The Effect of a Virtual Reality-Based Intervention Program on Cognition in Older Adults with Mild Cognitive Impairment: A Randomized Control Trial
This study aimed to investigate the association between a virtual reality (VR) intervention program and cognitive, brain and physical functions in high-risk older adults. In a randomized controlled trial, we enrolled 68 individuals with mild cognitive impairment (MCI). The MCI diagnosis was based on...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-04-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/9/5/1283 |
| _version_ | 1797569349520719872 |
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| author | Ngeemasara Thapa Hye Jin Park Ja-Gyeong Yang Haeun Son Minwoo Jang Jihyeon Lee Seung Wan Kang Kyung Won Park Hyuntae Park |
| author_facet | Ngeemasara Thapa Hye Jin Park Ja-Gyeong Yang Haeun Son Minwoo Jang Jihyeon Lee Seung Wan Kang Kyung Won Park Hyuntae Park |
| author_sort | Ngeemasara Thapa |
| collection | DOAJ |
| description | This study aimed to investigate the association between a virtual reality (VR) intervention program and cognitive, brain and physical functions in high-risk older adults. In a randomized controlled trial, we enrolled 68 individuals with mild cognitive impairment (MCI). The MCI diagnosis was based on medical evaluations through a clinical interview conducted by a dementia specialist. Cognitive assessments were performed by neuropsychologists according to standardized methods, including the Mini-Mental State Examination (MMSE) and frontal cognitive function: trail making test (TMT) A & B, and symbol digit substitute test (SDST). Resting state electroencephalogram (EEG) was measured in eyes open and eyes closed conditions for 5 minutes each, with a 19-channel wireless EEG device. The VR intervention program (3 times/week, 100 min each session) comprised four types of VR game-based content to improve the attention, memory and processing speed. Analysis of the subjects for group–time interactions revealed that the intervention group exhibited a significantly improved executive function and brain function at the resting state. Additionally, gait speed and mobility were also significantly improved between and after the follow-up. The VR-based training program improved cognitive and physical function in patients with MCI relative to controls. Encouraging patients to perform VR and game-based training may be beneficial to prevent cognitive decline. |
| first_indexed | 2024-03-10T20:09:35Z |
| format | Article |
| id | doaj.art-8277a62911ea46e7be1703ad5a601eea |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T20:09:35Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-8277a62911ea46e7be1703ad5a601eea2023-11-19T23:01:17ZengMDPI AGJournal of Clinical Medicine2077-03832020-04-0195128310.3390/jcm9051283The Effect of a Virtual Reality-Based Intervention Program on Cognition in Older Adults with Mild Cognitive Impairment: A Randomized Control TrialNgeemasara Thapa0Hye Jin Park1Ja-Gyeong Yang2Haeun Son3Minwoo Jang4Jihyeon Lee5Seung Wan Kang6Kyung Won Park7Hyuntae Park8Department of Health Sciences, Graduate School, Dong-A University, Busan 49315, KoreaDepartment of Health Sciences, Graduate School, Dong-A University, Busan 49315, KoreaDepartment of Health Sciences, Graduate School, Dong-A University, Busan 49315, KoreaDepartment of Health Sciences, Graduate School, Dong-A University, Busan 49315, KoreaDepartment of Health Sciences, Graduate School, Dong-A University, Busan 49315, KoreaDepartment of Health Sciences, Graduate School, Dong-A University, Busan 49315, KoreaData Center for Korean EEG, College of Nursing, Seoul National University, Seoul 03080, KoreaDepartment of Neurology, Dong-A University College of Medicine, Busan 49201, KoreaDepartment of Health Sciences, Graduate School, Dong-A University, Busan 49315, KoreaThis study aimed to investigate the association between a virtual reality (VR) intervention program and cognitive, brain and physical functions in high-risk older adults. In a randomized controlled trial, we enrolled 68 individuals with mild cognitive impairment (MCI). The MCI diagnosis was based on medical evaluations through a clinical interview conducted by a dementia specialist. Cognitive assessments were performed by neuropsychologists according to standardized methods, including the Mini-Mental State Examination (MMSE) and frontal cognitive function: trail making test (TMT) A & B, and symbol digit substitute test (SDST). Resting state electroencephalogram (EEG) was measured in eyes open and eyes closed conditions for 5 minutes each, with a 19-channel wireless EEG device. The VR intervention program (3 times/week, 100 min each session) comprised four types of VR game-based content to improve the attention, memory and processing speed. Analysis of the subjects for group–time interactions revealed that the intervention group exhibited a significantly improved executive function and brain function at the resting state. Additionally, gait speed and mobility were also significantly improved between and after the follow-up. The VR-based training program improved cognitive and physical function in patients with MCI relative to controls. Encouraging patients to perform VR and game-based training may be beneficial to prevent cognitive decline.https://www.mdpi.com/2077-0383/9/5/1283virtual realitydementiamild cognitive impairmentelectroencephalogram |
| spellingShingle | Ngeemasara Thapa Hye Jin Park Ja-Gyeong Yang Haeun Son Minwoo Jang Jihyeon Lee Seung Wan Kang Kyung Won Park Hyuntae Park The Effect of a Virtual Reality-Based Intervention Program on Cognition in Older Adults with Mild Cognitive Impairment: A Randomized Control Trial Journal of Clinical Medicine virtual reality dementia mild cognitive impairment electroencephalogram |
| title | The Effect of a Virtual Reality-Based Intervention Program on Cognition in Older Adults with Mild Cognitive Impairment: A Randomized Control Trial |
| title_full | The Effect of a Virtual Reality-Based Intervention Program on Cognition in Older Adults with Mild Cognitive Impairment: A Randomized Control Trial |
| title_fullStr | The Effect of a Virtual Reality-Based Intervention Program on Cognition in Older Adults with Mild Cognitive Impairment: A Randomized Control Trial |
| title_full_unstemmed | The Effect of a Virtual Reality-Based Intervention Program on Cognition in Older Adults with Mild Cognitive Impairment: A Randomized Control Trial |
| title_short | The Effect of a Virtual Reality-Based Intervention Program on Cognition in Older Adults with Mild Cognitive Impairment: A Randomized Control Trial |
| title_sort | effect of a virtual reality based intervention program on cognition in older adults with mild cognitive impairment a randomized control trial |
| topic | virtual reality dementia mild cognitive impairment electroencephalogram |
| url | https://www.mdpi.com/2077-0383/9/5/1283 |
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