Reduced Endothelin-2 and Hypoxic Signaling Pathways in Granulosa-Lutein Cells of PCOS Women

Reduced Endothelin-2 and Hypoxic Signaling Pathways in Granulosa-Lutein Cells of PCOS Women

Granulosa-lutein cells (GLCs) from PCOS women display reduced <i>HIF-1α</i> and <i>EDN2</i> levels, suggesting their role in PCOS etiology. Here, we investigated the mechanisms involved in aberrant <i>EDN2</i> expression in PCOS, and its association with <i>...

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Bibliographic Details
Main Authors: Magdalena Szymanska, Ketan Shrestha, Eliezer Girsh, Avi Harlev, Iris Eisenberg, Tal Imbar, Rina Meidan
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:International Journal of Molecular Sciences
Subjects:
miR-210
<i>VEGFA</i>
<i>HIF-1α</i>
ovulation
corpus luteum
Online Access:https://www.mdpi.com/1422-0067/22/15/8216

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