Rapid Domoic Acid Depuration in the Scallop <i>Argopecten purpuratus</i> and Its Transfer from the Digestive Gland to Other Organs
Domoic acid (DA), the main toxin responsible for Amnesic Shellfish Poisoning, frequently affects the marine resources of Chile and other countries across the South Pacific, thus becoming a risk for human health. One of the affected resources is the scallop <i>Argopecten purpuratus</i>. E...
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| Format: | Article |
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MDPI AG
2020-11-01
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| Series: | Toxins |
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| Online Access: | https://www.mdpi.com/2072-6651/12/11/698 |
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| author | Gonzalo Álvarez José Rengel Michael Araya Francisco Álvarez Roberto Pino Eduardo Uribe Patricio A. Díaz Araceli E. Rossignoli Américo López-Rivera Juan Blanco |
| author_facet | Gonzalo Álvarez José Rengel Michael Araya Francisco Álvarez Roberto Pino Eduardo Uribe Patricio A. Díaz Araceli E. Rossignoli Américo López-Rivera Juan Blanco |
| author_sort | Gonzalo Álvarez |
| collection | DOAJ |
| description | Domoic acid (DA), the main toxin responsible for Amnesic Shellfish Poisoning, frequently affects the marine resources of Chile and other countries across the South Pacific, thus becoming a risk for human health. One of the affected resources is the scallop <i>Argopecten purpuratus</i>. Even though this species has a high commercial importance in Northern Chile and Peru, the characteristics of its DA depuration are not known. In this work, the DA depuration was studied by means of two experiments: one in controlled (laboratory) and another in natural conditions. All organs of <i>A. purpuratus</i> depurated the toxin very quickly in both experiments. In some organs, an increase or a very small decrease of toxin was detected in the early depuration steps. Several models were used to describe this kinetics. The one that included toxin transfer between organs and independent depuration from each organ was the model that best fit the data. It seems, therefore, that the DA in this species is quickly transferred from the digestive gland to all other organs, which release it into the environment. Physiological differences in the two experiments have been shown to have some effect on the depuration from each organ but the actual reasons are still unknown. |
| first_indexed | 2024-03-10T15:07:07Z |
| format | Article |
| id | doaj.art-826edcbda2794b328d64ada3fe79e5df |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-03-10T15:07:07Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-826edcbda2794b328d64ada3fe79e5df2023-11-20T19:38:21ZengMDPI AGToxins2072-66512020-11-01121169810.3390/toxins12110698Rapid Domoic Acid Depuration in the Scallop <i>Argopecten purpuratus</i> and Its Transfer from the Digestive Gland to Other OrgansGonzalo Álvarez0José Rengel1Michael Araya2Francisco Álvarez3Roberto Pino4Eduardo Uribe5Patricio A. Díaz6Araceli E. Rossignoli7Américo López-Rivera8Juan Blanco9Facultad de Ciencias del Mar, Departamento de Acuicultura, Universidad Católica del Norte, Coquimbo 1281, ChileFacultad de Ciencias del Mar, Departamento de Acuicultura, Universidad Católica del Norte, Coquimbo 1281, ChileCentro de Investigación y Desarrollo Tecnológico en Algas (CIDTA), Facultad de Ciencias del Mar, Universidad Católica del Norte, Coquimbo 1281, ChileFacultad de Ciencias del Mar, Departamento de Acuicultura, Universidad Católica del Norte, Coquimbo 1281, ChileFacultad de Ciencias del Mar, Departamento de Acuicultura, Universidad Católica del Norte, Coquimbo 1281, ChileFacultad de Ciencias del Mar, Departamento de Acuicultura, Universidad Católica del Norte, Coquimbo 1281, ChileCentro i∼mar & CeBiB, Universidad de Los Lagos, Puerto Montt 557, ChileCentro de Investigacións Mariñas (Xunta de Galicia), Apto. 13, 36620 Vilanova de Arousa, Pontevedra, SpainLaboratorio de Toxinas Marinas, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Santiago 1027, ChileCentro de Investigacións Mariñas (Xunta de Galicia), Apto. 13, 36620 Vilanova de Arousa, Pontevedra, SpainDomoic acid (DA), the main toxin responsible for Amnesic Shellfish Poisoning, frequently affects the marine resources of Chile and other countries across the South Pacific, thus becoming a risk for human health. One of the affected resources is the scallop <i>Argopecten purpuratus</i>. Even though this species has a high commercial importance in Northern Chile and Peru, the characteristics of its DA depuration are not known. In this work, the DA depuration was studied by means of two experiments: one in controlled (laboratory) and another in natural conditions. All organs of <i>A. purpuratus</i> depurated the toxin very quickly in both experiments. In some organs, an increase or a very small decrease of toxin was detected in the early depuration steps. Several models were used to describe this kinetics. The one that included toxin transfer between organs and independent depuration from each organ was the model that best fit the data. It seems, therefore, that the DA in this species is quickly transferred from the digestive gland to all other organs, which release it into the environment. Physiological differences in the two experiments have been shown to have some effect on the depuration from each organ but the actual reasons are still unknown.https://www.mdpi.com/2072-6651/12/11/698ASPamnesic shellfish poisoningdetoxificationNorthern Chiletoxicokineticsmodeling |
| spellingShingle | Gonzalo Álvarez José Rengel Michael Araya Francisco Álvarez Roberto Pino Eduardo Uribe Patricio A. Díaz Araceli E. Rossignoli Américo López-Rivera Juan Blanco Rapid Domoic Acid Depuration in the Scallop <i>Argopecten purpuratus</i> and Its Transfer from the Digestive Gland to Other Organs Toxins ASP amnesic shellfish poisoning detoxification Northern Chile toxicokinetics modeling |
| title | Rapid Domoic Acid Depuration in the Scallop <i>Argopecten purpuratus</i> and Its Transfer from the Digestive Gland to Other Organs |
| title_full | Rapid Domoic Acid Depuration in the Scallop <i>Argopecten purpuratus</i> and Its Transfer from the Digestive Gland to Other Organs |
| title_fullStr | Rapid Domoic Acid Depuration in the Scallop <i>Argopecten purpuratus</i> and Its Transfer from the Digestive Gland to Other Organs |
| title_full_unstemmed | Rapid Domoic Acid Depuration in the Scallop <i>Argopecten purpuratus</i> and Its Transfer from the Digestive Gland to Other Organs |
| title_short | Rapid Domoic Acid Depuration in the Scallop <i>Argopecten purpuratus</i> and Its Transfer from the Digestive Gland to Other Organs |
| title_sort | rapid domoic acid depuration in the scallop i argopecten purpuratus i and its transfer from the digestive gland to other organs |
| topic | ASP amnesic shellfish poisoning detoxification Northern Chile toxicokinetics modeling |
| url | https://www.mdpi.com/2072-6651/12/11/698 |
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