Biventricular Strain Imaging with Cardiac MRI in Genotyped and Histology Validated Amyloid Cardiomyopathy
Cardiac amyloidosis (CA) is a common and potentially fatal infiltrative cardiomyopathy. Contrast-enhanced cardiac MRI (CMR) is used as a diagnostic tool. However, utility of CMR for the comprehensive analysis of biventricular strains and strain rates is not reported as extensively as echocardiograph...
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| Format: | Article |
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MDPI AG
2021-06-01
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| Series: | Cardiogenetics |
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| Online Access: | https://www.mdpi.com/2035-8148/11/3/11 |
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| author | Abhinay Reddy Vasvi Singh Badri Karthikeyan Leyi Jiang Silva Kristo Sharma Kattel Ram Amuthan Saraswati Pokharel Umesh C. Sharma |
| author_facet | Abhinay Reddy Vasvi Singh Badri Karthikeyan Leyi Jiang Silva Kristo Sharma Kattel Ram Amuthan Saraswati Pokharel Umesh C. Sharma |
| author_sort | Abhinay Reddy |
| collection | DOAJ |
| description | Cardiac amyloidosis (CA) is a common and potentially fatal infiltrative cardiomyopathy. Contrast-enhanced cardiac MRI (CMR) is used as a diagnostic tool. However, utility of CMR for the comprehensive analysis of biventricular strains and strain rates is not reported as extensively as echocardiography. In addition, RV strain analysis using CMR has not been described previously. <b>Objectives:</b> We sought to study the global and regional indices of biventricular strain and strain rates in endomyocardial biopsy (EMB)-proven, genotyped cases of CA. <b>Methods:</b> A database of 80 EMBs was curated from 2012 to 2019 based on histology. A total of 19 EMBs positive for CA were subjected to further tissue-characterization with histology, and compared with four normal biopsy specimens. Samples were genotyped for ATTR- or AL-subtypes. Five patients, with both echocardiography and contrast-enhanced CMR performed 72-h apart, were subjected to comprehensive analysis of biventricular strain and strain-rates. <b>Results:</b> Histology confirmed that the selected samples were indeed positive for cardiac amyloid. Echocardiography showed reduced global and regional left-ventricular (LV) longitudinal strain indices. CMR with tissue-characterization of LV showed global reductions in circumferential, radial and longitudinal strains and strain-rates, following a general trend with the echocardiographic findings. The basal right-ventricular (RV) segments had reduced circumferential strains with no changes in longitudinal strain. <b>Conclusions:</b> In addition to providing a clinical diagnosis of CA based on contrast clearance-dynamics, CMR can be a potent tool for accurate functional assessment of global and regional changes in strain and strain-rates involving both LV and RV. Further studies are warranted to validate and curate the strain imaging capacity of CMR in CA. |
| first_indexed | 2024-03-10T09:54:51Z |
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| issn | 2035-8253 2035-8148 |
| language | English |
| last_indexed | 2024-03-10T09:54:51Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cardiogenetics |
| spelling | doaj.art-826bfc9fb13a49d0a59dea106e7a72312023-11-22T02:27:16ZengMDPI AGCardiogenetics2035-82532035-81482021-06-011139811010.3390/cardiogenetics11030011Biventricular Strain Imaging with Cardiac MRI in Genotyped and Histology Validated Amyloid CardiomyopathyAbhinay Reddy0Vasvi Singh1Badri Karthikeyan2Leyi Jiang3Silva Kristo4Sharma Kattel5Ram Amuthan6Saraswati Pokharel7Umesh C. Sharma8Department of Medicine, Division of Cardiology, Jacob’s School of Medicine and Biomedical Sciences, Buffalo, NY 14203, USADepartment of Radiology, Division of Nuclear Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USADepartment of Medicine, Division of Cardiology, Jacob’s School