Interactions of antiretroviral drugs with the SLC22A1 (OCT1) drug transporter

Interactions of antiretroviral drugs with the SLC22A1 (OCT1) drug transporter

The SLC22A1 influx transporter is expressed on the basolateral membrane of hepatocytes and is involved in the excretion of numerous cations. Inhibition of SLC22A1 by several antiretrovirals, such as the protease inhibitor darunavir, has not previously been determined. In order to better understand a...

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Bibliographic Details
Main Authors: Darren eMoss, Neill eLiptrott, Marco eSiccardi, Andrew eOwen
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-04-01
Series:Frontiers in Pharmacology
Subjects:
HIV
efavirenz
antiretrovirals
Darunavir
OCT1
SLC22A1
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00078/full

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