Beyond Antibiotics: Photo/Sonodynamic Approaches for Bacterial Theranostics
Abstract Rapid evolution and propagation of multidrug resistance among bacterial pathogens are outpacing the development of new antibiotics, but antimicrobial photodynamic therapy (aPDT) provides an excellent alternative. This treatment depends on the interaction between light and photoactivated sen...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2020-07-01
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| Series: | Nano-Micro Letters |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1007/s40820-020-00485-3 |
| _version_ | 1818217807708422144 |
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| author | Xin Pang Dengfeng Li Jing Zhu Jingliang Cheng Gang Liu |
| author_facet | Xin Pang Dengfeng Li Jing Zhu Jingliang Cheng Gang Liu |
| author_sort | Xin Pang |
| collection | DOAJ |
| description | Abstract Rapid evolution and propagation of multidrug resistance among bacterial pathogens are outpacing the development of new antibiotics, but antimicrobial photodynamic therapy (aPDT) provides an excellent alternative. This treatment depends on the interaction between light and photoactivated sensitizer to generate reactive oxygen species (ROS), which are highly cytotoxic to induce apoptosis in virtually all microorganisms without resistance concern. When replacing light with low-frequency ultrasonic wave to activate sensitizer, a novel ultrasound-driven treatment emerges as antimicrobial sonodynamic therapy (aSDT). Recent advances in aPDT and aSDT reveal golden opportunities for the management of multidrug resistant bacterial infections, especially in the theranostic application where imaging diagnosis can be accomplished facilely with the inherent optical characteristics of sensitizers, and the generated ROS by aPDT/SDT cause broad-spectrum oxidative damage for sterilization. In this review, we systemically outline the mechanisms, targets, and current progress of aPDT/SDT for bacterial theranostic application. Furthermore, potential limitations and future perspectives are also highlighted. |
| first_indexed | 2024-12-12T07:13:44Z |
| format | Article |
| id | doaj.art-827a6de4343f41559cdab48efdfee050 |
| institution | Directory Open Access Journal |
| issn | 2311-6706 2150-5551 |
| language | English |
| last_indexed | 2024-12-12T07:13:44Z |
| publishDate | 2020-07-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Nano-Micro Letters |
| spelling | doaj.art-827a6de4343f41559cdab48efdfee0502022-12-22T00:33:33ZengSpringerOpenNano-Micro Letters2311-67062150-55512020-07-0112112310.1007/s40820-020-00485-3Beyond Antibiotics: Photo/Sonodynamic Approaches for Bacterial TheranosticsXin Pang0Dengfeng Li1Jing Zhu2Jingliang Cheng3Gang Liu4Henan Key Laboratory of Functional Magnetic Resonance Imaging and Molecular Imaging, Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou UniversityState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics and Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen UniversityHenan Key Laboratory of Functional Magnetic Resonance Imaging and Molecular Imaging, Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou UniversityHenan Key Laboratory of Functional Magnetic Resonance Imaging and Molecular Imaging, Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou UniversityState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics and Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen UniversityAbstract Rapid evolution and propagation of multidrug resistance among bacterial pathogens are outpacing the development of new antibiotics, but antimicrobial photodynamic therapy (aPDT) provides an excellent alternative. This treatment depends on the interaction between light and photoactivated sensitizer to generate reactive oxygen species (ROS), which are highly cytotoxic to induce apoptosis in virtually all microorganisms without resistance concern. When replacing light with low-frequency ultrasonic wave to activate sensitizer, a novel ultrasound-driven treatment emerges as antimicrobial sonodynamic therapy (aSDT). Recent advances in aPDT and aSDT reveal golden opportunities for the management of multidrug resistant bacterial infections, especially in the theranostic application where imaging diagnosis can be accomplished facilely with the inherent optical characteristics of sensitizers, and the generated ROS by aPDT/SDT cause broad-spectrum oxidative damage for sterilization. In this review, we systemically outline the mechanisms, targets, and current progress of aPDT/SDT for bacterial theranostic application. Furthermore, potential limitations and future perspectives are also highlighted.http://link.springer.com/article/10.1007/s40820-020-00485-3Photodynamic therapySonodynamic therapyTheranosticsMultidrug resistantReactive oxygen species |
| spellingShingle | Xin Pang Dengfeng Li Jing Zhu Jingliang Cheng Gang Liu Beyond Antibiotics: Photo/Sonodynamic Approaches for Bacterial Theranostics Nano-Micro Letters Photodynamic therapy Sonodynamic therapy Theranostics Multidrug resistant Reactive oxygen species |
| title | Beyond Antibiotics: Photo/Sonodynamic Approaches for Bacterial Theranostics |
| title_full | Beyond Antibiotics: Photo/Sonodynamic Approaches for Bacterial Theranostics |
| title_fullStr | Beyond Antibiotics: Photo/Sonodynamic Approaches for Bacterial Theranostics |
| title_full_unstemmed | Beyond Antibiotics: Photo/Sonodynamic Approaches for Bacterial Theranostics |
| title_short | Beyond Antibiotics: Photo/Sonodynamic Approaches for Bacterial Theranostics |
| title_sort | beyond antibiotics photo sonodynamic approaches for bacterial theranostics |
| topic | Photodynamic therapy Sonodynamic therapy Theranostics Multidrug resistant Reactive oxygen species |
| url | http://link.springer.com/article/10.1007/s40820-020-00485-3 |
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