Finite Element Analysis Investigate Pulmonary Autograft Root and Leaflet Stresses to Understand Late Durability of Ross Operation
Ross operation might be a valid option for congenital and acquired left ventricular outflow tract disease in selected cases. As the pulmonary autograft is a living substitute for the aortic root that bioinspired the Ross operation, we have created an experimental animal model in which the vital capa...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-08-01
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| Series: | Biomimetics |
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| Online Access: | https://www.mdpi.com/2313-7673/5/3/37 |
| _version_ | 1797560478267867136 |
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| author | Francesco Nappi Antonio Nenna Francesca Lemmo Massimo Chello Juan Carlos Chachques Christophe Acar Domenico Larobina |
| author_facet | Francesco Nappi Antonio Nenna Francesca Lemmo Massimo Chello Juan Carlos Chachques Christophe Acar Domenico Larobina |
| author_sort | Francesco Nappi |
| collection | DOAJ |
| description | Ross operation might be a valid option for congenital and acquired left ventricular outflow tract disease in selected cases. As the pulmonary autograft is a living substitute for the aortic root that bioinspired the Ross operation, we have created an experimental animal model in which the vital capacity of the pulmonary autograft (PA) has been studied during physiological growth. The present study aims to determine any increased stresses in PA root and leaflet compared to the similar components of the native aorta. An animal model and a mathematical analysis using finite element analysis have been used for the purpose of this manuscript. The results of this study advance our understanding of the relative benefits of pulmonary autograft for the management of severe aortic valve disease. However, it launches a warning about the importance of the choice of the length of the conduits as mechanical deformation, and, therefore, potential failure, increases with the length of the segment subjected to stress. Understanding PA root and leaflet stresses is the first step toward understanding PA durability and the regions prone to dilatation, ultimately to refine the best implant technique. |
| first_indexed | 2024-03-10T18:00:09Z |
| format | Article |
| id | doaj.art-827af67b76204a0d9feedc2a79ea37f0 |
| institution | Directory Open Access Journal |
| issn | 2313-7673 |
| language | English |
| last_indexed | 2024-03-10T18:00:09Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomimetics |
| spelling | doaj.art-827af67b76204a0d9feedc2a79ea37f02023-11-20T08:55:35ZengMDPI AGBiomimetics2313-76732020-08-01533710.3390/biomimetics5030037Finite Element Analysis Investigate Pulmonary Autograft Root and Leaflet Stresses to Understand Late Durability of Ross OperationFrancesco Nappi0Antonio Nenna1Francesca Lemmo2Massimo Chello3Juan Carlos Chachques4Christophe Acar5Domenico Larobina6Department of Cardiac Surgery, Centre Cardiologique du Nord de Saint-Denis, 93200 Paris, FranceDepartment of Cardiovascular Surgery, University Campus Bio-Medico of Rome, 00128 Rome, ItalyFaculty of Engineering, University of Turin, 10124 Turin, ItalyDepartment of Cardiovascular Surgery, University Campus Bio-Medico of Rome, 00128 Rome, ItalyDepartment of Cardiovascular Surgery Carpentier Foundation, Pompidou Hospital, University Paris Descartes, 75015 Paris, FranceDepartment of Cardiovascular Surgery, Hopital de la Salpetriere, 75013 Paris, FranceInstitute for Polymers, Composites, and Biomaterials, National Research Council of Italy, 00185 Rome, ItalyRoss operation might be a valid option for congenital and acquired left ventricular outflow tract disease in selected cases. As the pulmonary autograft is a living substitute for the aortic root that bioinspired the Ross operation, we have created an experimental animal model in which the vital capacity of the pulmonary autograft (PA) has been studied during physiological growth. The present study aims to determine any increased stresses in PA root and leaflet compared to the similar components of the native aorta. An animal model and a mathematical analysis using finite element analysis have been used for the purpose of this manuscript. The results of this study advance our understanding of the relative benefits of pulmonary autograft for the management of severe aortic valve disease. However, it launches a warning about the importance of the choice of the length of the conduits as mechanical deformation, and, therefore, potential failure, increases with the length of the segment subjected to stress. Understanding PA root and leaflet stresses is the first step toward understanding PA durability and the regions prone to dilatation, ultimately to refine the best implant technique.https://www.mdpi.com/2313-7673/5/3/37pulmonary autograftbioinspired Ross operationpulmonary autograft expansionpulmonary autograft biomechanical |
| spellingShingle | Francesco Nappi Antonio Nenna Francesca Lemmo Massimo Chello Juan Carlos Chachques Christophe Acar Domenico Larobina Finite Element Analysis Investigate Pulmonary Autograft Root and Leaflet Stresses to Understand Late Durability of Ross Operation Biomimetics pulmonary autograft bioinspired Ross operation pulmonary autograft expansion pulmonary autograft biomechanical |
| title | Finite Element Analysis Investigate Pulmonary Autograft Root and Leaflet Stresses to Understand Late Durability of Ross Operation |
| title_full | Finite Element Analysis Investigate Pulmonary Autograft Root and Leaflet Stresses to Understand Late Durability of Ross Operation |
| title_fullStr | Finite Element Analysis Investigate Pulmonary Autograft Root and Leaflet Stresses to Understand Late Durability of Ross Operation |
| title_full_unstemmed | Finite Element Analysis Investigate Pulmonary Autograft Root and Leaflet Stresses to Understand Late Durability of Ross Operation |
| title_short | Finite Element Analysis Investigate Pulmonary Autograft Root and Leaflet Stresses to Understand Late Durability of Ross Operation |
| title_sort | finite element analysis investigate pulmonary autograft root and leaflet stresses to understand late durability of ross operation |
| topic | pulmonary autograft bioinspired Ross operation pulmonary autograft expansion pulmonary autograft biomechanical |
| url | https://www.mdpi.com/2313-7673/5/3/37 |
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