The Antibacterial Effects of Supermolecular Nano-Carriers by Combination of Silver and Photodynamic Therapy
The over-use of antibiotics has promoted multidrug resistance and decreased the efficacy of antibiotic therapy. Thus, it is still in great need to develop efficient treatment strategies to combat the bacteria infection. The antimicrobial photodynamic therapy (aPDT) and silver nanoparticles have been...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-04-01
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| Series: | Frontiers in Chemistry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fchem.2021.666408/full |
| _version_ | 1818429946762100736 |
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| author | Gui-ning Feng Xiao-tao Huang Xin-lin Jiang Ting-wei Deng Qiu-xia Li Jie-xia Li Qian-ni Wu Song-pei Li Xian-qiang Sun Yu-gang Huang Ai-ping Qin Lu Liang Ji-jun Fu |
| author_facet | Gui-ning Feng Xiao-tao Huang Xin-lin Jiang Ting-wei Deng Qiu-xia Li Jie-xia Li Qian-ni Wu Song-pei Li Xian-qiang Sun Yu-gang Huang Ai-ping Qin Lu Liang Ji-jun Fu |
| author_sort | Gui-ning Feng |
| collection | DOAJ |
| description | The over-use of antibiotics has promoted multidrug resistance and decreased the efficacy of antibiotic therapy. Thus, it is still in great need to develop efficient treatment strategies to combat the bacteria infection. The antimicrobial photodynamic therapy (aPDT) and silver nanoparticles have been emerged as effective antibacterial methods. However, the silver therapy may induce serious damages to human cells at high concentrations and, the bare silver nanoparticles may rapidly aggregate, which would reduce the antibacterial efficacy. The encapsulation of sliver by nano-carrier is a promising way to avoid its aggregation and facilitates the co-delivery of drugs for combination therapy, which does not require high concentration of sliver to exert antibacterial efficacy. This work constructed a self-assembled supermolecular nano-carrier consisting of the photosensitizers (PSs), the anti-inflammatory agent and silver. The synthesized supermolecular nano-carrier produced reactive oxygen species (ROS) under the exposure of 620-nm laser. It exhibited satisfying biocompatibility in L02 cells. And, this nano-carrier showed excellent antibacterial efficacy in Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) as indicated by bacterial growth and colony formation. Its antibacterial performance is further validated by the bacteria morphology through the scanning electron microscope (SEM), showing severely damaged structures of bacteria. To summary, the supermolecular nano-carrier TCPP-MTX-Ag-NP combining the therapeutic effects of ROS and silver may serve as a novel strategy of treatment for bacterial infection. |
| first_indexed | 2024-12-14T15:25:36Z |
| format | Article |
| id | doaj.art-82780d0a54f94a7fb3bdc321c027d103 |
| institution | Directory Open Access Journal |
| issn | 2296-2646 |
| language | English |
| last_indexed | 2024-12-14T15:25:36Z |
| publishDate | 2021-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Chemistry |
| spelling | doaj.art-82780d0a54f94a7fb3bdc321c027d1032022-12-21T22:56:02ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462021-04-01910.3389/fchem.2021.666408666408The Antibacterial Effects of Supermolecular Nano-Carriers by Combination of Silver and Photodynamic TherapyGui-ning Feng0Xiao-tao Huang1Xin-lin Jiang2Ting-wei Deng3Qiu-xia Li4Jie-xia Li5Qian-ni Wu6Song-pei Li7Xian-qiang Sun8Yu-gang Huang9Ai-ping Qin10Lu Liang11Ji-jun Fu12The Key Laboratory of Molecular Target & Clinical Pharmacology, School of Pharmaceutical Sciences, The First Affiliated Hospital of Guangzhou Medical University and the Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, ChinaThe Key Laboratory of Molecular Target & Clinical Pharmacology, School of Pharmaceutical Sciences, The First Affiliated Hospital of Guangzhou Medical University and the Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, ChinaThe Key Laboratory of Molecular Target & Clinical Pharmacology, School of Pharmaceutical Sciences, The First Affiliated Hospital of Guangzhou Medical University and the Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, ChinaSchool of Pharmaceutical Sciences, Shenzhen University, Shenzhen, ChinaThe Key Laboratory of Molecular Target & Clinical Pharmacology, School of Pharmaceutical Sciences, The First Affiliated Hospital of Guangzhou Medical University and the Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, ChinaThe Key Laboratory of Molecular Target & Clinical Pharmacology, School of Pharmaceutical Sciences, The First Affiliated Hospital of Guangzhou Medical University and the Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, ChinaThe Key Laboratory