Human dendritic cell activation induced by a permannosylated dendron containing an antigenic GM3-lactone mimetic
Vaccination strategies based on dendritic cells (DCs) armed with specific tumor antigens have been widely exploited due the properties of these immune cells in coordinating an innate and adaptive response. Here, we describe the convergent synthesis of the bifunctional multivalent glycodendron 5, whi...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Beilstein-Institut
2014-06-01
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| Series: | Beilstein Journal of Organic Chemistry |
| Subjects: | |
| Online Access: | https://doi.org/10.3762/bjoc.10.133 |
| _version_ | 1818460047647178752 |
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| author | Renato Ribeiro-Viana Elena Bonechi Javier Rojo Clara Ballerini Giuseppina Comito Barbara Richichi Cristina Nativi |
| author_facet | Renato Ribeiro-Viana Elena Bonechi Javier Rojo Clara Ballerini Giuseppina Comito Barbara Richichi Cristina Nativi |
| author_sort | Renato Ribeiro-Viana |
| collection | DOAJ |
| description | Vaccination strategies based on dendritic cells (DCs) armed with specific tumor antigens have been widely exploited due the properties of these immune cells in coordinating an innate and adaptive response. Here, we describe the convergent synthesis of the bifunctional multivalent glycodendron 5, which contains nine residues of mannose for DC targeting and one residue of an immunogenic mimetic of a carbohydrate melanoma associated antigen. The immunological assays demonstrated that the glycodendron 5 is able to induce human immature DC activation in terms of a phenotype expression of co-stimulatory molecules expression and MHCII. Furthermore, DCs activated by the glycodendron 5 stimulate T lymphocytes to proliferate in a mixed lymphocytes reaction (MLR). |
| first_indexed | 2024-12-14T23:24:02Z |
| format | Article |
| id | doaj.art-82774213c0b14678a9dff4fcc0567609 |
| institution | Directory Open Access Journal |
| issn | 1860-5397 |
| language | English |
| last_indexed | 2024-12-14T23:24:02Z |
| publishDate | 2014-06-01 |
| publisher | Beilstein-Institut |
| record_format | Article |
| series | Beilstein Journal of Organic Chemistry |
| spelling | doaj.art-82774213c0b14678a9dff4fcc05676092022-12-21T22:43:51ZengBeilstein-InstitutBeilstein Journal of Organic Chemistry1860-53972014-06-011011317132410.3762/bjoc.10.1331860-5397-10-133Human dendritic cell activation induced by a permannosylated dendron containing an antigenic GM3-lactone mimeticRenato Ribeiro-Viana0Elena Bonechi1Javier Rojo2Clara Ballerini3Giuseppina Comito4Barbara Richichi5Cristina Nativi6Glycosystems Laboratory, Instituto de Investigaciones Químicas (IIQ), CSIC – Universidad de Sevilla, Américo Vespucio 49, 41092 Sevilla, SpainDepartment of NEUROFARBA, University of Florence, Viale Pieraccini 6, 50134 Firenze, ItalyGlycosystems Laboratory, Instituto de Investigaciones Químicas (IIQ), CSIC – Universidad de Sevilla, Américo Vespucio 49, 41092 Sevilla, SpainDepartment of NEUROFARBA, University of Florence, Viale Pieraccini 6, 50134 Firenze, ItalyDepartment of Biochemical Science, University of Florence, Viale Morgagni 50, 50134 Florence, ItalyDepartment of Chemistry, University of Florence, Via della Lastruccia 13, 50019 Sesto Fiorentino (FI), ItalyDepartment of Chemistry, University of Florence, Via della Lastruccia 13, 50019 Sesto Fiorentino (FI), ItalyVaccination strategies based on dendritic cells (DCs) armed with specific tumor antigens have been widely exploited due the properties of these immune cells in coordinating an innate and adaptive response. Here, we describe the convergent synthesis of the bifunctional multivalent glycodendron 5, which contains nine residues of mannose for DC targeting and one residue of an immunogenic mimetic of a carbohydrate melanoma associated antigen. The immunological assays demonstrated that the glycodendron 5 is able to induce human immature DC activation in terms of a phenotype expression of co-stimulatory molecules expression and MHCII. Furthermore, DCs activated by the glycodendron 5 stimulate T lymphocytes to proliferate in a mixed lymphocytes reaction (MLR).https://doi.org/10.3762/bjoc.10.133cancer immunotherapyDC-SIGNDC targetingglycodendronGM3-lactone mimeticmultivalent glycosystemsmultivalent interactions |
| spellingShingle | Renato Ribeiro-Viana Elena Bonechi Javier Rojo Clara Ballerini Giuseppina Comito Barbara Richichi Cristina Nativi Human dendritic cell activation induced by a permannosylated dendron containing an antigenic GM3-lactone mimetic Beilstein Journal of Organic Chemistry cancer immunotherapy DC-SIGN DC targeting glycodendron GM3-lactone mimetic multivalent glycosystems multivalent interactions |
| title | Human dendritic cell activation induced by a permannosylated dendron containing an antigenic GM3-lactone mimetic |
| title_full | Human dendritic cell activation induced by a permannosylated dendron containing an antigenic GM3-lactone mimetic |
| title_fullStr | Human dendritic cell activation induced by a permannosylated dendron containing an antigenic GM3-lactone mimetic |
| title_full_unstemmed | Human dendritic cell activation induced by a permannosylated dendron containing an antigenic GM3-lactone mimetic |
| title_short | Human dendritic cell activation induced by a permannosylated dendron containing an antigenic GM3-lactone mimetic |
| title_sort | human dendritic cell activation induced by a permannosylated dendron containing an antigenic gm3 lactone mimetic |
| topic | cancer immunotherapy DC-SIGN DC targeting glycodendron GM3-lactone mimetic multivalent glycosystems multivalent interactions |
| url | https://doi.org/10.3762/bjoc.10.133 |
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