limiting S. aureus and, in particular, MRSA skin infection. |
| first_indexed | 2024-12-17T19:55:16Z |
| format | Article |
| id | doaj.art-826ac63c81f94f57b55dd8efadd10770 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-17T19:55:16Z |
| publishDate | 2021-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-826ac63c81f94f57b55dd8efadd107702022-12-21T21:34:36ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2021-11-011210.3389/fmicb.2021.742610742610Chemerin-Derived Peptide Val66-Pro85 Is Effective in Limiting Methicillin-Resistant S. aureus Skin InfectionAneta Zegar0Urszula Godlewska1Dorota Kozłowska-Chmielewska2Pawel Majewski3Brian A. Zabel4Joanna Cichy5Department of Immunology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Kraków, PolandDepartment of Immunology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Kraków, PolandDepartment of Immunology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Kraków, PolandDepartment of Immunology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Kraków, PolandPalo Alto Veterans Institute for Research, VA Palo Alto Health Care System, Palo Alto, CA, United StatesDepartment of Immunology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Kraków, PolandChemerin-derived peptide Val66-Pro85 (p4) restricts the growth of a variety of skin-associated bacteria, including methicillin-resistant Staphylococcus aureus (MRSA). To better understand the antimicrobial potential of chemerin peptide, we compared p4 activity against MRSA in vitro to cathelicidin LL-37, one of the key endogenous peptides implicated in controlling the growth of S. aureus. The efficacy of p4 was also validated in relevant experimental models of skin pathology, such as topical skin infection with community-acquired MRSA, and in the context of skin inflammatory diseases commonly associated with colonization with S. aureus, such as atopic dermatitis (AD). We showed that p4 collaborates additively with LL-37 in inhibiting the growth of S. aureus, including MRSA, and that p4 was effective in vivo in reducing MRSA burden. p4 was also effective in reducing levels of skin-infiltrating leukocytes in S. aureus-infected AD-like skin. Taken together, our data suggest that p4 is effective in limiting S. aureus and, in particular, MRSA skin infection.https://www.frontiersin.org/articles/10.3389/fmicb.2021.742610/fullantimicrobial peptideschemerinskinMRSA—methicillin-resistant Staphylococcus aureusatopic dermatitis |
| spellingShingle | Aneta Zegar Urszula Godlewska Dorota Kozłowska-Chmielewska Pawel Majewski Brian A. Zabel Joanna Cichy Chemerin-Derived Peptide Val66-Pro85 Is Effective in Limiting Methicillin-Resistant S. aureus Skin Infection Frontiers in Microbiology antimicrobial peptides chemerin skin MRSA—methicillin-resistant Staphylococcus aureus atopic dermatitis |
| title | Chemerin-Derived Peptide Val66-Pro85 Is Effective in Limiting Methicillin-Resistant S. aureus Skin Infection |
| title_full | Chemerin-Derived Peptide Val66-Pro85 Is Effective in Limiting Methicillin-Resistant S. aureus Skin Infection |
| title_fullStr | Chemerin-Derived Peptide Val66-Pro85 Is Effective in Limiting Methicillin-Resistant S. aureus Skin Infection |
| title_full_unstemmed | Chemerin-Derived Peptide Val66-Pro85 Is Effective in Limiting Methicillin-Resistant S. aureus Skin Infection |
| title_short | Chemerin-Derived Peptide Val66-Pro85 Is Effective in Limiting Methicillin-Resistant S. aureus Skin Infection |
| title_sort | chemerin derived peptide val66 pro85 is effective in limiting methicillin resistant s aureus skin infection |
| topic | antimicrobial peptides chemerin skin MRSA—methicillin-resistant Staphylococcus aureus atopic dermatitis |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2021.742610/full |
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