Insights Into Mechanisms of Antimicrobial Photodynamic Action Toward Biofilms Using Phenalen-1-One Derivatives as Photosensitizers

Insights Into Mechanisms of Antimicrobial Photodynamic Action Toward Biofilms Using Phenalen-1-One Derivatives as Photosensitizers

IntroductionIn view of increasing resistance against antibiotics and antiseptics, antimicrobial photodynamic therapy (aPDT) may be a promising approach for use in dentistry. The aim of this study was to investigate the mechanism of action of aPDT with the phenalene-1-one derivatives SAPYR and SA-PN-...

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Bibliographic Details
Main Authors: Denise Muehler, Christina M. Rupp, Sercan Keceli, Christoph Brochhausen, Heiko Siegmund, Tim Maisch, Karl-Anton Hiller, Wolfgang Buchalla, Fabian Cieplik
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Microbiology
Subjects:
biofilm
antimicrobial photodynamic therapy
SAPYR
chlorhexidine
reactive oxygen species
phenalen-1-one
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2020.589364/full

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