Rscreenorm: normalization of CRISPR and siRNA screen data for more reproducible hit selection
Abstract Background Reproducibility of hits from independent CRISPR or siRNA screens is poor. This is partly due to data normalization primarily addressing technical variability within independent screens, and not the technical differences between them. Results We present “rscreenorm”, a method that...
Main Authors: | Costa Bachas, Jasmina Hodzic, Johannes C. van der Mijn, Chantal Stoepker, Henk M. W. Verheul, Rob M. F. Wolthuis, Emanuela Felley-Bosco, Wessel N. van Wieringen, Victor W. van Beusechem, Ruud H. Brakenhoff, Renée X. de Menezes |
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Format: | Article |
Language: | English |
Published: |
BMC
2018-08-01
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Series: | BMC Bioinformatics |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s12859-018-2306-z |
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