Cytokine mRNA Expression Profile in Target Organs of IFNAR (-/-) Mice Infected with African Horse Sickness Virus
African horse sickness (AHS) is a highly severe disease caused by a viral etiological agent, African horse sickness virus (AHSV). It is endemic in sub-Saharan Africa, while sporadic outbreaks have occurred in North Africa, Asia, and Europe, with the most recent cases in Thailand. AHSV transmission b...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/25/4/2065 |
| _version_ | 1797298013600743424 |
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| author | Eva Calvo-Pinilla Luis Jiménez-Cabello Sergio Utrilla-Trigo Miguel Illescas-Amo Javier Ortego |
| author_facet | Eva Calvo-Pinilla Luis Jiménez-Cabello Sergio Utrilla-Trigo Miguel Illescas-Amo Javier Ortego |
| author_sort | Eva Calvo-Pinilla |
| collection | DOAJ |
| description | African horse sickness (AHS) is a highly severe disease caused by a viral etiological agent, African horse sickness virus (AHSV). It is endemic in sub-Saharan Africa, while sporadic outbreaks have occurred in North Africa, Asia, and Europe, with the most recent cases in Thailand. AHSV transmission between equines occurs primarily by biting midges of the genus <i>Culicoides</i>, especially <i>C. imicola</i>, with a wide distribution globally. As research in horses is highly restricted due to a variety of factors, small laboratory animal models that reproduce clinical signs and pathology observed in natural infection of AHSV are highly needed. Here, we investigated the expression profile of several pro-inflammatory cytokines in target organs and serum of IFNAR (-/-) mice, to continue characterizing this established animal model and to go deep into the innate immune responses that are still needed. |
| first_indexed | 2024-03-07T22:29:48Z |
| format | Article |
| id | doaj.art-827354d500dd405db3d92a414938236d |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-07T22:29:48Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-827354d500dd405db3d92a414938236d2024-02-23T15:19:36ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672024-02-01254206510.3390/ijms25042065Cytokine mRNA Expression Profile in Target Organs of IFNAR (-/-) Mice Infected with African Horse Sickness VirusEva Calvo-Pinilla0Luis Jiménez-Cabello1Sergio Utrilla-Trigo2Miguel Illescas-Amo3Javier Ortego4Centro de Investigación en Sanidad Animal (CISA), Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, Consejo Superior de Investigaciones Científicas (INIA-CSIC), 28130 Valdeolmos, SpainCentro de Investigación en Sanidad Animal (CISA), Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, Consejo Superior de Investigaciones Científicas (INIA-CSIC), 28130 Valdeolmos, SpainCentro de Investigación en Sanidad Animal (CISA), Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, Consejo Superior de Investigaciones Científicas (INIA-CSIC), 28130 Valdeolmos, SpainCentro de Investigación en Sanidad Animal (CISA), Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, Consejo Superior de Investigaciones Científicas (INIA-CSIC), 28130 Valdeolmos, SpainCentro de Investigación en Sanidad Animal (CISA), Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, Consejo Superior de Investigaciones Científicas (INIA-CSIC), 28130 Valdeolmos, SpainAfrican horse sickness (AHS) is a highly severe disease caused by a viral etiological agent, African horse sickness virus (AHSV). It is endemic in sub-Saharan Africa, while sporadic outbreaks have occurred in North Africa, Asia, and Europe, with the most recent cases in Thailand. AHSV transmission between equines occurs primarily by biting midges of the genus <i>Culicoides</i>, especially <i>C. imicola</i>, with a wide distribution globally. As research in horses is highly restricted due to a variety of factors, small laboratory animal models that reproduce clinical signs and pathology observed in natural infection of AHSV are highly needed. Here, we investigated the expression profile of several pro-inflammatory cytokines in target organs and serum of IFNAR (-/-) mice, to continue characterizing this established animal model and to go deep into the innate immune responses that are still needed.https://www.mdpi.com/1422-0067/25/4/2065AHSVpro-inflammatory cytokinesinflammationcytokine stormIFNAR (-/-) mouseequine |
| spellingShingle | Eva Calvo-Pinilla Luis Jiménez-Cabello Sergio Utrilla-Trigo Miguel Illescas-Amo Javier Ortego Cytokine mRNA Expression Profile in Target Organs of IFNAR (-/-) Mice Infected with African Horse Sickness Virus International Journal of Molecular Sciences AHSV pro-inflammatory cytokines inflammation cytokine storm IFNAR (-/-) mouse equine |
| title | Cytokine mRNA Expression Profile in Target Organs of IFNAR (-/-) Mice Infected with African Horse Sickness Virus |
| title_full | Cytokine mRNA Expression Profile in Target Organs of IFNAR (-/-) Mice Infected with African Horse Sickness Virus |
| title_fullStr | Cytokine mRNA Expression Profile in Target Organs of IFNAR (-/-) Mice Infected with African Horse Sickness Virus |
| title_full_unstemmed | Cytokine mRNA Expression Profile in Target Organs of IFNAR (-/-) Mice Infected with African Horse Sickness Virus |
| title_short | Cytokine mRNA Expression Profile in Target Organs of IFNAR (-/-) Mice Infected with African Horse Sickness Virus |
| title_sort | cytokine mrna expression profile in target organs of ifnar mice infected with african horse sickness virus |
| topic | AHSV pro-inflammatory cytokines inflammation cytokine storm IFNAR (-/-) mouse equine |
| url | https://www.mdpi.com/1422-0067/25/4/2065 |
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