An animal model of a spontaneously reversible obstructive sleep apnea syndrome in the monkey
The anatomies of the tongue and uvula in monkeys share many similarities with humans, such that this species has the closest approximation to the human upper airway than any other species. In this study, we investigated the feasibility of using small monkeys as experimental animals for an obstructiv...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2005-11-01
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| Series: | Neurobiology of Disease |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996105001117 |
| _version_ | 1818573111499423744 |
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| author | P. Philip C.E. Gross J. Taillard B. Bioulac C. Guilleminault |
| author_facet | P. Philip C.E. Gross J. Taillard B. Bioulac C. Guilleminault |
| author_sort | P. Philip |
| collection | DOAJ |
| description | The anatomies of the tongue and uvula in monkeys share many similarities with humans, such that this species has the closest approximation to the human upper airway than any other species. In this study, we investigated the feasibility of using small monkeys as experimental animals for an obstructive sleep apnea model.Monkeys received intradermal injections of liquid collagen in the uvula, tongue, and lateral pharyngeal walls every 2 weeks. Polysomnography was performed bi-monthly in order to control the impact of injections on breathing events, respiratory effort (as measured by esophageal pressure), and sleep.Before injections, the three animals showed normal breathing during sleep with a mean of 4.8 ± 2.0 events/h. After injections, a mean of 27.9 ± 19.7 hypopneas/h was recorded (P = 0.023). Total sleep time was significantly reduced, with a decrease of REM sleep and stage II sleep; however, stage I sleep increased.Collagen injections in monkey's upper airways can create sleep-disordered breathing and abnormal sleep, as seen in sleep apneic patients. |
| first_indexed | 2024-12-15T00:06:43Z |
| format | Article |
| id | doaj.art-826dc1a691b241c1bcd400b980b1c799 |
| institution | Directory Open Access Journal |
| issn | 1095-953X |
| language | English |
| last_indexed | 2024-12-15T00:06:43Z |
| publishDate | 2005-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Disease |
| spelling | doaj.art-826dc1a691b241c1bcd400b980b1c7992022-12-21T22:42:42ZengElsevierNeurobiology of Disease1095-953X2005-11-01202428431An animal model of a spontaneously reversible obstructive sleep apnea syndrome in the monkeyP. Philip0C.E. Gross1J. Taillard2B. Bioulac3C. Guilleminault4Clinique du Sommeil, CHU Pellegrin, Bordeaux, France; CNRS UMR-5543, Université Victor Segalen, Bordeaux, France; Corresponding author. Clinique du sommeil, CHU Pellegrin, 33076 Bordeaux Cedex, France. Fax: +33 5 56 79 48 06.Clinique du Sommeil, CHU Pellegrin, Bordeaux, France; CNRS UMR-5543, Université Victor Segalen, Bordeaux, FranceClinique du Sommeil, CHU Pellegrin, Bordeaux, France; CNRS UMR-5543, Université Victor Segalen, Bordeaux, FranceClinique du Sommeil, CHU Pellegrin, Bordeaux, France; CNRS UMR-5543, Université Victor Segalen, Bordeaux, FranceStanford University, Sleep Research Center, Stanford, CA 94305, USAThe anatomies of the tongue and uvula in monkeys share many similarities with humans, such that this species has the closest approximation to the human upper airway than any other species. In this study, we investigated the feasibility of using small monkeys as experimental animals for an obstructive sleep apnea model.Monkeys received intradermal injections of liquid collagen in the uvula, tongue, and lateral pharyngeal walls every 2 weeks. Polysomnography was performed bi-monthly in order to control the impact of injections on breathing events, respiratory effort (as measured by esophageal pressure), and sleep.Before injections, the three animals showed normal breathing during sleep with a mean of 4.8 ± 2.0 events/h. After injections, a mean of 27.9 ± 19.7 hypopneas/h was recorded (P = 0.023). Total sleep time was significantly reduced, with a decrease of REM sleep and stage II sleep; however, stage I sleep increased.Collagen injections in monkey's upper airways can create sleep-disordered breathing and abnormal sleep, as seen in sleep apneic patients.http://www.sciencedirect.com/science/article/pii/S0969996105001117MonkeyAnimal modelObstructive sleep apneaSleep |
| spellingShingle | P. Philip C.E. Gross J. Taillard B. Bioulac C. Guilleminault An animal model of a spontaneously reversible obstructive sleep apnea syndrome in the monkey Neurobiology of Disease Monkey Animal model Obstructive sleep apnea Sleep |
| title | An animal model of a spontaneously reversible obstructive sleep apnea syndrome in the monkey |
| title_full | An animal model of a spontaneously reversible obstructive sleep apnea syndrome in the monkey |
| title_fullStr | An animal model of a spontaneously reversible obstructive sleep apnea syndrome in the monkey |
| title_full_unstemmed | An animal model of a spontaneously reversible obstructive sleep apnea syndrome in the monkey |
| title_short | An animal model of a spontaneously reversible obstructive sleep apnea syndrome in the monkey |
| title_sort | animal model of a spontaneously reversible obstructive sleep apnea syndrome in the monkey |
| topic | Monkey Animal model Obstructive sleep apnea Sleep |
| url | http://www.sciencedirect.com/science/article/pii/S0969996105001117 |
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