Detection of New Translocation in Infant Twins with Concordant ALL and Discordant Outcome
About 2–5% of acute lymphoblastic leukemia (ALL) cases in pediatric patients are infants with an unfavorable prognosis because of high relapse probability. Early detection of the disease is, therefore, very important. Despite the fact that leukemia in twins occurs rarely, more attention has been pai...
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| Format: | Article |
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MDPI AG
2020-12-01
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| Series: | Pediatric Reports |
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| Online Access: | https://www.mdpi.com/2036-7503/13/1/2 |
| _version_ | 1797543575246864384 |
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| author | Golamreza Bahoush Maryam Vafapour Roxana Kariminejad |
| author_facet | Golamreza Bahoush Maryam Vafapour Roxana Kariminejad |
| author_sort | Golamreza Bahoush |
| collection | DOAJ |
| description | About 2–5% of acute lymphoblastic leukemia (ALL) cases in pediatric patients are infants with an unfavorable prognosis because of high relapse probability. Early detection of the disease is, therefore, very important. Despite the fact that leukemia in twins occurs rarely, more attention has been paid to it in genetic studies. In the present study, through cytogenetic testing, a special case of concordant ALL in monozygotic twins was presented with different outcomes. In spite of an acceptable initial consequence to medical treatment in twins, in another brother (Twin B), early relapse was observed. In the cytogenetic study, both twins expressed <i>t (4; 11) (q21; q23)</i> while twin A expressed <i>t (2; 7) (p10; q10).</i> No cases have previously reported this mutation. Whether this translocation has a protective role for leukemia with mixed-lineage leukemia (MLL) gene rearrangement is still unclear. The difference in the translocation identified in the identical twins is also subject to further investigations. |
| first_indexed | 2024-03-10T13:47:35Z |
| format | Article |
| id | doaj.art-827553cc329f41dc82ff627f7a68775e |
| institution | Directory Open Access Journal |
| issn | 2036-7503 |
| language | English |
| last_indexed | 2024-03-10T13:47:35Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pediatric Reports |
| spelling | doaj.art-827553cc329f41dc82ff627f7a68775e2023-11-21T02:30:52ZengMDPI AGPediatric Reports2036-75032020-12-0113191410.3390/pediatric13010002Detection of New Translocation in Infant Twins with Concordant ALL and Discordant OutcomeGolamreza Bahoush0Maryam Vafapour1Roxana Kariminejad2Ali-Asghar Children Hospital, Faculty of Medicine, Iran University of Medical Sciences, Tehran 16766-19198, IranAli-Asghar Children Hospital, Faculty of Medicine, Iran University of Medical Sciences, Tehran 16766-19198, IranCytogenetic Division, Kariminejad-Najmabadi Pathology & Genetics Center, Tehran 14667-13713, IranAbout 2–5% of acute lymphoblastic leukemia (ALL) cases in pediatric patients are infants with an unfavorable prognosis because of high relapse probability. Early detection of the disease is, therefore, very important. Despite the fact that leukemia in twins occurs rarely, more attention has been paid to it in genetic studies. In the present study, through cytogenetic testing, a special case of concordant ALL in monozygotic twins was presented with different outcomes. In spite of an acceptable initial consequence to medical treatment in twins, in another brother (Twin B), early relapse was observed. In the cytogenetic study, both twins expressed <i>t (4; 11) (q21; q23)</i> while twin A expressed <i>t (2; 7) (p10; q10).</i> No cases have previously reported this mutation. Whether this translocation has a protective role for leukemia with mixed-lineage leukemia (MLL) gene rearrangement is still unclear. The difference in the translocation identified in the identical twins is also subject to further investigations.https://www.mdpi.com/2036-7503/13/1/2acute lymphoblastic leukemia (ALL)monozygotic twinstranslocationMLL rearrangement |
| spellingShingle | Golamreza Bahoush Maryam Vafapour Roxana Kariminejad Detection of New Translocation in Infant Twins with Concordant ALL and Discordant Outcome Pediatric Reports acute lymphoblastic leukemia (ALL) monozygotic twins translocation MLL rearrangement |
| title | Detection of New Translocation in Infant Twins with Concordant ALL and Discordant Outcome |
| title_full | Detection of New Translocation in Infant Twins with Concordant ALL and Discordant Outcome |
| title_fullStr | Detection of New Translocation in Infant Twins with Concordant ALL and Discordant Outcome |
| title_full_unstemmed | Detection of New Translocation in Infant Twins with Concordant ALL and Discordant Outcome |
| title_short | Detection of New Translocation in Infant Twins with Concordant ALL and Discordant Outcome |
| title_sort | detection of new translocation in infant twins with concordant all and discordant outcome |
| topic | acute lymphoblastic leukemia (ALL) monozygotic twins translocation MLL rearrangement |
| url | https://www.mdpi.com/2036-7503/13/1/2 |
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