Animal Models in Allogenic Solid Organ Transplantation
Animal models provide the link between in vitro research and the first in-man application during clinical trials. They provide substantial information in preclinical studies for the assessment of new therapeutic interventions in advance of human clinical trials. However, each model has its advantage...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Transplantology |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2673-3943/2/4/39 |
| _version_ | 1827669202807291904 |
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| author | Nadine Wenzel Rainer Blasczyk Constanca Figueiredo |
| author_facet | Nadine Wenzel Rainer Blasczyk Constanca Figueiredo |
| author_sort | Nadine Wenzel |
| collection | DOAJ |
| description | Animal models provide the link between in vitro research and the first in-man application during clinical trials. They provide substantial information in preclinical studies for the assessment of new therapeutic interventions in advance of human clinical trials. However, each model has its advantages and limitations in the ability to imitate specific pathomechanisms. Therefore, the selection of an animal model for the evaluation of a specific research question or evaluation of a novel therapeutic strategy requires a precise analysis. Transplantation research is a discipline that largely benefits from the use of animal models with mouse and pig models being the most frequently used models in organ transplantation research. A suitable animal model should reflect best the situation in humans, and the researcher should be aware of the similarities as well as the limitations of the chosen model. Small animal models with rats and mice are contributing to the majority of animal experiments with the obvious advantages of these models being easy handling, low costs, and high reproductive rates. However, unfortunately, they often do not translate to clinical use. Large animal models, especially in transplantation medicine, are an important element for establishing preclinical models that do often translate to the clinic. Nevertheless, they can be costly, present increased regulatory requirements, and often are of high ethical concern. Therefore, it is crucial to select the right animal model from which extrapolations and valid conclusions can be obtained and translated into the human situation. This review provides an overview in the models frequently used in organ transplantation research. |
| first_indexed | 2024-03-10T03:58:07Z |
| format | Article |
| id | doaj.art-827c550accfa4c5c8eda70206bfc2eea |
| institution | Directory Open Access Journal |
| issn | 2673-3943 |
| language | English |
| last_indexed | 2024-03-10T03:58:07Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Transplantology |
| spelling | doaj.art-827c550accfa4c5c8eda70206bfc2eea2023-11-23T10:51:24ZengMDPI AGTransplantology2673-39432021-10-012441242410.3390/transplantology2040039Animal Models in Allogenic Solid Organ TransplantationNadine Wenzel0Rainer Blasczyk1Constanca Figueiredo2Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School, 30625 Hannover, GermanyInstitute of Transfusion Medicine and Transplant Engineering, Hannover Medical School, 30625 Hannover, GermanyInstitute of Transfusion Medicine and Transplant Engineering, Hannover Medical School, 30625 Hannover, GermanyAnimal models provide the link between in vitro research and the first in-man application during clinical trials. They provide substantial information in preclinical studies for the assessment of new therapeutic interventions in advance of human clinical trials. However, each model has its advantages and limitations in the ability to imitate specific pathomechanisms. Therefore, the selection of an animal model for the evaluation of a specific research question or evaluation of a novel therapeutic strategy requires a precise analysis. Transplantation research is a discipline that largely benefits from the use of animal models with mouse and pig models being the most frequently used models in organ transplantation research. A suitable animal model should reflect best the situation in humans, and the researcher should be aware of the similarities as well as the limitations of the chosen model. Small animal models with rats and mice are contributing to the majority of animal experiments with the obvious advantages of these models being easy handling, low costs, and high reproductive rates. However, unfortunately, they often do not translate to clinical use. Large animal models, especially in transplantation medicine, are an important element for establishing preclinical models that do often translate to the clinic. Nevertheless, they can be costly, present increased regulatory requirements, and often are of high ethical concern. Therefore, it is crucial to select the right animal model from which extrapolations and valid conclusions can be obtained and translated into the human situation. This review provides an overview in the models frequently used in organ transplantation research.https://www.mdpi.com/2673-3943/2/4/39small animal modellarge animal modelsolid organ transplantation |
| spellingShingle | Nadine Wenzel Rainer Blasczyk Constanca Figueiredo Animal Models in Allogenic Solid Organ Transplantation Transplantology small animal model large animal model solid organ transplantation |
| title | Animal Models in Allogenic Solid Organ Transplantation |
| title_full | Animal Models in Allogenic Solid Organ Transplantation |
| title_fullStr | Animal Models in Allogenic Solid Organ Transplantation |
| title_full_unstemmed | Animal Models in Allogenic Solid Organ Transplantation |
| title_short | Animal Models in Allogenic Solid Organ Transplantation |
| title_sort | animal models in allogenic solid organ transplantation |
| topic | small animal model large animal model solid organ transplantation |
| url | https://www.mdpi.com/2673-3943/2/4/39 |
| work_keys_str_mv | AT nadinewenzel animalmodelsinallogenicsolidorgantransplantation AT rainerblasczyk animalmodelsinallogenicsolidorgantransplantation AT constancafigueiredo animalmodelsinallogenicsolidorgantransplantation |