Human dendritic cell activation induced by a permannosylated dendron containing an antigenic GM3-lactone mimetic

Human dendritic cell activation induced by a permannosylated dendron containing an antigenic GM3-lactone mimetic

Vaccination strategies based on dendritic cells (DCs) armed with specific tumor antigens have been widely exploited due the properties of these immune cells in coordinating an innate and adaptive response. Here, we describe the convergent synthesis of the bifunctional multivalent glycodendron 5, whi...

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Bibliographic Details
Main Authors: Renato Ribeiro-Viana, Elena Bonechi, Javier Rojo, Clara Ballerini, Giuseppina Comito, Barbara Richichi, Cristina Nativi
Format: Article
Language:English
Published: Beilstein-Institut 2014-06-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
cancer immunotherapy
DC-SIGN
DC targeting
glycodendron
GM3-lactone mimetic
multivalent glycosystems
multivalent interactions
Online Access:https://doi.org/10.3762/bjoc.10.133

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