Evaluation of Prognostic Significance of the International Staging System According to Glomerular Filtration Rate in Newly Diagnosed Multiple Myeloma Patients Eligible for Autologous Stem Cell Transplantation
Objective: The prognosis of multiple myeloma (MM) patients is highly heterogeneous. The aim of this study is to determine the impact of patients' renal functions on the prognostic performance of the International Staging System (ISS). In addition, we aimed to evaluate the results of survival of...
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2021-02-01
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| Series: | Turkish Journal of Hematology |
| Subjects: | |
| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tjh&un=TJH-00344 |
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| author | Rafiye Çiftçiler Hakan Göker Haluk Demiroğlu İbrahim Celalettin Haznedaroğlu Nilgün Sayınalp Salih Aksu Osman Özcebe Yahya Büyükaşık |
| author_facet | Rafiye Çiftçiler Hakan Göker Haluk Demiroğlu İbrahim Celalettin Haznedaroğlu Nilgün Sayınalp Salih Aksu Osman Özcebe Yahya Büyükaşık |
| author_sort | Rafiye Çiftçiler |
| collection | DOAJ |
| description | Objective: The prognosis of multiple myeloma (MM) patients is highly heterogeneous. The aim of this study is to determine the impact of patients' renal functions on the prognostic performance of the International Staging System (ISS). In addition, we aimed to evaluate the results of survival of patients with ISS stages and normal renal functions and those with ISS stages and abnormal renal functions with this study. Materials and Methods: Two hundred and four patients with newly diagnosed MM who received an autologous stem cell transplantation after induction chemotherapy in our tertiary care center between the years of 2001 and 2018 were evaluated. Results: There were 153 (75%) MM patients who had a glomerular filtration rate (GFR) of ≥60 mL/min and 51 (25%) MM patients who had GFR of <60 mL/min at the time of diagnosis in this study. There was a strong correlation between ISS stage and GFR. The ISS stages were higher in patients who had GFR of <60 mL/min than patients who had GFR of ≥60 mL/min (p<0.001). Patients with GFR of <60 mL/min were significantly more prevalent in the ISS III group than ISS I and II (p<0.001). Conclusion: This study showed that the ISS provides significant prognostic information in MM patients with GFR of ≥60 mL/min at diagnosis. However, in patients with impaired renal function at the time of diagnosis, B2-microglobulin may not be a good prognostic indicator since it may be affected by renal dysfunction as well as tumor burden. |
| first_indexed | 2024-04-10T13:06:18Z |
| format | Article |
| id | doaj.art-827f7088dedd472580f9a5a8e21793bf |
| institution | Directory Open Access Journal |
| issn | 1308-5263 |
| language | English |
| last_indexed | 2024-04-10T13:06:18Z |
| publishDate | 2021-02-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Turkish Journal of Hematology |
| spelling | doaj.art-827f7088dedd472580f9a5a8e21793bf2023-02-15T16:12:58ZengGalenos Publishing HouseTurkish Journal of Hematology1308-52632021-02-01381334010.4274/tjh.galenos.2020.2020.0115TJH-00344Evaluation of Prognostic Significance of the International Staging System According to Glomerular Filtration Rate in Newly Diagnosed Multiple Myeloma Patients Eligible for Autologous Stem Cell TransplantationRafiye Çiftçiler0Hakan Göker1Haluk Demiroğlu2İbrahim Celalettin Haznedaroğlu3Nilgün Sayınalp4Salih Aksu5Osman Özcebe6Yahya Büyükaşık7Hacettepe University Faculty of Medicine, Department of Hematology, Ankara, TurkeyHacettepe University Faculty of Medicine, Department of Hematology, Ankara, TurkeyHacettepe University Faculty of Medicine, Department of Hematology, Ankara, TurkeyHacettepe University Faculty of Medicine, Department of Hematology, Ankara, TurkeyHacettepe University Faculty of Medicine, Department of Hematology, Ankara, TurkeyHacettepe University Faculty of Medicine, Department of Hematology, Ankara, TurkeyHacettepe University Faculty of Medicine, Department of Hematology, Ankara, TurkeyHacettepe University Faculty of Medicine, Department of Hematology, Ankara, TurkeyObjective: The prognosis of multiple myeloma (MM) patients is highly heterogeneous. The aim of this study is to determine the impact of patients' renal functions on the prognostic performance of the International Staging System (ISS). In addition, we aimed to evaluate the results of survival of patients with ISS stages and normal renal functions and those with ISS stages and abnormal renal functions with this study. Materials and Methods: Two hundred and four patients with newly diagnosed MM who received an autologous stem cell transplantation after induction chemotherapy in our tertiary care center between the years of 2001 and 2018 were evaluated. Results: There were 153 (75%) MM patients who had a glomerular filtration rate (GFR) of ≥60 mL/min and 51 (25%) MM patients who had GFR of <60 mL/min at the time of diagnosis in this study. There was a strong correlation between ISS stage and GFR. The ISS stages were higher in patients who had GFR of <60 mL/min than patients who had GFR of ≥60 mL/min (p<0.001). Patients with GFR of <60 mL/min were significantly more prevalent in the ISS III group than ISS I and II (p<0.001). Conclusion: This study showed that the ISS provides significant prognostic information in MM patients with GFR of ≥60 mL/min at diagnosis. However, in patients with impaired renal function at the time of diagnosis, B2-microglobulin may not be a good prognostic indicator since it may be affected by renal dysfunction as well as tumor burden.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tjh&un=TJH-00344multiple myelomab2-microglobulininternational staging system |
| spellingShingle | Rafiye Çiftçiler Hakan Göker Haluk Demiroğlu İbrahim Celalettin Haznedaroğlu Nilgün Sayınalp Salih Aksu Osman Özcebe Yahya Büyükaşık Evaluation of Prognostic Significance of the International Staging System According to Glomerular Filtration Rate in Newly Diagnosed Multiple Myeloma Patients Eligible for Autologous Stem Cell Transplantation Turkish Journal of Hematology multiple myeloma b2-microglobulin international staging system |
| title | Evaluation of Prognostic Significance of the International Staging System According to Glomerular Filtration Rate in Newly Diagnosed Multiple Myeloma Patients Eligible for Autologous Stem Cell Transplantation |
| title_full | Evaluation of Prognostic Significance of the International Staging System According to Glomerular Filtration Rate in Newly Diagnosed Multiple Myeloma Patients Eligible for Autologous Stem Cell Transplantation |
| title_fullStr | Evaluation of Prognostic Significance of the International Staging System According to Glomerular Filtration Rate in Newly Diagnosed Multiple Myeloma Patients Eligible for Autologous Stem Cell Transplantation |
| title_full_unstemmed | Evaluation of Prognostic Significance of the International Staging System According to Glomerular Filtration Rate in Newly Diagnosed Multiple Myeloma Patients Eligible for Autologous Stem Cell Transplantation |
| title_short | Evaluation of Prognostic Significance of the International Staging System According to Glomerular Filtration Rate in Newly Diagnosed Multiple Myeloma Patients Eligible for Autologous Stem Cell Transplantation |
| title_sort | evaluation of prognostic significance of the international staging system according to glomerular filtration rate in newly diagnosed multiple myeloma patients eligible for autologous stem cell transplantation |
| topic | multiple myeloma b2-microglobulin international staging system |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tjh&un=TJH-00344 |
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