of Medicine and Biomedical Sciences, Buffalo, NY 14203, USADepartment of Medicine, Division of Cardiology, Jacob’s School of Medicine and Biomedical Sciences, Buffalo, NY 14203, USADepartment of Pathology and Laboratory Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14203, USADepartment of Medicine, Division of Cardiology, Jacob’s School of Medicine and Biomedical Sciences, Buffalo, NY 14203, USADepartment of Medicine, Division of Cardiology, Jacob’s School of Medicine and Biomedical Sciences, Buffalo, NY 14203, USADepartment of Pathology and Laboratory Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14203, USADepartment of Medicine, Division of Cardiology, Jacob’s School of Medicine and Biomedical Sciences, Buffalo, NY 14203, USACardiac amyloidosis (CA) is a common and potentially fatal infiltrative cardiomyopathy. Contrast-enhanced cardiac MRI (CMR) is used as a diagnostic tool. However, utility of CMR for the comprehensive analysis of biventricular strains and strain rates is not reported as extensively as echocardiography. In addition, RV strain analysis using CMR has not been described previously. <b>Objectives:</b> We sought to study the global and regional indices of biventricular strain and strain rates in endomyocardial biopsy (EMB)-proven, genotyped cases of CA. <b>Methods:</b> A database of 80 EMBs was curated from 2012 to 2019 based on histology. A total of 19 EMBs positive for CA were subjected to further tissue-characterization with histology, and compared with four normal biopsy specimens. Samples were genotyped for ATTR- or AL-subtypes. Five patients, with both echocardiography and contrast-enhanced CMR performed 72-h apart, were subjected to comprehensive analysis of biventricular strain and strain-rates. <b>Results:</b> Histology confirmed that the selected samples were indeed positive for cardiac amyloid. Echocardiography showed reduced global and regional left-ventricular (LV) longitudinal strain indices. CMR with tissue-characterization of LV showed global reductions in circumferential, radial and longitudinal strains and strain-rates, following a general trend with the echocardiographic findings. The basal right-ventricular (RV) segments had reduced circumferential strains with no changes in longitudinal strain. <b>Conclusions:</b> In addition to providing a clinical diagnosis of CA based on contrast clearance-dynamics, CMR can be a potent tool for accurate functional assessment of global and regional changes in strain and strain-rates involving both LV and RV. Further studies are warranted to validate and curate the strain imaging capacity of CMR in CA.https://www.mdpi.com/2035-8148/11/3/11amyloidosiscardiac MRIendomyocardial biopsystrain imaging |
| spellingShingle | Abhinay Reddy Vasvi Singh Badri Karthikeyan Leyi Jiang Silva Kristo Sharma Kattel Ram Amuthan Saraswati Pokharel Umesh C. Sharma Biventricular Strain Imaging with Cardiac MRI in Genotyped and Histology Validated Amyloid Cardiomyopathy Cardiogenetics amyloidosis cardiac MRI endomyocardial biopsy strain imaging |
| title | Biventricular Strain Imaging with Cardiac MRI in Genotyped and Histology Validated Amyloid Cardiomyopathy |
| title_full | Biventricular Strain Imaging with Cardiac MRI in Genotyped and Histology Validated Amyloid Cardiomyopathy |
| title_fullStr | Biventricular Strain Imaging with Cardiac MRI in Genotyped and Histology Validated Amyloid Cardiomyopathy |
| title_full_unstemmed | Biventricular Strain Imaging with Cardiac MRI in Genotyped and Histology Validated Amyloid Cardiomyopathy |
| title_short | Biventricular Strain Imaging with Cardiac MRI in Genotyped and Histology Validated Amyloid Cardiomyopathy |
| title_sort | biventricular strain imaging with cardiac mri in genotyped and histology validated amyloid cardiomyopathy |
| topic | amyloidosis cardiac MRI endomyocardial biopsy strain imaging |
| url | https://www.mdpi.com/2035-8148/11/3/11 |
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