of Molecular Target & Clinical Pharmacology, School of Pharmaceutical Sciences, The First Affiliated Hospital of Guangzhou Medical University and the Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, ChinaThe Key Laboratory of Molecular Target & Clinical Pharmacology, School of Pharmaceutical Sciences, The First Affiliated Hospital of Guangzhou Medical University and the Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, ChinaThe Key Laboratory of Molecular Target & Clinical Pharmacology, School of Pharmaceutical Sciences, The First Affiliated Hospital of Guangzhou Medical University and the Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, ChinaThe Key Laboratory of Molecular Target & Clinical Pharmacology, School of Pharmaceutical Sciences, The First Affiliated Hospital of Guangzhou Medical University and the Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, ChinaThe Key Laboratory of Molecular Target & Clinical Pharmacology, School of Pharmaceutical Sciences, The First Affiliated Hospital of Guangzhou Medical University and the Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, ChinaThe Key Laboratory of Molecular Target & Clinical Pharmacology, School of Pharmaceutical Sciences, The First Affiliated Hospital of Guangzhou Medical University and the Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, ChinaThe Key Laboratory of Molecular Target & Clinical Pharmacology, School of Pharmaceutical Sciences, The First Affiliated Hospital of Guangzhou Medical University and the Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, ChinaThe over-use of antibiotics has promoted multidrug resistance and decreased the efficacy of antibiotic therapy. Thus, it is still in great need to develop efficient treatment strategies to combat the bacteria infection. The antimicrobial photodynamic therapy (aPDT) and silver nanoparticles have been emerged as effective antibacterial methods. However, the silver therapy may induce serious damages to human cells at high concentrations and, the bare silver nanoparticles may rapidly aggregate, which would reduce the antibacterial efficacy. The encapsulation of sliver by nano-carrier is a promising way to avoid its aggregation and facilitates the co-delivery of drugs for combination therapy, which does not require high concentration of sliver to exert antibacterial efficacy. This work constructed a self-assembled supermolecular nano-carrier consisting of the photosensitizers (PSs), the anti-inflammatory agent and silver. The synthesized supermolecular nano-carrier produced reactive oxygen species (ROS) under the exposure of 620-nm laser. It exhibited satisfying biocompatibility in L02 cells. And, this nano-carrier showed excellent antibacterial efficacy in Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) as indicated by bacterial growth and colony formation. Its antibacterial performance is further validated by the bacteria morphology through the scanning electron microscope (SEM), showing severely damaged structures of bacteria. To summary, the supermolecular nano-carrier TCPP-MTX-Ag-NP combining the therapeutic effects of ROS and silver may serve as a novel strategy of treatment for bacterial infection.https://www.frontiersin.org/articles/10.3389/fchem.2021.666408/fullbacteriaantimicrobial photodynamic therapysilversupermolecular nano-carriersynergistic efficacy |
| spellingShingle | Gui-ning Feng Xiao-tao Huang Xin-lin Jiang Ting-wei Deng Qiu-xia Li Jie-xia Li Qian-ni Wu Song-pei Li Xian-qiang Sun Yu-gang Huang Ai-ping Qin Lu Liang Ji-jun Fu The Antibacterial Effects of Supermolecular Nano-Carriers by Combination of Silver and Photodynamic Therapy Frontiers in Chemistry bacteria antimicrobial photodynamic therapy silver supermolecular nano-carrier synergistic efficacy |
| title | The Antibacterial Effects of Supermolecular Nano-Carriers by Combination of Silver and Photodynamic Therapy |
| title_full | The Antibacterial Effects of Supermolecular Nano-Carriers by Combination of Silver and Photodynamic Therapy |
| title_fullStr | The Antibacterial Effects of Supermolecular Nano-Carriers by Combination of Silver and Photodynamic Therapy |
| title_full_unstemmed | The Antibacterial Effects of Supermolecular Nano-Carriers by Combination of Silver and Photodynamic Therapy |
| title_short | The Antibacterial Effects of Supermolecular Nano-Carriers by Combination of Silver and Photodynamic Therapy |
| title_sort | antibacterial effects of supermolecular nano carriers by combination of silver and photodynamic therapy |
| topic | bacteria antimicrobial photodynamic therapy silver supermolecular nano-carrier synergistic efficacy |
| url | https://www.frontiersin.org/articles/10.3389/fchem.2021.666408/full |
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