Microfluidic-assisted preparation of PLGA nanoparticles for drug delivery purposes: experimental study and computational fluid dynamic simulation

This study, for the first time, tries to provide a simultaneous experimental and computational fluid dynamic (CFD) simulation investigation for production of uniform, reproducible, and stable polylactic-co-glycolic acid (PLGA) nanoparticles. CFD simulation was carried out to observe fluid flow behav...

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Main Authors: Parisa Shokoohinia, Marziyeh Hajialyani, Komail Sadrjavadi, Mona Akbari, Masoud Rahimi, Salar Khaledian, Ali Fattahi
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2019-01-01
Series:Research in Pharmaceutical Sciences
Subjects:
Online Access:http://www.rpsjournal.net/article.asp?issn=1735-5362;year=2019;volume=14;issue=5;spage=459;epage=470;aulast=Shokoohinia
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author Parisa Shokoohinia
Marziyeh Hajialyani
Komail Sadrjavadi
Mona Akbari
Masoud Rahimi
Salar Khaledian
Ali Fattahi
author_facet Parisa Shokoohinia
Marziyeh Hajialyani
Komail Sadrjavadi
Mona Akbari
Masoud Rahimi
Salar Khaledian
Ali Fattahi
author_sort Parisa Shokoohinia
collection DOAJ
description This study, for the first time, tries to provide a simultaneous experimental and computational fluid dynamic (CFD) simulation investigation for production of uniform, reproducible, and stable polylactic-co-glycolic acid (PLGA) nanoparticles. CFD simulation was carried out to observe fluid flow behavior and micromixing in microfluidic system and improve our understanding about the governing fluid profile. The major objective of such effort was to provide a carrier for controlled and sustained release profile of different drugs. Different experimental parameters were optimized to obtain PLGA nanoparticles with proper size and minimized polydispersity index. The particle size, polydispersity, morphology, and stability of nanoparticles were compared. Microfluidic system provided a platform to control over the characteristics of nanoparticles. Using microfluidic system, the obtained particles were more uniform and harmonious in size, more stable, monodisperse and spherical, while particles produced by batch method were non-spherical and polydisperse. The best size and polydispersity index in the microfluidic method was obtained using 2% PLGA and 0.0625% (w/v) polyvinyl alcohol (PVA) solutions, and the flow rate ratio of 10:0.6 for PVA and PLGA solutions. CFD simulation demonstrated the high mixing intensity of about 0.99 at optimum condition in the microfluidic system, which is the possible reason for advantageous performance of this system. Altogether, the results of microfluidic-assisted method were found to be more reproducible, predictable, and controllable than batch method for producing a nanoformulation for delivery of drugs.
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spelling doaj.art-8272bc0bf6cf45c498826f6fa8308aa92022-12-21T22:53:55ZengWolters Kluwer Medknow PublicationsResearch in Pharmaceutical Sciences1735-53621735-94142019-01-0114545947010.4103/1735-5362.268207Microfluidic-assisted preparation of PLGA nanoparticles for drug delivery purposes: experimental study and computational fluid dynamic simulationParisa ShokoohiniaMarziyeh HajialyaniKomail SadrjavadiMona AkbariMasoud RahimiSalar KhaledianAli FattahiThis study, for the first time, tries to provide a simultaneous experimental and computational fluid dynamic (CFD) simulation investigation for production of uniform, reproducible, and stable polylactic-co-glycolic acid (PLGA) nanoparticles. CFD simulation was carried out to observe fluid flow behavior and micromixing in microfluidic system and improve our understanding about the governing fluid profile. The major objective of such effort was to provide a carrier for controlled and sustained release profile of different drugs. Different experimental parameters were optimized to obtain PLGA nanoparticles with proper size and minimized polydispersity index. The particle size, polydispersity, morphology, and stability of nanoparticles were compared. Microfluidic system provided a platform to control over the characteristics of nanoparticles. Using microfluidic system, the obtained particles were more uniform and harmonious in size, more stable, monodisperse and spherical, while particles produced by batch method were non-spherical and polydisperse. The best size and polydispersity index in the microfluidic method was obtained using 2% PLGA and 0.0625% (w/v) polyvinyl alcohol (PVA) solutions, and the flow rate ratio of 10:0.6 for PVA and PLGA solutions. CFD simulation demonstrated the high mixing intensity of about 0.99 at optimum condition in the microfluidic system, which is the possible reason for advantageous performance of this system. Altogether, the results of microfluidic-assisted method were found to be more reproducible, predictable, and controllable than batch method for producing a nanoformulation for delivery of drugs.http://www.rpsjournal.net/article.asp?issn=1735-5362;year=2019;volume=14;issue=5;spage=459;epage=470;aulast=Shokoohiniacomputational fluid dynamic; microfluidics; nanoparticles; nanoprecipitation; polylactic-co- glycolicacid.
spellingShingle Parisa Shokoohinia
Marziyeh Hajialyani
Komail Sadrjavadi
Mona Akbari
Masoud Rahimi
Salar Khaledian
Ali Fattahi
Microfluidic-assisted preparation of PLGA nanoparticles for drug delivery purposes: experimental study and computational fluid dynamic simulation
Research in Pharmaceutical Sciences
computational fluid dynamic; microfluidics; nanoparticles; nanoprecipitation; polylactic-co- glycolicacid.
title Microfluidic-assisted preparation of PLGA nanoparticles for drug delivery purposes: experimental study and computational fluid dynamic simulation
title_full Microfluidic-assisted preparation of PLGA nanoparticles for drug delivery purposes: experimental study and computational fluid dynamic simulation
title_fullStr Microfluidic-assisted preparation of PLGA nanoparticles for drug delivery purposes: experimental study and computational fluid dynamic simulation
title_full_unstemmed Microfluidic-assisted preparation of PLGA nanoparticles for drug delivery purposes: experimental study and computational fluid dynamic simulation
title_short Microfluidic-assisted preparation of PLGA nanoparticles for drug delivery purposes: experimental study and computational fluid dynamic simulation
title_sort microfluidic assisted preparation of plga nanoparticles for drug delivery purposes experimental study and computational fluid dynamic simulation
topic computational fluid dynamic; microfluidics; nanoparticles; nanoprecipitation; polylactic-co- glycolicacid.
url http://www.rpsjournal.net/article.asp?issn=1735-5362;year=2019;volume=14;issue=5;spage=459;epage=470;aulast=Shokoohinia
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AT komailsadrjavadi microfluidicassistedpreparationofplgananoparticlesfordrugdeliverypurposesexperimentalstudyandcomputationalfluiddynamicsimulation
AT monaakbari microfluidicassistedpreparationofplgananoparticlesfordrugdeliverypurposesexperimentalstudyandcomputationalfluiddynamicsimulation
AT masoudrahimi microfluidicassistedpreparationofplgananoparticlesfordrugdeliverypurposesexperimentalstudyandcomputationalfluiddynamicsimulation
AT salarkhaledian microfluidicassistedpreparationofplgananoparticlesfordrugdeliverypurposesexperimentalstudyandcomputationalfluiddynamicsimulation
AT alifattahi microfluidicassistedpreparationofplgananoparticlesfordrugdeliverypurposesexperimentalstudyandcomputationalfluiddynamicsimulation